Binding molecules for treatment and detection of cancer
The present invention provides new tumor-associated antigens, binding molecules that specifically bind to the antigens, nucleic acid molecules encoding the binding molecules, compositions comprising the binding molecules and methods of identifying or producing the binding molecules. The new tumor-associated antigen are expressed on cancer cells and binding molecules capable of specifically binding to the antigens can be used in the diagnosis, prevention and/or treatment of cancer.
1. An isolated human antibody able to specifically bind to a polypeptide comprising the amino acid sequence of SEQ ID NO: 6, wherein the antibody comprises:
a heavy chain variable region comprising the amino acid sequence of SEQ ID NO: 4, and
a light chain variable region comprising the amino acid sequence of SEQ ID NO: 8.
2. An immunoconjugate comprising the antibody of claim 1 , together with a tag.
3. A composition comprising:
the antibody of claim 1 or an immunoconjugate comprising said antibody, and
a pharmaceutically acceptable carrier.