Cell cycle regulation and differentiation
The present invention provides compositions and methods for regulating neural cell proliferation or differentiation. The present invention also provides methods for selecting for bioactive agents effective in regulating proliferation or differentiation.
1. A method of regulating proliferation or differentiation of a neural cell comprising contacting said neural cell with a bioactive agent effective in modulating the activity or expression level of transcription factor KLF9, thereby regulating said proliferation or differentiation of said neural cell.
2. The method of claim 1 , wherein said neural cell is a glial cell.
3. The method of claim 2 , wherein said glial cell has undergone no more than four divisions.
4. The method of claim 2 , wherein said glial cell is an immature oligodendrocyte (OL) or an oligodendrocyte precursor cell (OPC).
5. The method of claim 1 , wherein said regulation reduces proliferation or promotes differentiation of said neural cell.
6. The method of claim 1 , wherein said regulation promotes proliferation or reduces differentiation of said neural cell.