IP Library › Granted Patent US 7,956,184
Granted Patent B2
US 7,956,184 · App. 12/708,119 · Granted Jun 7, 2011

Pyridazine compound and use thereof

Assignees: Gilead Sciences, Inc.; K.U. Leuven Research & Development; Gerhard Puerstinger
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Quick Facts
Patent No.
US 7,956,184
App. No.
12/708,119
Granted
Jun 7, 2011
Kind
B2
Abstract

A compound of formula (1) and its salts and solvates are provided for the treatment or prophylaxis of hepatitis C virus infections Methods of making and formulating compound (1) are provided.

Claims (4)

1. A method for the preparation of compound (1) comprising providing the intermediate (2)

coupling 2,4-bis(trifluoromethyl)phenylboronic acid to 3-chloro-6-methylpyridazine to produce compound (2a)

treating compound (2a) with a chlorinating agent to produce the alkylating agent (3)

and using alkylating agent (3) to alkylate intermediate (2)under basic conditions to yield compound (1)

Assignments (2)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 4, 2015
From: GILEAD SCIENCES, INC.
To: K.U. LEUVEN RESEARCH & DEVELOPMENT
Reel/Frame 036495/0004 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Apr 2, 2010
From: BONDY, STEVEN S.; DAHL, TERRENCE C.; OARE, DAVID A.; OLIYAI, REZA; TSE, WINSTON C.; ZIA, VAHID
To: GILEAD SCIENCES, INC.; K. U. LEUVEN RESEARCH & DEVELOPMENT; PUERSTINGER, GERHARD
Reel/Frame 024180/0075 →
Continuity (5)
Division 11825598 · Jul 6, 2007
Provisional Application 60819289 · Jul 7, 2006
Provisional Application 60832403 · Jul 21, 2006
Provisional Application 60832769 · Jul 24, 2006
Related Publication 20100152444A1 · Jun 17, 2010