Wortmannin analogs and methods of using same in combination with chemotherapeutic agents
Novel wortmannin analogs and their use in inhibiting PI-3-kinase activity in mammals and the treatment or prevention of cancer and tumor formation in a subject are described herein. Preferably, the wortmannin analogs may be administered with other chemotherapeutic agents in the treatment of cancer.
1. A method of treating lung cancer comprising administering to a subject a pharmaceutically effective amount of a compound selected from
wherein Y is a heteroatom selected from nitrogen and sulfer and R 1 or R 2 are independently selected from an unsaturated alkyl, cyclic alkyl, or R 1 or R 2 together with Y form a heterocycle.
2. The method of claim 1 , wherein said R 1 and R 2 are a unsaturated alkyl.
3. The method of claim 1 , wherein said compound is administered orally.
4. The method of claim 1 , wherein said compound is administered intravenously.
5. The method of claim 1 , wherein said compound is:
6. The method of claim 1 , wherein said compound is:
7. The method of claim 1 , wherein the lung cancer is non small cell lung cancer.
8. The method of claim 1 , wherein R 1 and R 2 together with Y form a heterocycle.