IP Library › Granted Patent US 8,007,812
Granted Patent B2
US 8,007,812 · App. 11/722,682 · Granted Aug 30, 2011

Flagellin related polypeptides and uses thereof

Assignee: Cleveland Clinic Foundation
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Quick Facts
Patent No.
US 8,007,812
App. No.
11/722,682
Granted
Aug 30, 2011
Kind
B2
Abstract

The use of flagellin and flagellin related polypeptides for the protection of mammals from the effects of apoptosis is described.

Claims (3)

1. A method of protecting a mammal from gastrointestinal and hematopoietic radiation syndromes comprising administering to a mammal in need thereof a composition comprising a flagellin polypeptide, wherein the polypeptide comprises the amino acid sequence of SEQ ID NO: 8.

2. The method of claim 1 , wherein the composition is administered prior to, together with, or after said radiation.

3. The method of claim 1 , wherein the composition is administered in combination with a radioprotectant.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded May 29, 2013
From: GUDKOV, ANDREI V.; DIDONATO, JOSEPH A.; KRIVOKRYSENKO, VADIM
To: CLEVELAND CLINIC FOUNDATION
Reel/Frame 030501/0502 →
Continuity (2)
Provisional Application 60639826 · Dec 22, 2004
Related Publication 20090011982A1 · Jan 8, 2009