Nucleic acids and proteins from
The invention provides proteins from group B streptococcus ( Streptococcus agalactiae ) and group A streptococcus ( Streptococcus pyogenes ), including amino acid sequences and the corresponding nucleotide sequences. Data are given to show that the proteins are useful antigens for vaccines, immunogenic compositions, and/or diagnostics. The proteins are also targets for antibiotics.
1. An isolated or recombinant protein comprising a fragment of 100 or more consecutive amino acids from the amino acid sequence SEQ ID NO:6298.
2. The isolated or recombinant protein of claim 1 , wherein the protein binds to antibodies raised against a protein comprising SEQ ID NO:6298.
3. The isolated or recombinant protein of claim 1 , wherein the protein is an isolated protein.
4. The isolated or recombinant protein of claim 1 , wherein the protein is a recombinant protein.
5. A composition comprising an active agent, wherein the active agent is an isolated or recombinant protein comprising a fragment of 100 or more consecutive amino acids from the amino acid sequence SEQ ID NO:6298.
6. The composition of claim 5 which comprises a pharmaceutically acceptable carrier.
7. The composition of claim 5 , wherein the protein binds to antibodies raised against a protein comprising SEQ ID NO:6298.
8. The composition of claim 5 , wherein the protein is an isolated protein.
9. The composition of claim 5 , wherein the protein is a recombinant protein.
10. The composition of claim 6 , wherein the protein binds to antibodies raised against a protein comprising SEQ ID NO:6298.
11. The composition of claim 6 , wherein the protein is an isolated protein.
12. The composition of claim 6 , wherein the protein is a recombinant protein.