Modified green tea polyphenol formulations
View Patent ↗Modified green tea polyphenols and methods of their use are provided. One aspect provides compounds and compositions containing green tea polyphenols with one on more ester-linked fatty acids.
1. A composition comprising:
(a) one or more compounds according to Formula II:
Wherein R 1 , R 2 , R 3 , R 4 , R 7 , R 8 , R 9 , and R 10 are each independently H, OH,
R 11 is a linear, branched, or cyclic, saturated or unsaturated, substituted or unsubstituted C 1 -C 30 group, wherein if R 11 is cyclic, R 11 is a C 3 -C 30 group;
R 5 is O, —NR 12 R 13 or S, wherein R 12 and R 13 are independently hydrogen, or a linear, branched, or cyclic, saturated or unsaturated, substituted or unsubstituted C 1 -C 30 group, wherein if R 12 and/or R 13 are cyclic, R 12 and/or R 13 are C 3 -C 30 groups;
R 6 is independently O or S;
wherein at least one of R 1 , R 2 , R 3 , R 4 , R 7 , R 8 , R 9 , or R 10 are independently
provided R 4 is not
when R 1 , R 2 , R 3 , R 7 , R 8 , R 9 , and R 10 are OH; or a pharmaceutically acceptable salt thereof; and
(b) an excipient.
2. A composition according to claim 1 , wherein
one or more compounds according to Formula II are in an amount effective to reduce skin inflammation or dandruff.
3. The composition of claim 1 wherein at least two of R 1 , R 2 , R 3 , R 4 , R 7 , R 8 , R 9 , and R 10 are independently
4. The composition of claim 1 wherein at least three of R 1 , R 2 , R 3 , R 4 , R 7 , R 8 , R 9 , and R 10 are independently
5. The composition of claim 1 wherein at least four of R 1 , R 2 , R 3 , R 4 , R 7 , R 8 , R 9 , and R 10 are independently
6. A compound according to formula II:
wherein R 1 , R 2 , R 3 , R 4 , R 7 , R 8 , R 9 , and R 10 are each independently H, OH,
R 11 is a linear, branched, or cyclic, saturated or unsaturated, substituted or unsubstituted C 1 -C 30 group, wherein if R 11 is cyclic, R 11 is a C 3 -C 30 group;
R 5 is O, —NR 12 R 13 or S, wherein R 12 and R 13 are independently hydrogen, or a linear, branched, or cyclic, saturated or unsaturated, substituted or unsubstituted C 1 -C 30 group, wherein if R 12 and/or R 13 are cyclic, R 12 and/or R 13 are C 3 -C 30 groups;
R 6 is independently O or S;
wherein at least one of R 1 , R 2 , R 3 , R 4 , R 7 , R 8 , R 9 , or R 10 are independently
provided R 4 is not
when R 1 , R 2 , R 3 , R 7 , R 8 , R 9 , and R 10 are OH;
or a pharmaceutically acceptable salt thereof.
7. A composition comprising the compound claim 6 in combination with an excipient.
8. An emulsion comprising one or more compounds according to claim 6 .