Pyrazole-derivatives as factor Xa inhibitors

1. A compound of formula I,

wherein

R 0 is a monocyclic or bicyclic 6- to 14-membered aryl, wherein, the aryl is mono-, di- or trisubstituted independently of one another by R 8 , or

a monocyclic or bicyclic 4- to 15-membered heterocyclyl, containing one, two, three or four heteroatoms selected from the group consisting of nitrogen, sulfur and oxygen, wherein, said heterocyclyl is unsubstituted or mono-, di-, or trisubstituted independently of one another by R 8 , and which is additionally substituted by a monocyclic or bicyclic 4- to 15-membered heterocyclyl, containing one, two, three or four heteroatoms selected from nitrogen, sulfur and oxygen, wherein heterocyclyl is unsubstituted or mono-, di- or trisubstituted independently of one another by R 8 ,

R 8 is

1) halogen,

2) —NO 2 ,

3) —CN,

4) —C(O)—NH 2 ,

5) —OH,

6) —NH 2 ,

7) —O—CF 3

8) a monocyclic or bicyclic 6- to 14-membered aryl, wherein aryl is mono-, di- or trisubstituted independently of one another by halogen or —O—(C 1 -C 8 )-alkyl,

9) —(C 1 -C 8 )-alkyl, wherein alkyl is unsubstituted or mono-, di- or trisubstituted independently of one another by halogen, NH 2 , —OH or methoxy,

10) —O—(C 1 -C 8 )-alkyl, wherein alkyl is unsubstituted or mono-, di- or trisubstituted independently of one another by halogen, NH 2 , —OH or methoxy,

11) —SO 2 —CH 3 or

12) —SO 2 —CF 3 ,

provided that where R 0 is a monocyclic or bicyclic 6- to 14-membered aryl, then R 8 is at least one halogen, —C(O)—NH 2 or —O—(C 1 -C 8 )-alkyl;

Q is —(C 1 -C 6 )-alkylene,

R 1 is hydrogen or —(C 1 -C 4 )-alkyl, wherein alkyl is unsubstituted or substituted one to three times by R 13 ;

R 2 is a direct bond,

V is a 3- to 7-membered heterocyclic residue containing 1, 2, 3 or 4 heteroatoms selected from nitrogen, sulfur and oxygen, wherein said heterocyclic residue is unsubstituted or mono-, di- or trisubstituted independently of one another by R 14 ,

R 14 is halogen, —OH, ═O, —(C 1 -C 8 )-alkyl, —(C 1 -C 4 )-alkoxy, —NO 2 , —(C 0 -C 4 )-alkyl-C(O)—O—R 18 , —CN, —(C 0 -C 4 )-alkyl-N(R 18 )—R 21 , —(C 0 -C 4 )-alkyl-O—R 18 , —(C 0 -C 4 )-alkyl-het, —(C 0 -C 8 )-alkyl-SO 2 H, —SO 2 —(C 1 -C 4 )-alkyl, —SO 2 —N(R 18 )—R 21 , —C(O)—NH—(C 1 -C 8 )-alkyl, —C(O)—N—[(C 1 -C 8 )-alkyl] 2 , —NR 18 —C(O)—NH—(C 1 -C 8 )-alkyl, —C(O)—NH 2 , —S—R 18 , or —NR 18 —C(O)—NH—[(C 1 -C 8 )-alkyl] 2 ,

wherein R 18 and R 21 are independently selected from hydrogen atom, —(C 1 -C 3 )-perfluoroalkyl, and —(C 1 -C 6 )-alkyl;

G is a direct bond;

M is

—(C 1 -C 8 )-alkyl, wherein alkyl is unsubstituted or mono-, di- or trisubstituted independently of one another by R 14 ;

R 3 and R 4 are, independent of one another:

1) hydrogen,

2) halogen,

3) —(C 1 -C 4 )-alkyl, wherein alkyl is unsubstituted or mono-, di- or trisubstituted independently of one another by R 13 ,

4) —(C 1 -C 3 )-perfluoroalkyl,

5) phenyl, wherein phenyl is unsubstituted or mono-, di- or trisubstituted independently of one another by R 13 ,

6) —(C 0 -C 4 )-alkylene-O—R 19 , wherein R 19 is

a) hydrogen,

b) —(C 1 -C 4 )-alkyl, wherein alkyl is unsubstituted or mono-, di-, or trisubstituted independently of one another by R 13 , or

c) phenyl, wherein phenyl is unsubstituted or mono-, di- or trisubstituted independently of one another by R 13 ,

d) —CF 3 , or

e) —CHF 2 ,

7) —NO 2 ,

8) —CN,

9) —SO S —R 11 , wherein s is 1 or 2,

10) —SO t —N(R 11 )—R 12 , wherein t is 1 or 2,

11) —(C 0 -C 4 )-alkylene-C(O)—R 11 ,

12) —(C 0 -C 4 )-alkylene-C(O)—O—R 11 ,

13) —(C 0 -C 4 )-alkylene-C(O)—N(R 11 )—R 12 ,

14) —(C 0 -C 4 )-alkylene-N(R 11 )—R 12 ,

15) —NR 10 —SO 2 —R 10 ,

16) —S—R 10 ,

17) —(C 0 -C 2 )alkylene-C(O)—O—(C 2 -C 4 )-alkylene-O—C(O)—(C 1 -C 4 )-alkyl,

18) —C(O)—O—C(R 15 ,R 16 )—O—C(O)—R 17 ,

19) —(C 0 -C 2 )alkylene-C(O)—O—(C 2 -C 4 )-alkylene-O—C(O)—O—(C 1 -C 6 -alkyl,

20) —C(O)—O—C(R 15 , R 16 )—O—C(O)—O—R 17 ,

21) —(C 0 -C 4 )-alkylene-(C 6 -C 14 )-aryl, wherein aryl is mono-, di- or trisubstituted independently of one another by R 13 ,

22) —(C 0 -C 4 )-alkylene-(C 4 -C 15 )-heterocyclyl, wherein heterocyclyl is unsubstituted or mono-, di- or trisubstituted independently of one another by R 13 ,

23) —(C 0 -C 4 )-alkylene-(C 3 -C 8 )-cycloalkyl, wherein cycloalkyl is unsubstituted or mono-, di- or trisubstituted independently of one another by R 13 ,

24) —(C 0 -C 4 )-alkylene-het, wherein het is unsubstituted or mono-, di- or trisubstituted independently of one another by R 13 ,

25) —(C 0 -C 4 )-alkylene-O—CH 2 —(C 1 -C 3 )-perfluoroalkylene-CH 2 —O—(C 0 -C 4 )-alkyl, or

26) a residue selected from the group consisting of

wherein Me is methyl, or

two —OR 19 residues and adjacent atoms through which they are attached form together a 5- or 6-membered ring, that is unsubstituted or substituted one, two, three or four times by R 13 ;

R 11 and R 12 are, independently of one another:

1) hydrogen,

2) —(C 1 -C 6 )-alkyl, wherein alkyl is unsubstituted or mono-, di- or trisubstituted independently of one another by R 13 ,

3) —(C 0 -C 6 )-alkyl-(C 3 -C 8 )-cycloalkyl,

4) —SO t —R 10 , wherein t is 1 or 2,

5) —(C 0 -C 6 )-alkyl-(C 6 -C 14 )-aryl, wherein alkyl and aryl independently from one another are unsubstituted or mono-, di- or trisubstituted by R 13 ,

6) —(C 1 -C 3 )-perfluoroalkyl,

7) —O—R 17 , or

8) —(C 0 -C 6 )-alkyl-(C 4 -C 15 )-heterocyclyl, wherein alkyl and heterocyclyl independently from one another are unsubstituted or mono-, di- or trisubstituted by R 13 , or

R 11 and R 12 together with the nitrogen atom to which they are bonded can form a 4- to 8-membered monocyclic heterocyclic ring which in addition to the nitrogen atom can contain one or two identical or different ring heteroatoms selected from oxygen, sulfur and nitrogen;

wherein said heterocyclic ring is unsubstituted or mono-, di- or trisubstituted independently of one another by R 13 ;

R 13 is halogen, —NO 2 , —CN, ═O, —OH, —CF 3 , —C(O)—O—R 10 , —C(O)—N(R 10 )—R 20 , —N(R 10 )—R 20 , —(C 3 -C 8 )-cycloalkyl, —(C 0 -C 3 )-alkylene-O—R 10 , —Si—(CH 3 ) 3 , —N(R 10 )—S(O) u —R 10 , wherein u is 1 or 2, —S—R 10 , —SO r —R 10 , wherein r is 1 or 2, —S(O) V —N(R 10 ) —R 20 wherein v is 1 or 2, —C(O)—R 10 , —(C 1 -C 8 )-alkyl, —(C 1 -C 8 )-alkoxy, phenyl, phenyloxy-, —O—CF 3 , —(C 0 -C 4 )-alkyl-C(O)—O—C(R 15 , R 16 ) —C(O)—R 17 , —(C 1 -C 4 )-alkoxy-phenyl, —(C 0 -C 4 )-alkyl-C(O)—O—C(R 15 , R 16 ) —O—C(O)—O—R 17 , —(C 1 -C 3 )-perfluoroalkyl, —O—R 15 , —NH—C(O)—NH—R 10 , —NH—C(O)—O—R 10 , or a residue selected from the group consisting of

