Compounds and methods for treatment and prevention of diseases
A prodrug compound of a rapamycin analog and methods for inhibiting, treating, and preventing mammalian diseases.
1. A compound of formula:
wherein R is R 1 C(O)R 2 R 3 or R 1 C(S)R 2 R 3 and wherein,
R 1 is O or S;
R 2 is a valence bond, O, NH or S; and
R 3 is alkyl, alkenyl, alkynyl, or aryl.
2. A method for inhibiting or treating restenosis, intimal smooth muscle cell hyperplasia, and vascular occulation in a mammal in need of treatment using the compound of claim 1 .
3. A method for treating post-transplant-tissue transplant rejection in a mammal in need of treatment using the compound of claim 1 .
4. A method for inhibiting or treating fungal growth in a mammal in need of treatment using the compound of claim 1 .
5. The compound of claim 1 , wherein R is OC(O)R 2 R 3 , wherein R 2 is a valence bond and R 3 is alkyl, alkenyl, alkenyl, or aryl.
6. A pharmaceutical composition comprising the compound of claim 1 and a pharmaceutically acceptable carrier or excipient.