IP Library › Granted Patent US 8,018,596
Granted Patent B2
US 8,018,596 · App. 12/800,860 · Granted Sep 13, 2011

Interactive variable pathlength device

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Quick Facts
Patent No.
US 8,018,596
App. No.
12/800,860
Granted
Sep 13, 2011
Kind
B2
Abstract

This disclosure relates generally to a sampling device, and more particularly, a sampling device that facilitates spectroscopic measurements with a variable path length and the necessary software controlled algorithms and methods for such a device.

Claims (33)

1. An instrument for measuring the absorbance of a flowing sample at multiple path lengths comprising:

(a) a light source operably linked to a probe;

(b) a sample vessel through which the sample flows;

(c) a motor that moves the sample vessel relative to the probe to provide variable path lengths;

(d) a probe that carries electromagnetic radiation that moves relative to the sample vessel by the motor;

(e) a unidirectional sliding mechanism which permits physical contact between the probe and sample vessel; and

(f) a detector located below the sample vessel that can detect electromagnetic radiation disposed such that the detector is substantially perpendicular to the electromagnetic radiation emanating from the probe and such that the electromagnetic radiation moves through the sample and is detected by the detector.

2. The instrument of claim 1 wherein the flow through sample vessel comprises:

(a) a flow cell body through which a sample solution may pass comprising:

(b) an inlet port through which the solution enters the flow cell body;

(c) an outlet port through which the solution exits the flow cell body;

(d) at least one transparent window where a detector is placed adjacent to the window; and

(e) a port comprising a seal disposed opposite to the window such that light passes from the probe through the sample solution and through the window wherein a probe may pass through the seal and move relative to the window without the sample solution leaking from the port.

3. The instrument of claim 1 wherein the motor is operably linked to the probe.

4. The instrument of claim 1 wherein the motor is operably linked to the vessel.

5. The instrument of claim 1 wherein the unidirection sliding mechanism is operably linked to the probe.

6. The instrument of claim 1 wherein the unidirectional sliding mechanism is operably linked to the vessel.

7. The instrument of claim 2 wherein the motor is operably linked to the probe.

8. The instrument of claim 2 wherein the motor is operably linked to the vessel.

9. The instrument of claim 2 wherein the unidirection sliding mechanism is operably linked to the probe.

10. The instrument of claim 2 wherein the unidirectional sliding mechanism is operably linked to the vessel.

11. An instrument for determine the concentration of a flowing sample at multiple path lengths comprising:

(a) a light source operably linked to a probe;

(b) a sample vessel through which the sample flows;

(c) a motor that moves the sample vessel relative to the probe to provide variable path lengths;

(d) a probe that carries electromagnetic radiation that moves relative to the sample vessel by the motor;

(e) a unidirectional sliding mechanism which permits physical contact between the probe and sample vessel; and

(f) a detector located below the sample vessel that can detect electromagnetic radiation disposed such that the detector is substantially perpendicular to the electromagnetic radiation emanating from the probe and such that the electromagnetic radiation moves through the sample and is detected by the detector;

(g) software for calculating the concentration of the sample based on the information provided by the detector at the predetermined path lengths.

12. The instrument of claim 11 wherein the motor is operably linked to the probe.

13. The instrument of claim 11 wherein the motor is operably linked to the vessel.

14. The instrument of claim 11 wherein the unidirection sliding mechanism is operably linked to the probe.

15. The instrument of claim 11 wherein the unidirectional sliding mechanism is operably linked to the vessel.

Assignments (2)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded May 2, 2025
From: C TECHNOLOGIES INC.
To: REPLIGEN CORPORATION
Reel/Frame 071004/0948 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 27, 2017
From: SALERNO, MARK; SHIH, I TSUNG; HARRISON, CRAIG
To: C TECHNOLOGIES INC.
Reel/Frame 042822/0843 →
Continuity (3)
Continuation 12100467 · Apr 10, 2008
Provisional Application 60923179 · Apr 13, 2007
Related Publication 20110013190A1 · Jan 20, 2011