R 10 and R 20 are independently selected from hydrogen, —(C 1 -C 6 )-alkyl, —(C 0 -C 4 )-alkyl-OH, —(C 0 -C 4 )-alkyl-O—(C 1 -C 4 )-alkyl, and —(C 1 -C 3 )-perfluoroalkyl;

R 15 and R 16 are independently selected from hydrogen, —(C 1 -C 6 )-alkyl, or, together with the carbon atom to which they are bonded, can form a 3- to 6 membered carbocyclic ring unsubstituted or substituted one to three times by R 10 ; and

R 17 is —(C 1 -C 6 )-alkyl, —(C 1 -C 6 )-alkyl-OH, —(C 1 -C 6 )-alkyl-O—(C 1 -C 6 )-alkyl, —(C 3 -C 8 )-cycloalkyl, —(C 1 -C 6 )-alkyl-O—(C 1 -C 8 )-alkyl-(C 3 -C 8 )-cycloalkyl, —(C 1 -C 6 )-alkyl-(C 3 -C 8 )-cycloalkyl, wherein said cycloalkyl ring is unsubstituted or substituted one, two or three times by —OH, —O—(C 1 -C 4 )-alkyl or R 10 ;

or a stereoisomer thereof, mixture of stereoisomers thereof in any ratio, or a physiological tolerable salt thereof.

2. The compound according to claim 1 , wherein,

R 0 is:

heterocyclyl, selected from pyridyl, 2-pyridyl, 3-pyridyl, 4-pyridyl, pyrrolyl, 2-pyrrolyl, 3-pyrrolyl, furyl, 2-furyl, 3-furyl; thienyl, 2-thienyl, 3-thienyl, imidazolyl, pyrazolyl, oxazolyl, isoxazolyl, thiazolyl, thiadiazolyl, isothiazolyl, triazolyl, tetrazolyl, pyridazinyl and pyrazinyl, wherein said heterocyclyl is unsubstituted or mono-, di- or trisubstituted independently of one another by R 8 ,

and in addition is substituted by a residue selected out of the group pyridyl, 2-pyridyl, 3-pyridyl, 4-pyridyl, pyrrolyl, 2-pyrrolyl, 3-pyrrolyl, furyl, 2-furyl, 3-furyl; thienyl, 2-thienyl, 3-thienyl, imidazolyl, pyrazolyl, oxazolyl, isoxazolyl, thiazolyl, thiadiazolyl, isothiazolyl, triazolyl, tetrazolyl, pyridazinyl or pyrazinyl, that is unsubstituted or mono-, di- or trisubstituted independently of one another by R 8 ;

R 8 is selected from:

F, Cl, Br or I;

—C(O)—NH 2 ;

—(C 1 -C 4 )-alkyl, wherein alkyl is unsubstituted or mono-, di-, or trisubstituted independently of one another by halogen, —OH, or methoxy; or

—O—(C 1 -C 4 )-alkyl, wherein alkyl is unsubstituted or mono-, di-, or trisubstituted independently of one another by halogen or methoxy,

provided that R 8 is at least one halogen, —C(O)—NH 2 or —O—(C 1 -C 8 )-alkyl;

R 1 is hydrogen or —(C 1 -C 2 )-alkyl;

V is a 3- to 7-membered heterocyclic residue selected from aziridine, azirine, azetidine, azetidinone, 1,4-diazepane, pyrrole, pyrrolidine, pyridonyl, imidazole, pyrazole, 1,2,3-triazole, 1,2,4-triazole, tetrazole, pyridine, pyrimidine, pyrazine, 1,2,3-triazine, 1,2,4-triazine, 1,3,5-triazine, tetrazine, azepine, diazirine, 1,2-diazepine, 1,3-diazepine, 1,4-diazepine, pyridazine, piperidine, piperazine, pyrrolidinone, ketopiperazine, furan, pyran, dioxole, 1,4-oxazepane, 1,4-oxazepine, oxazole, isoxazole, 2-isoxazoline, isoxazolidine, morpholine, oxirane, oxaziridine, 1,3-dioxolene, 1,3-dioxolane, 1,2-oxazine, 1,3-oxazine, 1,4-oxazine, oxaziridine, thiophene, thiopyran, thietan, thiazole, isothiazole, isothiazoline, isothiazolidine, 1,2-oxathiolan, thiodiazole, thiopyran, 1,2-thiazine, 1,3-thiazole, 1,3-thiazine, 1,4-thiazine, thiadiazine or thiomorpholine,

any of which can be unsubstituted or mono-, di- or trisubstituted independently of one another by R 14 ,

R 14 is fluorine, chlorine, —OH, ═O, —(C 1 -C 8 )-alkyl, —CN, —C(O)—NH—(C 1 -C 8 )-alkyl, —C(O)—N—[(C 1 -C 8 )-alkyl] 2 , or —C(O)—NH 2 ,

M is

—(C 1 -C 6 )-alkyl, wherein alkyl is unsubstituted or mono-, di- or trisubstituted independently of one another by R 14 ,

R 3 and R 4 are, independent of one another:

1) hydrogen,

2) halogen,

3) —(C 1 -C 4 )-alkyl, wherein alkyl is unsubstituted or mono-, di- or trisubstituted independently of one another by R 13 ,

4) —(C 1 -C 3 )-perfluoroalkyl,

5) phenyl, wherein phenyl is unsubstituted or mono-, di- or trisubstituted independently of one another by R 13 ,

6) —(C 0 -C 4 )-alkylene-O—R 19 , wherein R 19 is

a) hydrogen,

b) —(C 1 -C 4 )-alkyl, wherein alkyl is unsubstituted or mono-, di- or trisubstituted independently of one another by R 13 , or

c) phenyl, wherein phenyl is unsubstituted or mono-, di- or trisubstituted independently of one another by R 13 ,

d) —CF 3 , or

e) —CHF 2 ,

8) —CN,

9) —SO s —R 11 , wherein s is 1 or 2,

10) —SO t —N(R 11 )— R 12 , wherein t is 1 or 2,

11) —(C 0 -C 4 )-alkylene-C(O)—R 11 ,

12) —(C 0 -C 4 )-alkylene-C(O)—O—R 11

13) —(C 0 -C 4 )-alkylene-C(O)—N(R 11 ) —R 12 ,

14) —(C 0 -C 4 )-alkylene-N(R 11 ) —R 12 ,

15) —NR 10 —SO 2 —R 10 ,

17) —(C 0 -C 2 )alkylene-C(O)—O—(C 2 -C 4 )-alkylene-O—C(O)—(C 1 -C 4 )-alkyl,

18) —C(O)—O—C(R 15 R 16 ) —O 17 —C(O)—O—R 17 ,

19) —(C 0 -C 2 )alkylene-C(O)—O—(C 2 -C 4 )-alkylene-O—C(O)—O—(C 1 -C 6 )-alkyl,

20) —C(O)—O—C(R 15 ,R 16 ) —O—C(O)—R 17 ,

23) —(C 0 -C 4 )-alkylene-(C 3 -C 6 )-cycloalkyl, wherein cycloalkyl is unsubstituted or mono-, di- or trisubstituted independently of one another by R 13 ,

25) —(C 0 -C 3 )-alkylene-O—CH 2 —CF 2 —CH 2 —O—(C 0 -C 3 )-alkyl, —(C 0 -C 3 )-alkylene-O—CH 2 —CF 2 —CF 2 —CH 2 —O—(C 0 -C 3 )-alkyl, or —(C 0 -C 3 )-alkylene-O—CH 2 —(C 1 -C 3 )-perfluoroalkylene-CH 2 —OH, or

26) residue selected from the group consisting of

wherein Me is methyl, or

two —OR 19 residues and adjacent atoms through which they are attached form together a 5- or 6-membered ring, that is unsubstituted or substituted one, two, three or four times by R 13 ;

R 11 and R 12 are, independently of one another:

1) hydrogen,

2) —(C 1 -C 6 )-alkyl, wherein alkyl is unsubstituted or mono-, di- or trisubstituted independently of one another by R 13 ,

5) —(C 0 -C 6 )-alkyl-(C 6 -C 14 )-aryl, wherein alkyl and aryl independently from one another are unsubstituted or mono-, di- or trisubstituted by R 13 ,

7) —O—R 17 , or

8) —(C 0 -C 6 )-alkyl-(C 4 -C 15 )-heterocyclyl, wherein alkyl and heterocyclyl independently from one another are unsubstituted or mono-, di- or trisubstituted by R 13 , or

