Mammalian receptor proteins DCRS5; method of treatment
Nucleic acids encoding mammalian, e.g., primate, receptors, purified receptor proteins and fragments thereof. Antibodies, both polyclonal and monoclonal, are also provided. Methods of using the compositions for both diagnostic and therapeutic utilities are described.
1. A method of treating a human subject experiencing rheumatoid arthritis comprising administering an effective amount of an antagonist antibody that specifically binds to DCRS5 (SEQ ID NO: 2), or an antigen binding fragment thereof.
2. The method of claim 1 , wherein the antibody or antigen binding fragment thereof comprises a polyclonal antibody.
3. The method of claim 1 , wherein the antibody or antigen binding fragment thereof comprises a monoclonal antibody.
4. The method of claim 1 , wherein the antibody or an antigen binding fragment thereof comprises an Fab, Fv, or F(ab′)2 antibody fragment of a monoclonal antibody.
5. The method of claim 1 , wherein the antibody or antigen binding fragment thereof comprises a humanized antibody.
6. The method of claim 1 , wherein the antibody or an antigen binding fragment thereof comprises an Fab, Fv, or F(ab′)2 antibody fragment of a humanized antibody.
7. The method of claim 1 , wherein the antibody or antigen binding fragment thereof comprises an Fab, Fv, or F(ab′)2 antibody fragment.
8. A method of treating a human subject experiencing rheumatoid arthritis comprising administering an effective amount of an antagonist antibody that specifically binds to a polypeptide comprising residues 1-606 of SEQ ID NO: 2, or an antigen binding fragment thereof.
9. The method of claim 8 , wherein the antibody or antigen binding fragment thereof comprises a polyclonal antibody.
10. The method of claim 8 , wherein the antibody or antigen binding fragment thereof comprises a monoclonal antibody.
11. The method of claim 8 , wherein the antibody or an antigen binding fragment thereof comprises a humanized antibody.
12. The method of claim 8 , wherein the antibody or antigen binding fragment thereof comprises an Fab, Fv, or F(ab′)2 antibody fragment.
13. The method of claim 8 , wherein the antibody or antigen binding fragment thereof comprises an Fab, Fv, or F(ab′)2 antibody fragment of a monoclonal antibody.
14. The method of claim 8 , wherein the antibody or antigen binding fragment thereof comprises an Fab, Fv, or F(ab′)2 antibody fragment of a humanized antibody.