Filtration devices and related methods thereof
View Patent ↗The present invention relates to filtration devices and related methods of use. In particular, the present invention relates to implantable filtration devices used, for example, for filtering impurities from a body fluid of a subject.
1. A method of treating renal failure in a subject, comprising:
(a) providing a device comprising (i) a housing defining at least one opening and (ii) a plurality of semi-permeable hollow fibers disposed within the housing; and
(b) positioning a tissue flap or an arteriovenous loop from the subject in the device through the opening so that the tissue flap or the arteriovenous loop forms a capillary bed within the housing that permits impurities in the blood of the subject to pass from the capillary bed and into the hollow fibers.
2. The method of claim 1 further comprising introducing into the device an exogenous growth factor for enhancing capillary bed formation within the housing.
3. The method of claim 1 , wherein least one growth factor is selected from the group consisting of platelet-derived growth factors, vascular endothelial growth factors, and fibroblast growth factors.
4. The method of claim 1 , wherein the arteriovenous loop is formed between a femoral artery and a femoral vein of the subject.
5. The method of claim 1 further comprising the step of implanting the device into the subject.
6. The method of claim 1 , wherein the impurities flow into a reservoir in communication with the hollow fibers.