R 11 and R 12 together with the nitrogen atom to which they are bonded form a monocyclic heterocyclic ring selected from azepine, azetidine, 1,4-diazepane, dioxazole, dioxazine, 1,2-diazepine, 1,3-diazepine, 1,4-diazepine, imidazole, imidazoline, imidazolidine, isothiazole, isothiazolidine, isothiazoline, isoxazole, isoxazoline, isoxazolidine, 2-isoxazoline, ketopiperazine, morpholine, [1,4]-oxazepane, 1,4-oxazepine, oxazole, piperazine, piperidine, pyrazine, pyrazole, pyrazoline, pyrazolidine, pyridazine, pyridine, pyrimidine, pyrrole, pyrrolidine, pyrrolidinone, pyrroline, tetrahydropyridine, tetrazine, tetrazole, thiazole, thiadiazole, thiazolidine, thiazoline, thiomorpholine, thiophene, 1,2,3-triazine, 1,2,4-triazine, 1,3,5-triazine, 1,2,3-triazole and 1,2,4-triazole, any of which can be unsubstituted or mono-, di- or trisubstituted independently of one another by R 13 ;

R 13 is fluorine, chlorine, —NO 2 , —CN, ═O, —OH, —CF 3 , —C(O)—O—R 10 , —C(O)—N(R 10 )—R 20 , —N(R 10 )—R 20 , —(C 0 -C 3 )-alkylene-O—R 10 , —Si—(CH 3 ) 3 , —N(R 10 ) —S(O) 2 —R 10 , —S—R 10 , —SO 2 —R 10 , —S(O) 2 —N(R 10 ) —R 20 , —C(O)—R 10 , —(C 1 -C 8 )-alkyl, —(C 1 -C 8 )-alkoxy, phenyl, phenyloxy-, —O—CF 3 , —(C 1 -C 3 )-perfluoroalkyl, —NH—C(O)—NH—R 10 , —(C 0 -C 4 )-alkyl-C(O)—O—C(R 15 , R 16 ) —O—C(O)—R 17 , —(C 1 -C 4 )-alkoxy-phenyl, —(C 0 -C 4 )-alkyl-C(O)—O—C(R 15 , R 16 ) —O—C(O)—O—R 17 , —O—R 15 , —NH—C(O)—O—R 10 , or residue selected from the group consisting of

wherein Me is methyl.

3. The compound according to claim 1 , wherein,

R 0 is heterocyclyl, wherein said heterocyclyl is selected from pyridyl, 2- pyridyl, 3-pyridyl, 4-pyridyl, pyrrolyl, 2-pyrrolyl, 3-pyrrolyl, furyl, 2-furyl, 3-furyl; thienyl, 2-thienyl, 3-thienyl, imidazolyl, pyrazolyl, oxazolyl, isoxazolyl, thiazolyl, thiadiazolyl, isothiazolyl, triazolyl, tetrazolyl, pyridazinyl and pyrazinyl, wherein said heterocyclyl is unsubstituted or mono-, di- or trisubstituted independently of one another by R 8 ,

and, in addition, is substituted by a residue selected from pyridyl, 2-pyridyl, 3-pyridyl, 4-pyridyl, pyrrolyl, 2-pyrrolyl, 3-pyrrolyl, furyl, 2-furyl, 3-furyl; thienyl, 2-thienyl, 3-thienyl, imidazolyl, pyrazolyl, oxazolyl, isoxazolyl, thiazolyl, thiadiazolyl, isothiazolyl, triazolyl, tetrazolyl, pyridazinyl and pyrazinyl, which can be unsubstituted or mono-, di- or trisubstituted independently of one another by R 8 ;

R 8 is selected from:

F, Cl, Br, or I;

—C(O)—NH 2 ;

—(C 1 -C 4 )-alkyl, wherein alkyl is unsubstituted or mono-, di- or trisubstituted independently of one another by halogen, —OH or methoxy; and

—O—(C 1 -C 4 )-alkyl, wherein alkyl is unsubstituted or mono-, di- or trisubstituted independently of one another by halogen or methoxy,

provided that R 8 is at least one halogen, —C(O)—NH 2 or —O—(C 1 -C 8 )-alkyl;

R 1 is hydrogen or —(C 1 -C 2 )-alkyl;

V is a 3- to 7-membered cyclic residue selected from azetidine, azepine, aziridine, azirine, 1,4-diazepane, 1,2-diazepine, 1,3-diazepine, 1,4-diazepine, diazirine, 1,3-dioxolane, dioxazole, furan, imidazole, isothiazole, isothiazolidine, isothiazoline, isoxazole, 2-isoxazoline, isoxazolidine, ketopiperazine, morpholine, 1,2-oxazine, 1,3-oxazine, 1,4-oxazine, oxazole, 1,2-oxathiolan, piperidine, pyran, pyrazine, pyrazole, pyridazine, piperazine, pyridine, pyridone, pyrimidine, pyrrole, pyrrolidine, pyrrolidinone, tetrazine, tetrazole, thiadiazine, 1,2-thiazine, 1,3-thiazine, 1,4-thiazine, 1,3-thiazole, thietan, thiomorpholine, thiophene, thiopyran, 1,2,3-triazine, 1,2,4-triazine, 1,3,5-triazine, 1,2,3-triazole and 1,2,4-triazole, any of which can be unsubstituted or mono-, di- or trisubstituted independently of one another by R 14 ;

R 14 is fluoro, chloro, or —(C 1 -C 4 )-alkyl;

M is

—(C 1 -C 6 )-alkyl, wherein alkyl is unsubstituted or mono-, di- or trisubstituted independently of one another by R 14 ,

R 3 and R 4 are, independent of one another:

1) hydrogen,

2) halogen,

3) —(C 1 -C 4 )-alkyl, wherein alkyl is unsubstituted or mono-, di- or trisubstituted independently of one another by R 13 ,

4) —(C 1 -C 3 )-perfluoroalkyl,

5) phenyl, wherein phenyl is unsubstituted or mono-, di- or trisubstituted independently of one another by R 13 ,

6) —(C 0 -C 4 )-alkylene-O—R 19 , wherein R 19 is

a) hydrogen,

b) —(C 1 -C 4 )-alkyl, wherein alkyl is unsubstituted or mono-, di- or trisubstituted independently of one another by R 13 , or

c) phenyl, wherein phenyl is unsubstituted or mono-, di- or trisubstituted independently of one another by R 13 ,

d) —CF 3 , or

e) —CHF 2 ,

8) —CN,

9) —SO s —R 11 , wherein t is 1 or 2,

10) —SO t —N(R 11 )—R 12 , wherein t is 1 or 2,

12) —(C 0 -C 4 )-alkylene-C(O)—O—R 11 ,

13) —(C 0 -C 4 )-alkylene-C(O)—N(R 11 )— R 12 ,

14) —(C 0 -C 4 )-alkylene-N(R 1 )— R 12 ,

15) —NR 10 —SO 2 —R 10 ,

17) —(C 0 -C 2 )alkylene-C(O)—O—(C 2 -C 4 )-alkylene-O—C(O)—(C 1 -C 4 )-alkyl,

18) —C(O)—O—C(R 15 ,R 16 )—O—C(O)—R 17

19) —(C 0 -C 2 )alkylene-C(O)—O—(C 2 -C 4 )-alkylene-O—C(O)—O—(C 1 -C 6 )-alkyl,

20) —C(O)—O—C(R 15 R 16 )—O 17 —C(O)—O—R 17 ,

23) —(C 0 -C 3 )-alkylene-(C 3 -C 6 )-cycloalkyl, or —(C 0 -C 4 )-alkylene-(C 3 -C 6 )-cycloalkyl, wherein cycloalkyl is unsubstituted or mono-, di- or trisubstituted independently of one another by R 13 ,

25) —(C 0 -C 3 )-alkylene-O—CH 2 —CF 2 —CH 2 —O—(C 0 -C 3 )-alkyl, —(C 0 -C 3 )-alkylene-O—CH 2 —CF 2 —CF 2 —CH 2 —O—(C 0 -C 3 )-alkyl, or —(C 0 -C 3 )-alkylene-O—CH 2 —(C 1 -C 3 )-perfluoroalkylene-CH 2 —OH, or

26) residue selected from the group consisting of

wherein Me is methyl;

R 11 and R 12 are, independently of one another:

1) hydrogen,

2) —(C 1 -C 4 )-alkyl, wherein alkyl is unsubstituted or mono-, di- or trisubstituted independently of one another by R 13 ,

3) —(C 0 -C 6 )-alkyl-(C 3 -C 6 )-cycloalkyl,

7) —O—R 17 , or

8) —(C 0 -C 6 )-alkyl-(C 4 -C 15 )-heterocyclyl, wherein alkyl and heterocyclyl independently from one another are unsubstituted or mono-, di- or trisubstituted by R 13 and wherein heterocyclyl is selected from azetidine, cyclopropyl, cyclobutyl, 4,5-dihydrooxazole, imidazolidine, morpholine, (1,4)-oxazepane, oxazolidine, piperidine, piperazine, pyrrolidine, tetrahydrothiophene, thiazolidine, and thiomorpholine, or

R 11 and R 12 together with the nitrogen atom to which they are bonded form a monocyclic heterocyclic ring selected from azetidine, cyclopropyl, cyclobutyl, 4,5-dihydrooxazole, imidazolidine, morpholine, (1,4)-oxazepane, 1,4-oxazepine, oxazolidine, piperidine, piperazine, pyrrolidine, tetrahydrothiophene, thiazolidine and thiomorpholine;

R 13 is fluorine, —CN, ═O, —OH, —CF 3 , —C(O)—O—R 10 , —C(O)—N(R 10 )—R 20 , —N(R 10 )—R 20 , —(C 3 -C 6 )-cycloalkyl, —(C 0 -C 3 )-alkylene-O—R 10 , —Si—(CH 3 ) 3 , —S—R 10 , —SO 2 —R 10 , —(C 1 -C 3 )-perfluoroalkyl, or residue selected from the group consisting of

wherein Me is methyl;

R 10 and R 20 are independently selected from hydrogen, —(C 1 -C 4 )-alkyl and —(C 1 -C 3 )-perfluoroalkyl;

R 15 and R 16 are independently selected from hydrogen and —(C 1 -C 4 )-alkyl, or, together with the carbon atom to which they are bonded, form a cyclopropyl, cyclobutyl, cyclopentyl or cyclohexyl ring, which can be unsubstituted or substituted one to three times by R 10 .

