Lipids, lipid complexes and use thereof
The present invention is related to a compound according to formula (I), wherein R 1 and R 2 are each and independently selected from the group comprising alkyl; n is any integer between 1 and 4; R 3 is an acyl selected from the group comprising lysyl, ornithyl, 2,4-diaminobutyryl, histidyl and an acyl moiety according to formula (II), wherein m is any integer from 1 to 3 and YÉ is a pharmaceutically acceptable anion.
1. A compound according to formula (I),
wherein R 1 and R 2 are each and independently selected from the group consisting of alkyl;
n is any integer between 1 and 4;
R 3 is an acyl selected from the group consisting of lysyl, ornithyl, 2,4-diaminobutyryl, histidyl and an acyl moiety according to formula (II),
wherein m is any integer from 1 to 3 and
Y − is a pharmaceutically acceptable anion.
2. The compound according to claim 1 , wherein R 1 and R 2 are each and independently selected from the group consisting of lauryl, myristyl, palmityl and oleyl.
3. The compound according to claim 1 , wherein R 1 is lauryl and R 2 is myristyl; or
R 1 is palmityl and R 2 is oleyl.
4. The compound according to claim 1 , wherein m is 1 or 2.
5. The compound according to claim 1 , wherein the compound is a cationic lipid.
6. The compound according to claim 1 , wherein Y − is selected from the group consisting of halogenids, acetate and trifluoroacetate.
7. The compound according to claim 1 , wherein the compound is selected from the group consisting of:
β-arginyl-2,3-diamino propionic acid-N-palmityl-N-oleyl-amide trihydrochloride
β-arginyl-2,3-diamino propionic acid-N-lauryl-N-myristyl-amide trihydrochloride
ε-arginyl-lysine-N-lauryl-N-myristyl-amide trihydrochloride