Fibrinogen-based tissue adhesive containing an elastase inhibitor

1. A fibrinogen-based tissue adhesive, characterized in that it comprises a therapeutically effective amount of fibrinogen admixed with 0.001-0.0001 U/ml of elastase alpha-1 proteinase inhibitor.

2. A tissue adhesive of claim 1 , wherein said tissue adhesive is comprised of human proteins.

3. A tissue adhesive of claim 1 , wherein said tissue adhesive is comprised of human blood or plasma proteins characterized in that it is composed exclusively of human blood or plasma proteins.

4. A tissue adhesive of claim 1 , wherein ratio in weight of the elastase alpha-1 proteinase inhibitor to said fibrinogen is from 1:500 to 1:110,000.

5. A tissue adhesive of claim 1 , wherein said tissue adhesive contains at least 10 - 6 U of elastase alpha-1 proteinase inhibitor per gram of fibrinogen.

6. A tissue adhesive of claim 1 , further comprising plasminogen in an amount of at least 0.0001 mg/mg of fibrinogen.

7. A tissue adhesive of claim 1 , wherein it does not contain any plasminogen.

8. A tissue adhesive of claim 1 , wherein it further comprises a plasmin activator inhibitor which is selected from the group consisting of aprotinin, alpha-2-macroglobulin, alpha-1-antitrypsin, e-aminocaproic acid, tranexamic acid, and mixtures thereof.

9. A tissue adhesive of claim 1 , wherein it further comprises an antibiotic which is selected from the group consisting of aminoglycosides, betalactams, polypeptides, phosphomycin, tetracyclines and mixtures thereof.

10. A tissue adhesive of claim 1 , wherein it comprises Factor XIII in an amount of at least 0.001 U/mg of fibrinogen.

11. A tissue adhesive of claim 1 , wherein it is free from kininogenic proteins.

12. A tissue adhesive of claim 1 , wherein the tissue adhesive is present in combination with a solid surface as a fleece.

13. A tissue adhesive of claim 12 , wherein the solid surface is a collagen, gelatin or polysaccharide surface.

14. A tissue adhesive of claim 1 , wherein in an environment of high fibrinolytic activity it is resistant to lysis for a period of time of at least 10 hours.

15. A tissue adhesive of claim 1 , wherein it is lyophilized.

16. A tissue adhesive of claim 1 , wherein it is present in solution.

17. A tissue adhesive of claim 16 , wherein the solution is deep frozen.

18. A tissue adhesive of claim 1 , wherein it is present in virus inactivated form.

19. A tissue adhesive of claim 1 , wherein the elastase alpha-1 proteinase inhibitor is of recombinant origin.

20. A tissue adhesive system, wherein it comprises the tissue adhesive of claim 1 as one component thereof.

21. A tissue adhesive system of claim 20 , wherein it further comprises thrombin and optionally calcium.

22. A tissue adhesive system, comprising a therapeutically effective amount of fibrinogen and 0.001-0.0001 U/ml of elastase alpha-1 proteinase inhibitor.

23. A tissue adhesive system of claim 22 , wherein it further comprises an application device for the components of the system, in particular a double-syringe system.