4. The compound according to claim 1 , wherein

R 0 is heterocyclyl selected from the group consisting of thienyl, thiadiazolyl, isoxazolyl and thiazolyl, wherein said heterocyclyl is substituted by a residue selected from the group consisting of thienyl, 2-thienyl and 3-thienyl, wherein said residue is unsubstituted or mono- or disubstituted independently of one another by R 8 ,

R 8 is F, Cl, Br, —OCH 3 , —C(O)—NH 2 or —O—CF 3 ,

R 1 is hydrogen,

V is a 3- to 7-membered cyclic residue selected from azetidine, 1,4-diazepane, isoxazole, piperazine, piperidine, pyrazine, pyridazine, pyrimidine, pyrrolidine or tetrahydropyran, any of which can be unsubstituted or mono-, di- or trisubstituted independently of one another by R 14 ,

R 14 is fluorine, chlorine, methyl, or ethyl,

M is (C 2 -C 4 )-alkyl, wherein alkyl is unsubstituted or mono- or disubstituted independently of one another by R 14 ,

R 3 and R 4 are, independent of one another:

1) hydrogen,

2) fluorine or chlorine,

3) —(C 1 -C 4 )-alkyl, wherein alkyl is unsubstituted or mono-, di- or trisubstituted independently of one another by R 13 ,

4) —(C 1 -C 3 )-perfluoroalkyl,

5) phenyl that is unsubstituted or mono-, di- or trisubstituted independently of one another by R 13 ,

6) —(C 0 -C 2 )-alkylene-O—R 19 , wherein R 19 is

a) hydrogen,

b)-(C 1 -C 4 )-alkyl, wherein alkyl is unsubstituted or mono-, di- or trisubstituted independently of one another by R 13 , or

c) phenyl, wherein phenyl is unsubstituted or mono-, di- or trisubstituted independently of one another by R 13 ,

d) —CF 3 , or

e) —CHF 2 ,

8) —CN,

9) —SO s —R 11 , wherein s is 1 or 2,

10) —SO t —N(R 11 ) —R 12 , wherein t is 1 or 2,

11) —(C 0 -C 4 )-alkylene-C(O)—R 11 ,

12) —(C 0 -C 4 )-alkylene-C(O)—O—R 11 ,

13) —(C 0 -C 4 )-alkylene-C(O)—N(R 11 )—R 12 ,

14) —(C 0 -C 4 )-alkylene-N(R 11 )—R 12 ,

15) —NR 10 —SO 2 —R 10 ,

16) —(C 0 -C 2 )alkylene-C(O)—O—(C 2 -C 4 )-alkylene-O—C(O)—(C 1 -C 4 )-alkyl,

18) —C(O)—O—C(R 15 ,R 16 ) —O—C(O)—R 17 ,

19) —(C 0 -C 2 )alkylene-C(O)—O—(C 2 -C 4 )-alkylene-O—C(O)—O—(C 1 -C 6 )-alkyl,

20) —C(O)—O—C(R 15 ,R 16 )—O—C(O)—O—R 17 ,

23) —(C 0 -C 4 )-alkylene-(C 3 -C 8 )-cycloalkyl selected from the group consisting of —(C 0 -C 3 )-alkylene-(C 3 -C 6 )-cycloalkyl and —(C 0 -C 4 )-alkylene-(C 3 -C 6 )-cycloalkyl, wherein cycloalkyl is unsubstituted or mono-, di- or trisubstituted independently of one another by R 13 ,

24) —(C 0 -C 4 )-alkylene-het selected from the group consisting of pyridinyl and thiazolyl, any of which can be unsubstituted or mono-, di- or trisubstituted independently of one another by R 13 ,

25) —(C 0 -C 3 )-alkylene-O—CH 2 —CF 2 —CH 2 —O—(C 0 -C 3 )-alkyl, —(C 0 -C 3 )-alkylene-O—CH 2 —CF 2 —CF 2 —CH 2 —O—(C 0 -C 3 )-alkyl, or —(C 0 -C 3 )-alkylene-O—CH 2 —(C 1 -C 3 )-perfluoroalkylene-CH 2 —OH, or

26) residue selected from the group consisting of the following

wherein Me is methyl,

R 11 and R 12 are independently of one another:

1) hydrogen,

2) —(C 1 -C 4 )-alkyl, wherein alkyl is unsubstituted or mono-, di- or trisubstituted independently of one another by R 13 ,

3)-(C 0 -C 6 )-alkyl-(C 3 -C 6 )-cycloalkyl,

7) —O—R 17 , or

8) —(C 0 -C 6 )-alkyl-heterocyclyl, wherein alkyl and heterocyclyl independently from one another are unsubstituted or mono-, di- or trisubstituted by R 13 and wherein heterocyclyl is selected out of the group azetidine, imidazolidine, morpholine, 1,4-oxazepane or pyrrolidine or

R 11 and R 12 together with the nitrogen atom to which they are bonded can form a monocyclic heterocyclic ring selected from the group consisting of azetidine, imidazolidine, morpholine, 1,4-oxazepane, 1,4-oxazepine, piperazine, piperidine, pyrrolidine and thiomorpholine,

R 13 is selected from fluorine, chlorine, —CN, ═O, —OH, —CF 3 , —C(O)—O—R 10 , —C(O)—N(R 10 ) —R 20 , —N(R 10 )—R 20 , —(C 3 -C 6 )-cycloalkyl, —(C 0 -C 3 )-alkylene-O—R 10 , —Si—(CH 3 ) 3 , —S—R 10 , —SO 2 —R 10 , —(C 1 -C 4 )-alkyl, —(C 1 -C 3 )-perfluoroalkyl, and residues selected from the group consisting of the following

wherein Me is methyl,

R 10 and R 20 are independently selected from hydrogen, —(C 1 -C 4 )-alkyl and —(C 1 -C 3 )-perfluoroalkyl,

R 15 and R 16 are independently selected from hydrogen and —(C 1 -C 4 )-alkyl, or together with the carbon atom to which they are bonded form a 3- to 6- membered carbocyclic ring selected from the group consisting of cyclopropyl, cyclobutyl, cyclopentyl and cyclohexyl, wherein each ring is unsubstituted or substituted one to three times by R 10 , and

R 17 is —(C1-C6)-alkyl, —(C1-C6)-alkyl-OH, —(C1-C6)-alkyl-O—(C1-C6)-alkyl, —(C3-C8)-cycloalkyl, —(C1-C6)-alkyl-O—(C1-C8)-alkyl-(C3-C8)-cycloalkyl, —(C1-C6)-alkyl-(C3-C8)-cycloalkyl, wherein said cycloalkyl ring is unsubstituted or substituted one, two or three times by —OH, —O—(C1-C4)-alkyl or R 10 .

5. The compound according to claim 1 , having the formula Ib,

or a stereoisomer thereof, mixture of stereoisomers thereof in any ratio, or a physiological tolerable salt thereof.

6. The compound according to claim 1 , having the formula Ic,

or a stereoisomer thereof, mixture of stereoisomers thereof in any ratio, or a physiological tolerable salt thereof.

