IP Library › Granted Patent US 8,053,560
Granted Patent B2
US 8,053,560 · App. 11/927,247 · Granted Nov 8, 2011

Modified human plasma polypeptide or Fc scaffolds and their uses

Assignee: Ambrx, Inc.
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Quick Facts
Patent No.
US 8,053,560
App. No.
11/927,247
Granted
Nov 8, 2011
Kind
B2
Abstract

Modified human plasma polypeptides or Fc and uses thereof are provided.

Claims (5)

1. A human serum albumin (HSA) comprising a non-naturally encoded amino acid at one of the following positions: 34, 82, 172, 301, 364, and 505 of SEQ ID NO:1, linked to glucagon or a glucagon-like peptide.

2. The HSA of claim 1 , wherein the non-naturally encoded amino acid is para-acetylphenylalanine.

3. The HSA of claim 1 , wherein the non-naturally encoded amino acid is para-amino-phenylalanine.

4. The HSA of claim 1 , wherein the glucagon-like peptide is glucagon-like peptide-1 (GLP-1).

5. The HSA of claim 1 , wherein the glucagon-like peptide is glucagon-like peptide-2 (GLP-2).

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Mar 13, 2008
From: SHEFFER, JOSEPH; NORMAN, THEA; DIMARCHI, RICHARD D.; HAYS PUTNAM, ANNA-MARIA A.; TIAN, FENG; CHU, STEPHANIE; KRAWITZ, DENISE; CHO, HO SUNG
To: AMBRX, INC.
Reel/Frame 020648/0905 →
Continuity (4)
Continuation PCTUS2007019528 · Sep 7, 2007
Provisional Application 60843215 · Sep 8, 2006
Provisional Application 60928485 · May 8, 2007
Related Publication 20080113411A1 · May 15, 2008