Herbal composition
The present invention relates to a novel herbal composition comprising extract of leaves of Polyalthia longifolia and method of manufacture of said composition. The present invention relates to a herbal extract selectively comprising a compound 16-hydroxycleroda-3,13(14)-dien-15,16-olide (compound 1), as a bioactive marker and optionally other active(s). The invention also discloses methods of administration of the said herbal composition for the treatment of various inflammatory disorders. Optionally the said extract may be combined with other bioactive substances to obtain a synergistic effect.
1. A method of treating an inflammatory disorder comprising administering to a subject in need thereof a therapeutically effective amount of a composition comprising a therapeutically effective amount of an extract of leaves of the plant, Polyalthia longifolia as an active ingredient along with at least one pharmaceutically acceptable carrier, wherein said inflammatory disorder is inflammatory bowel disease, rheumatoid arthritis, juvenile rheumatoid arthritis, psoriatic arthritis, osteoarthritis, refractory rheumatoid arthritis, chronic non-rheumatoid arthritis, osteoporosis/bone resorption, coronary heart disease, atherosclerosis, vasculitis, ulcerative colitis, psoriasis, adult respiratory distress syndrome, diabetes, delayed-type hypersensitivity in skin disorders and Alzheimer's disease.
2. The method of claim 1 , wherein the composition is administered orally, topically or transdermally.
3. The method of claim 1 , wherein the inflammatory disorder is rheumatoid arthritis.
4. The method of claim 1 , wherein the extract of Polyalthia longifolia contains a bioactive marker.
5. The method of claim 4 , wherein the said bioactive marker is 16-hydroxycleroda-3,13(14)-dien-15,16-olide (compound 1).
6. The method of claim 5 , wherein 10-30% of the said compound 1 is contained in said extract of Polyalthia longifolia.