7. The compound according to claim 1 selected from the group consisting of

2-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-5-thiophen-2-yl-2H-pyrazole-3-carboxylic acid (1-isopropyl-piperidin-4-yl)-amide,

1-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-5-thiophen-2-yl-1H-pyrazole-3-carboxylic acid (1-isopropyl-piperidin-4-yl)-amide,

2-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-5-methyl-2H-pyrazole-3-carboxylic acid (1-isopropyl-piperidin-4-yl)-amide,

1-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-5-methyl-1H-pyrazole-3-carboxylic acid (1-isopropyl-piperidin-4-yl)-amide,

2-(6-Chloro-benzothiazol-2-yl)-5-methyl-2H-pyrazole-3-carboxylic acid (1-isopropyl-piperidin-4-yl)-amide,

5-(5-Chloro-thiophen-2-yl)-2-[5-(5-chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-2H-pyrazole-3-carboxylic acid (1-isopropyl-piperidin-4-yl)-amide,

5-(5-Chloro-thiophen-2-yl)-1-[5-(5-chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-1H-pyrazole-3-carboxylic acid (1-isopropyl-piperidin-4-yl)-amide,

2-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-4-(2,4-dichloro-phenyl)-2H-pyrazole-3-carboxylic acid (1-isopropyl-piperidin-4-yl)-amide,

1-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-4-(2,4-dichloro-phenyl)-1H-pyrazole-3-carboxylic acid (1-isopropyl-piperidin-4-yl)-amide,

2-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-5-propyl-2H-pyrazole-3-carboxylic acid (1-isopropyl-piperidin-4-yl)-amide,

1-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-5-propyl-1H-pyrazole-3-carboxylic acid (1-isopropyl-piperidin-4-yl)-amide,

5-tert-Butyl-2-[5-(5-chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-2H-pyrazole-3-carboxylic acid (1-isopropyl-piperidin-4-yl)-amide,

5-tert-Butyl-1-[5-(5-chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-1H-pyrazole-3-carboxylic acid (1-isopropyl-piperidin-4-yl)-amide,

2-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-4-cyano-5-propyl-2H-pyrazole-3-carboxylic acid (1-isopropyl-piperidin-4-yl)-amide,

1-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-4-cyano-5-propyl-1H-pyrazole-3-carboxylic acid (1-isopropyl-piperidin-4-yl)-amide,

2-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-4-cyano-5-thiophen-2-yl-2H-pyrazole-3-carboxylicacid (1-isopropyl-piperidin-4-yl)-amide,

1-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-4-cyano-5-thiophen-2-yl-1H-pyrazole-3-carboxylic acid (1-isopropyl-piperidin-4-yl)-amide,

2-[2-(5-Chloro-thiophen-2-yl)-thiazol-4-ylmethyl]-5-thiophen-2-yl-2H-pyrazole-3-carboxylic acid (1-isopropyl-piperidin-4-yl)-amide,

1-[2-(5-Chloro-thiophen-2-yl)-thiazol-4-ylmethyl]-5-thiophen-2-yl-1H-pyrazole-3-carboxylic acid (1-isopropyl-piperidin-4-yl)-amide,

2-(6-Chloro-benzo[b]thiophen-2-ylmethyl)-5-thiophen-2-yl-2H-pyrazole-3-carboxylic acid (1-isopropyl-piperidin-4-yl)-amide,

1-(6-Chloro-benzo[b]thiophen-2-ylmethyl)-5-thiophen-2-yl-1H-pyrazole-3-carboxylic acid (1-isopropyl-piperidin-4-yl)-amide,

2-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-5-thiophen-2-yl-2H-pyrazole-3-carboxylic acid (3,4,5,6-tetrahydro-2H-[1,4′]bipyridinyl-4-ylmethyl)-amide,

1-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-5-thiophen-2-yl-1H-pyrazole-3-carboxylic acid (3,4,5,6-tetrahydro-2H-[1,4′]bipyridinyl-4-ylmethyl)-amide,

2-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-5-thiophen-2-yl-2H-pyrazole-3-carboxylic acid (1-isopropyl-piperidin-4-ylmethyl)-amide,

1-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-5-thiophen-2-yl-1H-pyrazole-3-carboxylic acid (1-isopropyl-piperidin-4-ylmethyl)-amide,

2-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-5-thiophen-2-yl-2H-pyrazole-3-carboxylic acid (3,4,5,6-tetrahydro-2H-[1,4′]bipyridinyl-4-yl)-amide,

1-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-5-thiophen-2-yl-1H-pyrazole-3-carboxylic acid (3,4,5,6-tetrahydro-2H-[1,4′]bipyridinyl-4-yl)-amide,

2-(4-Chloro-benzyl)-4-cyano-5-thiophen-2-yl-2H-pyrazole-3-carboxylic acid (1-isopropyl-piperidin-4-yl) -amide,

1-(4-Chloro-benzyl)-4-cyano-5-thiophen-2-yl-1H-pyrazole-3-carboxylic acid (1-isopropyl-piperidin-4-yl) -amide,

1-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-5-(1-isopropyl-piperidin-4-ylcarbamoyl)-1H-pyrazole-3-carboxylic acid methyl ester,

2-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-5-(1-isopropyl-piperidin-4-ylcarbamoyl)-2H-pyrazole-3-carboxylic acid methyl ester,

1-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-5-(1-isopropyl-piperidin-4-ylcarbamoyl)-1H-pyrazole-3-carboxylic acid,

2-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-5-(1-isopropyl-piperidin-4-ylcarbamoyl)-2H-pyrazole-3-carboxylic acid,

1-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-5-(1-isopropyl-piperidin-4-ylcarbamoyl)-1H-pyrazole-3-carboxylic acid ethyl ester,

2-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-5-(1-isopropyl-piperidin-4-ylcarbamoyl)-2H-pyrazole-3-carboxylic acid ethyl ester,

2-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-5-(morpholine-4-carbonyl)-2H-pyrazole-3-carboxylic acid (1-isopropyl-piperidin-4-yl)-amide,

1-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-5-(morpholine-4-carbonyl)-1H-pyrazole-3-carboxylic acid (1-isopropyl-piperidin-4-yl)-amide,

1-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-1H-pyrazole-3,5-dicarboxylic acid 3-dimethylamide 5-[(1-isopropyl-piperidin-4-yl)-amide], 1-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-1H-pyrazole-3,5-dicarboxylic acid 5-dimethylamide 3-[(1-isopropyl-piperidin-4-yl)-amide], 1-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-1H-pyrazole-3,5-dicarboxylic acid 3-[(2-hydroxy-ethyl)-amide]5-[(1-isopropyl-piperidin-4-yl)-amide],

1-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-1H-pyrazole-3,5-dicarboxylic acid 5-[(2-hydroxy-ethyl)-amide]3-[(1-isopropyl-piperidin-4-yl)-amide],

{[1-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-5-(1-isopropyl-piperidin-4-ylcarbamoyl)-1H-pyrazole-3-carbonyl]-amino}-acetic acid,

{[2-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-5-(1-isopropyl-piperidin-4-ylcarbamoyl)-2H-pyrazole-3-carbonyl]-amino}-acetic acid,

2-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-5-(5-oxo-4,5-dihydro-[1,3,4]oxadiazol-2-yl)-2H-pyrazole-3-carboxylic acid (1-isopropyl-piperidin-4-yl)-amide,

1-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-5-(5-oxo-4,5-dihydro-[1,3,4]oxadiazol-2-yl)-1H-pyrazole-3-carboxylic acid (1-isopropyl-piperidin-4-yl)-amide,

Sulfuric acid mono-(2-{[1-[5-(5-chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-5-(1-isopropyl-piperidin-4-ylcarbamoyl)-1H-pyrazole-3-carbonyl]-amino}-ethyl) ester,

Sulfuric acid mono-(2-{[2-[5-(5-chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-5-(1-isopropyl-piperidin-4-ylcarbamoyl)-2H-pyrazole-3-carbonyl]-amino}-ethyl) ester,

2-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-5-[4-(2-hydroxy-ethyl)-piperazine-1-carbonyl]-2H-pyrazole-3-carboxylic acid (1-isopropyl-piperidin-4-yl)-amide,

1-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-5-[4-(2-hydroxy-ethyl)-piperazine-1-carbonyl]-1H-pyrazole-3-carboxylic acid (1-isopropyl-piperidin-4-yl)-amide,

2-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-5-(2-oxo-oxazolidine-3-carbonyl)-2H -pyrazole-3-carboxylic acid (1-isopropyl-piperidin-4-yl)-amide,

1-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-5-(2-oxo-oxazolidine-3-carbonyl)-1H -pyrazole-3-carboxylic acid (1-isopropyl-piperidin-4-yl)-amide,

1-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-1H-pyrazole-3,5-dicarboxylic acid 5-[(1-isopropyl-piperidin-4-yl)-amide]3-[(2-morpholin-4-yl-ethyl)-amide],

1-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-1H-pyrazole-3,5-dicarboxylic acid 3-[(1-isopropyl-piperidin-4-yl)-amide]5-[(2-morpholin-4-yl-ethyl)-amide],

1-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-1H-pyrazole-3,5-dicarboxylic acid 3-[bis-(2-methoxy-ethyl)-amide]5-[(1-isopropyl-piperidin-4-yl)-amide],

1-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-1H-pyrazole-3,5-dicarboxylic acid 5-[bis-(2-methoxy-ethyl)-amide]3-[(1-isopropyl-piperidin-4-yl)-amide],

1-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-1H-pyrazole-3,5-dicarboxylic acid 3-[(4,5-dihydro-oxazol-2-yl)-amide]5-[(1-isopropyl-piperidin-4-yl)-amide],

1-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-1H-pyrazole-3,5-dicarboxylic acid 5-[(4,5-dihydro-oxazol-2-yl)-amide]3-[(1-isopropyl-piperidin-4-yl)-amide],

2-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-5-[3-(2-hydroxy-ethyl)-2-oxo-imidazolidine-1-carbonyl]-2H-pyrazole-3-carboxylic acid (1-isopropyl-piperidin-4-yl)-amide,

