Pyridine and pyrazine derivatives -083

1. A compound of Formula I

wherein:

W is N;

n is O

J is O;

each of G 1 , G 2 , G 3 and G 4 is CH or N provided that not more than two of G 1 , G 2 , G 3 and G 4 represent N;

Ring A is phenyl substituted by R 1 ;

R 1 is a group of the formula Q 1 -X 2 —;

wherein X 2 is a direct bond or is selected from O, SO, SO 2 , N(R 7 ), N[C(O)R 7 ], N[C(O)N(R 7 ) 2 ], N[C(O)OR 7 ], N[SO 2 —N(R 7 ) 2 ], CO, CON(R 7 ), N(R 7 )CO, SO 2 N(R 7 ), N(R 7 )SO 2 , O—SO 2 , SO 2 —O, C(R 7 ) 2 O, OC(R 7 ) 2 , C(R 7 ) 2 , C(R 7 ) 2 N(R 7 ) and N(R 7 )C(R 7 ) 2 , wherein each R 7 is independently hydrogen or (1-8C)alkyl;

and Q 1 is heterocyclyl, or heterocyclyl-(1-3C)alkyl, wherein said heterocyclyl or the heterocyclyl within the heterocyclyl-(1-3C)alkyl group is piperazinyl; and

R 3 is hydrogen;

or a pharmaceutically acceptable salt thereof.

2. A compound according to claim 1 , wherein:

n is O

W is N;

J is O;

G 2 is N or CH and G 1 , G 3 and G 4 are CH;

Ring A is phenyl substituted by R 1 ;

R 1 is a group of the formula:

Q 1 -Q 2 -

wherein X 2 is a direct bond or CO;

and Q 1 is heterocyclyl, or heterocyclyl-(1-3C)alkyl, wherein said heterocyclyl or the heterocyclyl within the heterocyclyl-(1-3C)alkyl group is piperazinyl; and

R 3 is hydrogen;

or a pharmaceutically acceptable salt thereof.

3. A compound of Formula I according to claim 2 which is:

3-(1,3-benzoxazol-2-yl)-5 43-(4-methylpiperazin-1-yl)phenyl]pyrazin-2-amine;

3-(1,3-benzoxazol-2-yl)-5-(4-piperazin-1-ylphenyl)pyrazin-2-amine; or

3-(1,3-benzoxazol-2-yl)-5-(3-piperazin-1-ylphenyl)pyrazin-2-amine;

or a pharmaceutically acceptable salt of a foregoing compound.

4. A pharmaceutical composition, which comprises a compound of Formula I, or a pharmaceutically acceptable salt thereof, according to claim 1 in association with a pharmaceutically acceptable diluent or carrier.