IP Library › Granted Patent US 7,884,067
Granted Patent B2
US 7,884,067 · App. 10/509,170 · Granted Feb 8, 2011

Peptides derived from cadherin and methods of use thereof

Assignee: Mount Sinai School of Medicine of New York University
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Quick Facts
Patent No.
US 7,884,067
App. No.
10/509,170
Granted
Feb 8, 2011
Kind
B2
Abstract

The present invention provides polypeptides and peptides derived from cadherin. The polypeptides and peptides are useful in a method of inhibiting amyloid deposition and a method of inhibiting tumor metastasis. A method of determining susceptibility to Alzheimer's disease and a method of screening for agents that modify cadherin processing are also provided.

Claims (4)

1. A peptide that binds to presenilin-1 and comprises the sequence EGGGE (SEQ ID NO: 5) wherein the peptide is from five to fifteen amino acids in length.

2. The peptide of claim 1 comprising a sequence selected from the group consisting of EGGGEEDQDFDL (SEQ ID NO: 1), EGGGEMDTTSYD (SEQ ID NO: 2), EGGGEEDQDYDLS (SEQ ID NO: 3) and EGGGEED (SEQ ID NO: 4).

3. A composition comprising the peptide of claim 1 .

4. A method of inhibiting Presenilin-1-mediated γ-secretase activity comprising contacting a cell capable of exhibiting such activity with the composition of claim 1 .

Assignments (2)
CONFIRMATORY LICENSE Recorded Apr 8, 2014
From: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 032631/0393 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Mar 24, 2005
From: ROBAKIS, NIKOLAOS; MARAMBAUD, PHILIPPE; GEORGAKOPOULOS, ANASTASIOS
To: MOUNT SINAI SCHOOL OF MEDICINE OF NEW YORK UNIVERSITY
Reel/Frame 015957/0357 →
Continuity (2)
Provisional Application 60327617 · Oct 5, 2001
Related Publication 20050245453A1 · Nov 3, 2005