1-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-5-[3-(2-hydroxy-ethyl)-2-oxo-imidazolidine-1-carbonyl]-1H-pyrazole-3-carboxylic acid (1-isopropyl-piperidin-4-yl)-amide,

2-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-5-(2-methoxymethyl-pyrrolidine-1-carbonyl) -2H-pyrazole-3-carboxylic acid (1-isopropyl-piperidin-4-yl)-amide,

1-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-5-(2-methoxymethyl-pyrrolidine-1-carbonyl) -1H-pyrazole-3-carboxylic acid (1-isopropyl-piperidin-4-yl)-amide,

{[1-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-5-(1-isopropyl-piperidin-4-ylcarbamoyl)-1H-pyrazole-3-carbonyl]-methyl-amino}-acetic acid,

{[2-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-5-(1-isopropyl-piperidin-4-ylcarbamoyl)-2H-pyrazole-3-carbonyl]-methyl-amino}-acetic acid,

1-[1-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-5-(1-isopropyl-piperidin-4-ylcarbamoyl)-1H-pyrazole-3-carbonyl]-piperidine-4-carboxylic acid ethyl ester,

1-[2-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-5-(1-isopropyl-piperidin-4-ylcarbamoyl)-2H-pyrazole-3-carbonyl]-piperidine-4-carboxylic acid ethyl ester,

1-[1-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-5-(1-isopropyl-piperidin-4-ylcarbamoyl)-1H-pyrazole-3-carbonyl]-azetidine-2-carboxylic acid,

1-[2-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-5-(1-isopropyl-piperidin-4-ylcarbamoyl)-2H-pyrazole-3-carbonyl]-azetidine-2-carboxylic acid,

2-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-5-(thiomorpholine-4-carbonyl)-2H-pyrazole-3-carboxylic acid (1-isopropyl-piperidin-4-yl)-amide,

1-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-5-(thiomorpholine-4-carbonyl)-1H-pyrazole-3-carboxylic acid (1-isopropyl-piperidin-4-yl)-amide,

1-[1-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-5-(1-isopropyl-piperidin-4-ylcarbamoyl)-1H-pyrazole-3-carbonyl]-pyrrolidine-2-carboxylic acid,

1-[2-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-5-(1-isopropyl-piperidin-4-ylcarbamoyl)-2H-pyrazole-3-carbonyl]-pyrrolidine-2-carboxylic acid,

2-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-5-(4-hydroxy-piperidine-1-carbonyl)-2H-pyrazole-3-carboxylic acid (1-isopropyl-piperidin-4-yl)-amide,

1-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-5-(4-hydroxy-piperidine-1-carbonyl)-1H-pyrazole-3-carboxylic acid (1-isopropyl-piperidin-4-yl)-amide,

2-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-5-(2-hydroxymethyl-pyrrolidine-1-carbonyl)-2H-pyrazole-3-carboxylic acid (1-isopropyl-piperidin-4-yl)-amide,

1-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-5-(2-hydroxymethyl-pyrrolidine-1-carbonyl)-1H-pyrazole-3-carboxylic acid (1-isopropyl-piperidin-4-yl)-amide,

2-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-5-(3-hydroxy-pyrrolidine-1-carbonyl)-2H-pyrazole-3-carboxylic acid (1-isopropyl-piperidin-4-yl)-amide,

1-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-5-(3-hydroxy-pyrrolidine-1-carbonyl)-1H-pyrazole-3-carboxylic acid (1-isopropyl-piperidin-4-yl)-amide,

5-(2,5-Bis-methoxymethyl-pyrrolidine-1-carbonyl)-2-[5-(5-chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-2H-pyrazole-3-carboxylic acid (1-isopropyl-piperidin-4-yl)-amide,

5-(2,5-Bis-methoxymethyl-pyrrolidine-1-carbonyl)-1-[5-(5-chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-1H-pyrazole-3-carboxylic acid (1-isopropyl-piperidin-4-yl)-amide,

2-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-5-(4-hydroxymethyl-piperidine-1-carbonyl)-2H-pyrazole-3-carboxylic acid (1-isopropyl-piperidin-4-yl)-amide,

1-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-5-(4-hydroxymethyl-piperidine-1-carbonyl)-1H-pyrazole-3-carboxylic acid (1-isopropyl-piperidin-4-yl)-amide,

5-(8-Aza-spiro[4.5]decane-8-carbonyl)-2-[5-(5-chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-2H-pyrazole-3-carboxylic acid (1-isopropyl-piperidin-4-yl)-amide,

5-(8-Aza-spiro[4.5]decane-8-carbonyl)-1-[5-(5-chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-1H-pyrazole-3-carboxylic acid (1-isopropyl-piperidin-4-yl)-amide,

2-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-5-(3-methanesulfonyl-pyrrolidine-1-carbonyl)-2H-pyrazole-3-carboxylic acid (1-isopropyl-piperidin-4-yl)-amide,

1-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-5-(3-methanesulfonyl-pyrrolidine-1-carbonyl)-1H-pyrazole-3-carboxylic acid (1-isopropyl-piperidin-4-yl)-amide,

1-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-1H-pyrazole-3,5-dicarboxylic acid 3-[(1,1-dioxo-tetrahydro-1-thiophen-3-yl)-methyl-amide]5-[(1-isopropyl-piperidin-4-yl)-amide],

1-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-1H-pyrazole-3,5-dicarboxylic acid 5-[(1,1-dioxo-tetrahydro-1-thiophen-3-yl)-methyl-amide]3-[(1-isopropyl-piperidin-4-yl)-amide],

1-[1-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-5-(1-isopropyl-piperidin-4-ylcarbamoyl)-1H-pyrazole-3-carbonyl]-azetidine-3-carboxylic acid,

1-[2-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-5-(1-isopropyl-piperidin-4-ylcarbamoyl)-2H-pyrazole-3-carbonyl]-azetidine-3-carboxylic acid,

5-(Azetidine-1-carbonyl)-2-[5-(5-chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-2H-pyrazole-3-carboxylic acid (1-isopropyl-piperidin-4-yl)-amide,

5-(Azetidine-1-carbonyl)-1-[5-(5-chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-1H-pyrazole-3-carboxylic acid (1-isopropyl-piperidin-4-yl)-amide,

2-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-5-(3-oxo-piperazine-1-carbonyl)-2H-pyrazole-3-carboxylic acid (1-isopropyl-piperidin-4-yl)-amide,

1-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-5-(3-oxo-piperazine-1-carbonyl)-1H-pyrazole-3-carboxylic acid (1-isopropyl-piperidin-4-yl)-amide,

2-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-5-(4,4-difluoro-piperidine-1-carbonyl)-2H-pyrazole-3-carboxylic acid (1-isopropyl-piperidin-4-yl)-amide,

1-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-5-(4,4-difluoro-piperidine-1-carbonyl)-1H-pyrazole-3-carboxylic acid (1-isopropyl-piperidin-4-yl)-amide,

2-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-5-([1,4]oxazepane-4-carbonyl)-2H-pyrazole-3-carboxylic acid (1-isopropyl-piperidin-4-yl)-amide,

1-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-5-([1,4]oxazepane-4-carbonyl)-1H-pyrazole-3-carboxylic acid (1-isopropyl-piperidin-4-yl)-amide,

2-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-5-(3-hydroxy-azetidine-1-carbonyl)-2H-pyrazole-3-carboxylic acid (1-isopropyl-piperidin-4-yl)-amide,

1-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-5-(3-hydroxy-azetidine-1-carbonyl)-1H-pyrazole-3-carboxylic acid (1-isopropyl-piperidin-4-yl)-amide,

2-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-5-(2-trifluoromethyl-pyrrolidine-1-carbonyl) -2H-pyrazole-3-carboxylic acid (1-isopropyl-piperidin-4-yl)-amide,

1-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-5-(2-trifluoromethyl-pyrrolidine-1-carbonyl) -1H-pyrazole-3-carboxylic acid (1-isopropyl-piperidin-4-yl)-amide,

2-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-5-(2,2-dimethyl-pyrrolidine-1-carbonyl)-2H-pyrazole-3-carboxylic acid (1-isopropyl-piperidin-4-yl)-amide,

1-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-5-(2,2-dimethyl-pyrrolidine-1-carbonyl)-1H-pyrazole-3-carboxylic acid (1-isopropyl-piperidin-4-yl)-amide,

1-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-1H-pyrazole-3,5-dicarboxylic acid 5-[(1-isopropyl-piperidin-4-yl)-amide]3-[(2-sulfamoyl-ethyl)-amide],

1-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-1H-pyrazole-3,5-dicarboxylic acid 3-[(1-isopropyl-piperidin-4-yl)-amide]5-[(2-sulfamoyl-ethyl)-amide],

1-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-1H-pyrazole-3,5-dicarboxylic acid 3-cyclopropylamide 5-[(1-isopropyl-piperidin-4-yl)-amide],

1-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-1H-pyrazole-3,5-dicarboxylic acid 5-cyclopropylamide 3-[(1-isopropyl-piperidin-4-yl)-amide],

