Cyclopropyl amines as modulators of the histamine H
View Patent ↗Certain cyclopropyl amines are histamine H 3 modulators useful in the treatment of histamine H 3 receptor mediated diseases.
1. A compound that is (4-cyclopropyl-piperazin-1-yl)-[4-(4-fluoro-piperidin-1-ylmethyl)-phenyl]-methanone, or enantiomers or pharmaceutically acceptable salts thereof.
2. A compound of claim 1 that is (4-cyclopropyl-piperazin-1-yl)-[4-(4-fluoro-piperidin-1-ylmethyl)-phenyl]-methanone or a pharmaceutically acceptable salt thereof.
3. A compound that is (4-cyclopropyl-piperazin-1-yl)-[4-(4-fluoro-piperidin-1-ylmethyl)-phenyl]-methanone citrate salt.
4. A pharmaceutical composition comprising a pharmaceutically acceptable carrier and an effective amount of (4-cyclopropyl-piperazin-1-yl)-[4-(4-fluoro-piperidin-1-ylmethyl)-phenyl]-methanone, or enantiomers or pharmaceutically acceptable salts thereof.
5. A pharmaceutical composition according to claim 4 , further comprising topiramate.