Antimicrobial combination therapy
View Patent ↗This invention provides methods and pharmaceutical compositions for treating a subject having a condition associated with an antibiotic resistant bacterial infection. The invention includes administering to a subject a therapeutically effective combination of an antibiotic and a toxic compound (e.g., a nucleic acid damaging agent, an alkylating agent, or a heavy metal containing compound).
1. A method of treating an antibiotic-resistant bacterial infection in a subject, the method comprising administering to a subject suspected of having an antibiotic-resistant bacterial infection a therapeutically effective combination of tetracycline and cisplatin.
2. The method of claim 1 , wherein the antibiotic-resistant bacterial infection is a tetracycline-resistant bacterial infection.
3. The method of claim 1 , wherein the antibiotic-resistant bacterial infection is a multi-drug-resistant bacterial infection.
4. The method of claim 3 , wherein the multi-drug resistance includes tetracycline resistance.
5. The method of claim 1 , wherein the subject is a human.
6. The method of claim 1 , wherein the subject has a condition associated with a bacterial infection selected from the group consisting of a gastrointestinal infection, urogenitary infection, respiratory infection, a skin infection, a systemic infection, a wound infection and a sexually transmitted disease.
7. The method of claim 1 , wherein a pharmaceutical composition comprising tetracycline and cisplatin is administered to the subject.
8. The method of claim 7 , wherein the pharmaceutical composition is administered via a route chosen from oral, parenteral, topical, ocular, transdermal, and nasal routes.
9. The method of claim 7 , wherein the pharmaceutical composition is administered by subcutaneous, intramuscular, intravenous, or epidural injection.
10. A method of killing or inhibiting the growth of antibiotic-resistant bacteria, the method comprising contacting the bacteria with a combination of tetracycline and cisplatin, wherein the combination kills or inhibits growth of the bacteria.
11. The method of claim 10 , wherein the bacteria are is contacted with tetracycline before being contacted with ciplatin.