{[1-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-5-(1-isopropyl-piperidin-4-ylcarbamoyl)-1H-pyrazole-3-carbonyl]-amino}-methanesulfonic acid,

{[2-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-5-(1-isopropyl-piperidin-4-ylcarbamoyl)-2H-pyrazole-3-carbonyl]-amino}-methanesulfonic acid,

1-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-1H-pyrazole-3,5-dicarboxylic acid 3-cyclobutylamide 5-[(1-isopropyl-piperidin-4-yl)-amide],

1-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-1H-pyrazole-3,5-dicarboxylic acid 5-cyclobutylamide 3-[(1-isopropyl-piperidin-4-yl)-amide],

1-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-1H-pyrazole-3,5-dicarboxylic acid 5-[(1-isopropyl-piperidin-4-yl)-amide]3-[(2-methoxy-ethyl)-amide],

1-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-1H-pyrazole-3,5-dicarboxylic acid

3-[(1-isopropyl-piperidin-4-yl)-amide]5-[(2-methoxy-ethyl)-amide],

2-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-5-(pyrrolidine-1-carbonyl)-2H-pyrazole-3-carboxylic acid (1-isopropyl-piperidin-4-yl)-amide,

1-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-5-(pyrrolidine-1-carbonyl)-1H-pyrazole-3-carboxylic acid (1-isopropyl-piperidin-4-yl)-amide,

2-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-5-(cyanamide-1-carbonyl)-2H-pyrazole-3-carboxylic acid (1-isopropyl-piperidin-4-yl)-amide,

1-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-5-(cyanamide-1-carbonyl)-1H-pyrazole-3-carboxylic acid (1-isopropyl-piperidin-4-yl)-amide,

Phosphoric acid mono-(2-{[1-[5-(5-chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-5-(1-isopropyl-piperidin-4-ylcarbamoyl)-1H-pyrazole-3-carbonyl]-amino}-ethyl) ester,

Phosphoric acid mono-(2-{[2-[5-(5-chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-5-(1-isopropyl-piperidin-4-ylcarbamoyl)-2H-pyrazole-3-carbonyl]-amino}-ethyl) ester,

1-[(5-Chloro-pyridin-2-ylcarbamoyl)-methyl]-5-(1-isopropyl-piperidin-4-ylcarbamoyl)-1H-pyrazole-3-carboxylic acid methyl ester,

1-[(5-Chloro-pyridin-2-ylcarbamoyl)-methyl]-5-(1-isopropyl-piperidin-4-ylcarbamoyl)-1H-pyrazole-3-carboxylic acid,

1-[(5-Chloro-pyridin-2-ylcarbamoyl)-methyl]-1H-pyrazole-3,5-dicarboxylic acid 3-cyclobutylamide 5-[(1-isopropyl-piperidin-4-yl)-amide],

1-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-3-trifluoromethyl-1H-pyrazole-4-carboxylic acid (1-isopropyl-piperidin-4-yl)-amide,

1-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-1H-pyrazole-3,5-dicarboxylic acid bis-[(1-isopropyl-piperidin-4-yl)-amide],

2-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-4-cyano-2H-pyrazole-3-carboxylic acid (1-isopropyl-piperidin-4-yl)-amide,

1-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-4-cyano-1H-pyrazole-3-carboxylic acid (1-isopropyl-piperidin-4-yl)-amide,

2-[(4-Chloro-phenylcarbamoyl)-methyl]-4-cyano-2H-pyrazole-3-carboxylic acid (1-isopropyl-piperidin-4-yl)-amide,

3-{[1-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-5-(1-isopropyl-piperidin-4-ylcarbamoyl)-1H-pyrazole-3-carbonyl]-amino}-propionic acid,

1-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-1H-pyrazole-3,5-dicarboxylic acid 5-[(1-isopropyl-piperidin-4-yl)-amide]3-(methoxy-amide),

1-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-1H-pyrazole-3,5-dicarboxylic acid 3-carbamoylmethyl-amide 5-[(1-isopropyl-piperidin-4-yl)-amide],

{[1-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-5-(1-isopropyl-piperidin-4-ylcarbamoyl)-1H-pyrazole-3-carbonyl]-amino}-acetic acid ethyl ester,

1-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-1H-pyrazole-3,5-dicarboxylic acid 3-[(3-hydroxy-propyl)-amide]5-[(1-isopropyl-piperidin-4-yl)-amide],

1-[1-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-5-(1-isopropyl-piperidin-4-ylcarbamoyl)-1H-pyrazole-3-carbonyl]-(2S)-azetidine-2-carboxylic acid,

2-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-5-(2S,2-hydroxymethyl-pyrrolidine-1-carbonyl)-2H-pyrazole-3-carboxylic acid (1-isopropyl-piperidin-4-yl)-amide,

1-[1-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-5-(1-isopropyl-piperidin-4-ylcarbamoyl)-1H-pyrazole-3-carbonyl]-2S-pyrrolidine-2-carboxylic acid,

2-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-5-(2S,2-methoxymethyl-pyrrolidine-1-carbonyl)-2H-pyrazole-3-carboxylic acid (1-isopropyl-piperidin-4-yl)-amide,

5-(2R,5R,2,5-Bis-methoxymethyl-pyrrolidine-1-carbonyl)-2-[5-(5-chloro-thiophen-2-yl)-isoxazol -3-ylmethyl]-2H-pyrazole-3-carboxylic acid (1-isopropyl-piperidin-4-yl)-amide,

1-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-1H-pyrazole-3,5-dicarboxylic acid 3-[(4,5-dihydro-oxazol-2-yl)-amide]5-[(1-isopropyl-piperidin-4-yl)-amide],

1-[1-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-5-(1-isopropyl-piperidin-4-ylcarbamoyl)-1H-pyrazole-3-carbonyl]-piperidine-4-carboxylic acid ethyl ester,

1-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-1H-pyrazole-3,5-dicarboxylic acid 5-[(1-isopropyl-piperidin-4-yl)-amide]3-[(2-morpholin-4-yl-ethyl)-amide],

2-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-5-(4,4-difluoro-piperidine-1-carbonyl)-2H-pyrazole-3-carboxylic acid (1-isopropyl-piperidin-4-yl)-amide,

2-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-5-(2-oxo-oxazolidine-3-carbonyl)-2H-pyrazole-3-carboxylic acid (1-isopropyl-piperidin-4-yl)-amide,

1-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-1H-pyrazole-3,5-dicarboxylic acid

5-[(1-isopropyl-piperidin-4-yl)-amide]3-{[2-(2-oxo-imidazolidin-1-yl)-ethyl]-amide},

1-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-1H-pyrazole-3,5-dicarboxylic acid 5-[(1-isopropyl-piperidin-4-yl)-amide]3-[(2,2,2-trifluoro-ethyl)-amide], 1-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-1H-pyrazole-3,5-dicarboxylic acid 3-[(1,1-dioxo-tetrahydro-1-thiophen-3-yl)-amide]5-[(1-isopropyl-piperidin-4-yl)-amide],

1-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-1H-pyrazole-3,5-dicarboxylic acid 5-[(1-isopropyl-piperidin-4-yl)-amide]3-{[2-(2-oxo-pyrrolidin-1-yl)-propyl]-amide},

5-(Azetidine-1-carbonyl)-2-[5-(5-chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-2H-pyrazole-3-carboxylic acid (1-isopropyl-piperidin-4-yl)-amide,

2-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-5-(thiazolidine-3-carbonyl)-2H-pyrazole-3-carboxylic acid (1-isopropyl-piperidin-4-yl)-amide,

2-{[1-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-5-(1-isopropyl-piperidin-4-ylcarbamoyl)-1H-pyrazole-3-carbonyl]-amino}-3,3,3-trifluoro-propionic acid,

1-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-1H-pyrazole-3,5-dicarboxylic acid 5-[(1-isopropyl-piperidin-4-yl)-amide]3-trimethylsilanylmethyl-amide,

2-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-5-[4-(2-oxo-pyrrolidin-1-yl)-piperidine-1-carbonyl]-2H-pyrazole-3-carboxylic acid (1-isopropyl-piperidin-4-yl)-amide,

2-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-5-methanesulfonylaminocarbonyl-2H-pyrazole-3-carboxylic acid (1-isopropyl-piperidin-4-yl)-amide,

2-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-5-(3-hydroxy-azetidine-1-carbonyl) -2H-pyrazole-3-carboxylic acid (1-isopropyl-piperidin-4-yl)-amide,

1-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-5-furan-2-yl-1H-pyrazole-3-carboxylic acid (1-isopropyl-piperidin-4-yl)-amide,

2-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-5-(1-isopropyl-piperidin-4-ylcarbamoyl)-2H-pyrazole-3-carboxylic acid,

5-(Azetidine-1-carbonyl)-1-[5-(5-chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-1H-pyrazole-3-carboxylic acid (1-isopropyl-piperidin-4-yl)-amide,

1-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-1H-pyrazole-3,5-dicarboxylic acid 3-[(1-isopropyl-piperidin-4-yl)-amide]5-[(2-sulfamoyl-ethyl)-amide],

