Deuterium-enriched SDX-101
The present application describes deuterium-enriched SDX-101, pharmaceutically acceptable salt forms thereof, and methods of treating using the same.
1. A deuterium-enriched compound selected from compounds 1-4:
1
2
3
4
or a pharmaceutically acceptable salt form thereof, wherein R 1-20 , when present, is H or D.
2. A deuterium-enriched compound selected from compounds 5-7:
5
6
7
or a pharmaceutically acceptable salt form thereof.
3. A pharmaceutical composition, comprising: a pharmaceutically acceptable carrier and a therapeutically effective amount of a compound of claim 1 or a pharmaceutically acceptable salt form thereof.
4. A method for treating pain associated with arthritis comprising: administering, to a patient in need thereof, a therapeutically effective amount of a compound of claim 1 or a pharmaceutically acceptable salt form thereof.
5. A deuterium-enriched compound of claim 1 , wherein the compound is of the formula:
or a pharmaceutically acceptable salt form thereof.
6. A deuterium-enriched compound of claim 1 , wherein the compound is of the formula:
or a pharmaceutically acceptable salt form thereof, wherein R 1-2 and R 8-20 are H or D.
7. A deuterium-enriched compound of claim 1 , wherein the compound is of the formula:
or a pharmaceutically acceptable salt form thereof, wherein R 1-7 and R 10-20 are H or D.
8. A deuterium-enriched compound of claim 1 , wherein the compound is of the formula:
or a pharmaceutically acceptable salt form thereof, wherein R 1-9 and R 14-20 are H or D.
9. A deuterium-enriched compound of claim 2 , wherein the compound is of the formula:
or a pharmaceutically acceptable salt form thereof.
10. A deuterium-enriched compound of claim 2 , wherein the compound is of the formula:
or a pharmaceutically acceptable salt form thereof.
11. A deuterium-enriched compound of claim 2 , wherein the compound is of the formula:
or a pharmaceutically acceptable salt form thereof.
12. A pharmaceutical composition, comprising: a pharmaceutically acceptable carrier and a therapeutically effective amount of a compound of claim 2 or a pharmaceutically acceptable salt form thereof.
13. A pharmaceutical composition, comprising: a pharmaceutically acceptable carrier and a therapeutically effective amount of a compound of claim 5 or a pharmaceutically acceptable salt form thereof.
14. A pharmaceutical composition, comprising: a pharmaceutically acceptable carrier and a therapeutically effective amount of a compound of claim 6 or a pharmaceutically acceptable salt form thereof.
15. A pharmaceutical composition, comprising: a pharmaceutically acceptable carrier and a therapeutically effective amount of a compound of claim 7 or a pharmaceutically acceptable salt form thereof.
16. A pharmaceutical composition, comprising: a pharmaceutically acceptable carrier and a therapeutically effective amount of a compound of claim 8 or a pharmaceutically acceptable salt form thereof.
17. A pharmaceutical composition, comprising: a pharmaceutically acceptable carrier and a therapeutically effective amount of a compound of claim 9 or a pharmaceutically acceptable salt form thereof.
18. A pharmaceutical composition, comprising: a pharmaceutically acceptable carrier and a therapeutically effective amount of a compound of claim 10 or a pharmaceutically acceptable salt form thereof.
19. A pharmaceutical composition, comprising: a pharmaceutically acceptable carrier and a therapeutically effective amount of a compound of claim 11 or a pharmaceutically acceptable salt form thereof.
20. A method for treating pain associated with arthritis comprising: administering, to a patient in need thereof, a therapeutically effective amount of a compound of claim 2 or a pharmaceutically acceptable salt form thereof.
21. A method for treating pain associated with arthritis comprising: administering, to a patient in need thereof, a therapeutically effective amount of a compound of claim 5 or a pharmaceutically acceptable salt form thereof.
22. A method for treating pain associated with arthritis comprising: administering, to a patient in need thereof, a therapeutically effective amount of a compound of claim 6 or a pharmaceutically acceptable salt form thereof.
23. A method for treating pain associated with arthritis comprising: administering, to a patient in need thereof, a therapeutically effective amount of a compound of claim 7 or a pharmaceutically acceptable salt form thereof.
24. A method for treating pain associated with arthritis comprising: administering, to a patient in need thereof, a therapeutically effective amount of a compound of claim 8 or a pharmaceutically acceptable salt form thereof.
25. A method for treating pain associated with arthritis comprising: administering, to a patient in need thereof, a therapeutically effective amount of a compound of claim 9 or a pharmaceutically acceptable salt form thereof.
26. A method for treating pain associated with arthritis comprising: administering, to a patient in need thereof, a therapeutically effective amount of a compound of claim 10 or a pharmaceutically acceptable salt form thereof.
27. A method for treating pain associated with arthritis comprising: administering, to a patient in need thereof, a therapeutically effective amount of a compound of claim 11 or a pharmaceutically acceptable salt form thereof.