Remedy for diabetes
The present invention relates to a therapeutic agent for diabetes with sulfonylurea secondary failure, which contains a GPR40 agonist. According to the present invention, a therapeutic agent for diabetes with sulfonylurea secondary failure that affords a superior insulin secretion effect and a superior hypoglycemic effect even in diabetic patients for whom a sulfonylurea compound or a fast-acting insulin secretagogue fails to provide an insulin secretion effect and therefore, fails to provide a sufficient hypoglycemic effect can be provided.
1. A method for treating type 2 diabetes with sulfonylurea secondary failure in a mammal, which comprises administering an effective amount of a compound represented by the formula:
wherein ring P is an aromatic ring optionally having substituent(s), ring Q is an aromatic ring optionally further having substituent(s) besides —Y—COOH, and X and Y are each independently a spacer,
or a salt thereof, to the mammal.
2. The method of claim 1 , wherein the sulfonylurea secondary failure is caused by a sulfonylurea compound.
3. The method of claim 1 , wherein the sulfonylurea secondary failure is caused by a fast-acting insulin secretagogue.
4. The method of claim 1 , wherein the compound is a compound represented by the formula
wherein ring P 1 is a benzene ring having substituent(s) having a benzene ring, ring Q 1 is a benzene ring optionally having substituent(s), and R is a hydrogen atom or a substituent;
or a salt thereof.
5. The method of claim 4 , wherein
ring P 1 is a benzene ring having substituent(s) represented by the formula: R 1 -E 1 -, wherein R 1 is a phenyl group or an indanyl group, each optionally having substituent(s) selected from the group consisting of halogen atom, nitro group, carboxyl group, optionally halogenated C 1-6 alkyl group, hydroxy-C 1-6 alkyl group, carboxy-C 1-6 alkyl-carbonylamino-C 1-6 alkyl group, optionally halogenated C 1-6 alkoxy group, C 6-14 aryl group, C 6-14 aryloxy group and C 7-16 aralkyloxy group, and E 1 is a bond or a spacer selected from the group consisting of —O—, —CH 2 —O—, —CO—, —CONH—, —N(CH 3 )CH 2 —, —S—CH 2 — and —CH═CH—, and the benzene ring is optionally substituted by C 1-6 alkyl group;
ring Q 1 is a benzene ring optionally having C 1-6 alkyl group; and
R is a hydrogen atom.