IP Library Granted Patent US 7,893,304
Granted Patent B2
US 7,893,304 · App. 11/816,625 · Granted Feb 22, 2011

Hydroquinone long-chain derivatives and/or phenoxy long-chain derivatives, and pharmaceuticals comprising the same

Assignee: Meiji Dairies Corporation
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Quick Facts
Patent No.
US 7,893,304
App. No.
11/816,625
Granted
Feb 22, 2011
Kind
B2
Abstract

The present invention provides compounds that are useful for preventing or treating brain dysfunctions, motor dysfunctions, or urinary dysfunctions caused by the degeneration and/or loss of the central nervous system or peripheral nervous system cells.

Claims (28)

1. A compound represented by the following formula (1), or a pharmaceutically acceptable salt of formula (1):

wherein,

R 1 and R 4 are each a methyl group;

R 2 is a hydrogen atom;

R 3 and R 5 are each a hydrogen atom; and

X represents an alkylene group with 10 to 20 carbons.

2. An antioxidant comprising as an active ingredient the compound of claim 1 , including pharmaceutically acceptable salts of formula (1).

3. A nerve growth-promoting agent comprising as an active ingredient the compound of claim 1 , including pharmaceutically acceptable salts of formula (1).

4. A therapeutic agent for treating a dysfunction caused by degeneration and/or loss of the central nervous system and/or peripheral nervous system neurons, which comprises as an active ingredient the compound of claim 1 , including pharmaceutically acceptable salts of formula (1).

5. A compound represented by the following formula (2), or a pharmaceutically acceptable salt of formula (2):

wherein,

R 6 and R 9 are each an alkyl group;

R 7 is a hydrogen atom or an alkoxy group;

R 8 and R 10 are each a hydrogen atom;

A represents an oxygen atom or NH, and m is 0 or 1; and

Y represents an alkylene group with 10 to 20 carbons, and Z represents a hydroxyl group.

6. The compound of claim 5 , wherein R 6 and R 9 are each a methyl group, R 7 is a methoxy group, R 8 and R 10 are each a hydrogen atom, and m is 0.

7. The compound of claim 5 , wherein R 6 and R 9 are each a methyl group, R 7 , R 8 and R 10 are each a hydrogen atom, A is an oxygen atom, and m is 1.

8. The compound of claim 5 , wherein R 6 and R 9 are each a methyl group, R 7 , R 8 and R 10 are each a hydrogen atom, A is NH, and m is 1.

9. The compound of claim 5 , wherein Y is an alkylene group with 12 carbons.

10. The compound of claim 5 , wherein Y is an alkylene group with 18 carbons.

11. An antioxidant comprising as an active ingredient the compound of claim 5 , including pharmaceutically acceptable salts of formula (2).

12. A nerve growth-promoting agent comprising as an active ingredient the compound of claim 5 , including pharmaceutically acceptable salts of formula (2).

13. A therapeutic agent for treating a dysfunction caused by degeneration and/or loss of the central nervous system and/or peripheral nervous system neurons, which comprises as an active ingredient the compound of claim 5 , including pharmaceutically acceptable salts of formula (2).

14. A method for treating a dysfunction caused by degeneration and/or loss of the central nervous system and/or peripheral nervous system neurons, wherein the method comprises the step of administering an effective amount of the compound of claim 1 , including pharmaceutically acceptable salts of formula (1) to a patient who has a dysfunction caused by degeneration and/or loss of the central nervous system and/or peripheral nervous system neurons.

15. A method for preparing a therapeutic agent wherein said method comprises combining a compound of claim 1 , including pharmaceutically acceptable salts of formula (1), with a pharmaceutically acceptable carrier.

16. A method for treating a dysfunction caused by degeneration and/or loss of the central nervous system and/or peripheral nervous system neurons, wherein the method comprises the step of administering an effective amount of the compound of claim 5 , including pharmaceutically acceptable salts of formula (2), to a patient who has a dysfunction caused by degeneration and/or loss of the central nervous system and/or peripheral nervous system neurons.

17. A method for preparing a therapeutic agent wherein said method comprises combining a compound of claim 5 , including pharmaceutically acceptable salts of formula (2), with a pharmaceutically acceptable carrier.

Assignments (3)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Feb 11, 2013
From: MEIJI CO., LTD.
To: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS); UNIVERSITE DE STRASBOURG
Reel/Frame 029788/0932 →
CHANGE OF NAME Recorded Aug 15, 2011
From: MEIJI DAIRIES CORPORATION
To: MEIJI CO., LTD
Reel/Frame 026748/0640 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Aug 29, 2008
From: LUU, BANG; BAGNARD, DOMINIQUE; HANBALI, MAZEN; YAMADA, MASASHI; SUZUKI, HIROTO
To: MEIJI DAIRIES CORPORATION
Reel/Frame 021460/0363 →
Priority Claims (1)
JP 2005-054012 · Feb 28, 2005 · national
Continuity (1)
Related Publication 20090036542A1 · Feb 5, 2009