Method of wound/burn healing using copper-zinc compositions
Composition and methods for alleviating or eliminating wounds and/burns by providing an effective amount of one or more copper, zinc and copper-zinc compositions are disclosed. Treatment is accomplished through the use of topical compositions containing one or more copper or zinc salts and/or copper-zinc compounds or complexes, particularly copper-zinc malonate active ingredient.
1. A method of treating a wound or burn comprising topically applying to a wound or burn a composition comprising a copper-zinc active ingredient comprising the reaction product of a polyfunctional carboxylic acid with basic salts of copper and zinc, wherein copper, zinc and the polyfunctional carboxylic acid are in the same molecule.
2. The method as in claim 1 wherein the copper-zinc active ingredient is a water soluble copper-zinc compound.
3. The method as in claim 1 wherein the copper-zinc active ingredient comprises copper-zinc citrate, copper-zinc oxalate, copper-zinc tartarate, copper-zinc malate, copper-zinc succinate, copper-zinc malonate, copper-zinc maleate, copper-zinc aspartate, copper-zinc glutamate, copper-zinc glutarate, copper-zinc fumarate, copper-zinc glucarate, copper-zinc polyacrylic acid, copper-zinc adipate, copper-zinc pimelate, copper-zinc suberate, copper-zinc azealate, copper-zinc sebacate, copper-zinc dodecanoate, or combinations thereof.
4. The method as in claim 1 wherein the copper-zinc active ingredient is a copper-zinc malonate.
5. The method as in claim 4 wherein the copper-zinc malonate comprises about 16.5% copper and about 12.4% zinc.
6. The method of claim 1 wherein the molar ratio of copper to zinc in the copper-zinc active ingredient is from about 1:1 to about 3:1.
7. The method of claim 1 wherein the molar ratio of copper to zinc in the copper-zinc active ingredient is from about 1:1 to about 2:1.
8. The method of claim 1 wherein the copper-zinc active ingredient is present in an amount from about 0.001 to about 5% by weight of the composition.
9. The method of claim 1 wherein the copper-zinc active ingredient is present in an amount from about 0.05 to about 1% by weight of the composition.
10. The method of claim 1 wherein the copper-zinc active ingredient is present in an amount from about 0.1 to about 0.5% by weight of the composition.
11. The method according to claim 1 wherein an effective amount of copper-zinc malonate composition is applied to the skin of a user to treat skin afflicted with one or more wounds or burns.
12. The method as in claim 11 wherein the wound comprises a laceration, pressure ulcer, burn or combinations thereof.
13. The method as in claim 1 wherein the composition is a solution, emulsion, microemulsion, suspension, cream, lotion, gel, powder, solid composition, or combinations thereof.
14. The method according to claim 1 , wherein the composition comprises a dermatologically acceptable carrier or diluent.
15. A method for forming collagen, elastic fibers, elastin, or tropoelastin in the wound or burn of a patient comprising contacting a wound or burn with an effective amount of a composition wherein the composition comprises one or more copper-zinc active ingredients comprising the reaction product of a polyfunctional carboxylic acid with basic salts of copper and zinc, wherein copper, zinc and polyfunctional carboxylic acid are in the same molecule.
16. The method according to claim 15 , wherein the composition comprises a dermatologically acceptable carrier or diluent.
17. The method according to claim 15 , wherein the copper-zinc active ingredient is a water soluble copper-zinc compound.
18. The method according to claim 15 , wherein the copper-zinc active ingredient is selected from the group consisting of copper-zinc citrate, copper-zinc oxalate, copper-zinc tartarate, copper-zinc malate, copper-zinc succinate, copper-zinc malonate, copper-zinc maleate, copper-zinc aspartate, copper-zinc glutamate, copper-zinc glutarate, copper-zinc fumarate, copper-zinc glucarate, copper-zinc polyacrylic acid, copper-zinc adipate, copper-zinc pimelate, copper-zinc suberate, copper-zinc azealate, copper-zinc sebacate, copper-zinc dodecanoate, and combinations thereof.
19. The method according to claim 15 , wherein the copper-zinc active ingredient is a copper-zinc malonate.
20. The method according to claim 19 , wherein the copper-zinc malonate comprises about 16.5% copper and about 12.4% zinc.
21. The method according to claim 15 , comprising from about 0.001 to about 5 percent by weight of the copper-zinc active ingredient.
22. The method according to claim 15 , comprising from about 0.05 to about 1 percent by weight of the copper-zinc active ingredient.
23. The method according to claim 15 , comprising from about 0.1 to about 0.5% percent by weight of the copper-zinc active ingredient.
24. The method of claim 15 wherein the composition further comprises a skin lightening agent, a sunscreen agent, a skin conditioning agent, a skin protectant, an emollient, a humectant, or a mixture thereof.
25. A method of treating a wound or burn comprising topically applying to a wound or burn an effective amount of copper-zinc malonate, wherein the molar ratio of copper to zinc in the copper-zinc malonate is from about 1:1 to about 2:1.
26. The method according to claim 25 wherein the copper-zinc malonate was formed in a reaction media including about 1 mole copper from cupric carbonate, about 1 mole of zinc from zinc carbonate and about 3 moles of malonic acid.