1-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-1H-pyrazole-3,5-dicarboxylic acid

3-[bis-(2-hydroxy-ethyl)-amide]5-[(1-isopropyl-piperidin-4-yl)-amide],

1-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-1H-pyrazole-3,5-dicarboxylic acid

3-[(2-hydroxy-1,1-bis-hydroxymethyl-ethyl)-amide]5-[(1-isopropyl-piperidin-4-yl)-amide],

{[1-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-5-(1-isopropyl-piperidin-4-ylcarbamoyl)-1H-pyrazole-3-carbonyl]-amino}-acetic acid isopropyl ester,

1-[(5-Chloro-pyridin-2-ylcarbamoyl)-methyl]-5-(1-isopropyl-piperidin-4-ylcarbamoyl)-1H-pyrazole-3-carboxylic acid ethyl ester,

{[1-[(5-Chloro-pyridin-2-ylcarbamoyl)-methyl]-5-(1-isopropyl-piperidin-4-ylcarbamoyl)-1H-pyrazole-3-carbonyl]-amino}-acetic acid isopropyl ester,

{[1-[(5-Chloro-pyridin-2-ylcarbamoyl)-methyl]-5-(1-isopropyl-piperidin-4-ylcarbamoyl)-1H-pyrazole-3-carbonyl]-amino}-acetic acid ethyl ester,

{[1-[(5-Chloro-pyridin-2-ylcarbamoyl)-methyl]-5-(1-isopropyl-piperidin-4-ylcarbamoyl)-1H-pyrazole-3-carbonyl]-amino}-acetic acid,

2-[(5-Chloro-pyridin-2-ylcarbamoyl)-methyl]-5-(3-hydroxy-azetidine-1-carbonyl)-2H-pyrazole-3-carboxylic acid (1-isopropyl-piperidin-4-yl)-amide,

1-[(5-Chloro-pyridin-2-ylcarbamoyl)-methyl]-5-(1-isopropyl-piperidin-4-ylcarbamoyl)-1H-pyrazole-3-carboxylic acid cyclopropylmethyl ester,

2-{[1-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-5-(1-isopropyl-piperidin-4-ylcarbamoyl)-1H-pyrazole-3-carbonyl]-amino}-3-methyl-butyric acid ethyl ester,

2-{[1-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-5-(1-isopropyl-piperidin-4-ylcarbamoyl)-1H-pyrazole-3-carbonyl]-amino}-3-methyl-butyric acid,

1-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-5-[2-(2-methoxy-ethoxy)-ethoxymethyl]-1H-pyrazole-3-carboxylic acid (1-isopropyl-piperidin-4-yl)-amide,

2-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-5-(2-methoxy-ethoxymethyl)-2H-pyrazole-3-carboxylic acid (1-isopropyl-piperidin-4-yl)-amide,

1-[(5-Chloro-pyridin-2-ylcarbamoyl)-methyl]-5-[2-(2-methoxy-ethoxy)-ethoxymethyl]-1H-pyrazole-3-carboxylic acid (1-isopropyl-piperidin-4-yl)-amide,

2-[(5-Chloro-pyridin-2-ylcarbamoyl)-methyl]-5-[2-(2-methoxy-ethoxy)-ethoxy]-2H-pyrazole-3-carboxylic acid (1-isopropyl-piperidin-4-yl)-amide,

2-[(5-Chloro-pyridin-2-ylcarbamoyl)-methyl]-5-(2,2,2-trifluoro-ethoxy)-2H-pyrazole-3-carboxylic acid (1-isopropyl-piperidin-4-yl)-amide,

1-[(5-Chloro-pyridin-2-ylcarbamoyl)-methyl]-5-(1-isopropyl-piperidin-4-ylcarbamoyl)-1H-pyrazole-3-carboxylic acid 2-methoxy-ethyl ester,

1-[(5-Chloro-pyridin-2-ylcarbamoyl)-methyl]-5-(1-isopropyl-piperidin-4-ylcarbamoyl)-1H-pyrazole-3-carboxylic acid 2-hydroxy-ethyl ester,

2-[(5-Chloro-pyridin-2-ylcarbamoyl)-methyl]-5-([1,4]oxazepane-4-carbonyl)-2H-pyrazole-3-carboxylic acid (1-isopropyl-piperidin-4-yl)-amide,

5-(1-Isopropyl-piperidin-4-ylcarbamoyl)-1-(3-methoxy-benzyl)-1H-pyrazole-3-carboxylic acid,

1-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-5-(1-isopropyl-piperidin-4-ylcarbamoyl)-1H-pyrazole-3-carboxylic acid 2-hydroxy-ethyl ester,

1-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-5-(1-isopropyl-piperidin-4-ylcarbamoyl)-1H-pyrazole-3-carboxylic acid carboxymethyl ester,

1-[(5-Chloro-pyridin-2-ylcarbamoyl)-methyl]-5-(1-isopropyl-piperidin-4-ylcarbamoyl)-4-(2,2,2-trifluoro-ethoxy)-1H-pyrazole-3-carboxylic acid ethyl ester, and

1-[(5-Chloro-pyridin-2-ylcarbamoyl)-methyl]-5-hydroxymethyl-1H-pyrazole-3-carboxylic acid (1-isopropyl-piperidin-4-yl)-amide.

8. A process for the preparation of the compound according to claim 1 , comprising condensing a carboxylic acid of the formula 2

with a compound of the formula HR 8′ or with an amine of the formula HN(R 1′ )R 2′ —V-G-M to give a compound of the formula 3

and optionally converting the compound of formula 3 into a compound of the formula I,

wherein the groups R 8′ and R 87 are respectively the groups —N(R 1 ) —R 2 —V-G-M and R 0 -Q-, which are as defined in claim 1 , R 86 is hydroxyl, (C 1 -C 4 )-alkoxy, acid chloride, a substituted phenyl ester or an N-hydroxysuccinimide or a hydroxybenzotriazole ester, and R 1 a and R 1 b have respectively the meaning of R 3 and R 4 in claim 1 .

9. A pharmaceutical preparation comprising a pharmaceutically effective amount of at least one compound according to claim 1 , or a stereoisomer thereof, mixture of stereoisomers thereof in any ratio, or a physiological tolerable salt thereof, and a pharmaceutically acceptable carrier.

10. A method of inhibiting the activity of factor Xa or factor VIIa comprising contacting an inhibitory amount of the compound according to claim 1 , or a stereoisomer thereof, mixture of stereoisomers thereof in any ratio, or a physiological tolerable salt thereof, with a composition containing factor Xa or factor VIIa to influence blood coagulation, wherein the blood coagulation is connected with abnormal thrombus formation.

11. A method of inhibiting the activity of factor Xa or factor VIIa comprising contacting an inhibitory amount of the compound according to claim 1 , or a stereoisomer thereof, mixture of stereoisomers thereof in any ratio, or a physiological tolerable salt thereof, with a composition containing factor Xa or factor VIIa to influence fibrinolysis.

12. The compound according to claim 5 , having the formula:

or a stereoisomer thereof, mixture of stereoisomers thereof in any ratio, or a physiological tolerable salt thereof.

13. The compound according to claim 12 , wherein:

R 0 is isoxazolyl substituted by 2-thienyl or 3-thienyl, wherein said 2-thienyl or 3-thienyl is unsubstituted or mono- or disubstituted independently of one another by R 8 ;

R 8 is selected from F, Cl, Br, —OCH 3 , —C(O)—NH 2 and —O—CF 3 ;

Q is —(C 1 -C 6 )-alkylene;

R 1 is hydrogen or —(C 1 -C 4 )-alkyl, wherein said alkyl is unsubstituted or substituted one to three times by R 13 ;

R 2 is a direct bond;

V is a piperidine ring, which can be unsubstituted or mono-, di- or trisubstituted independently of one another by R 14 ;

G is a direct bond;

M is (C 1 -C 8 )-alkyl, wherein said alkyl is unsubstituted or independently mono-, di- or trisubstituted by R 14 ;

R 3 and R 4 are selected from hydrogen, halogen, —(C 1 -C 4 )-alkyl, phenyl, —(C 1 -C 3 )-perfluoroalkyl, and —(C 0 -C 2 )-alkylene-O—R 19 wherein said alkyl and/or phenyl is unsubstituted or independently mono-, di- or trisubstituted independently of one another by R 13 ;

R 13 isselected from —(C 1 -C 4 )-alkyl, fluorine, chlorine, —OH, —(C 3 -C 6 )-cycloalkyl, and —(C 1 -C 3 )-perfluoroalkyl;

R 14 is selected from halogen, —OH, and —(C 1 -C 4 )-alkoxy; and

R 19 is selected from hydrogen, —(C 1 -C 4 )-alkyl, or phenyl, wherein alkyl and/or phenyl is unsubstituted or mono-, di- or trisubstituted independently of one another by R 13 .

14. The compound according to claim 13 , wherein the compound is 2-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-4-cyano-5-propyl-2H-pyrazole-3- carboxylic acid (1-isopropyl-piperidin-4-yl)-amide in accordance with the following chemical structure: