N-hydroxyamide derivatives possessing antibacterial activity
Described herein are N-hydroxyamide antibacterial compounds, methods for making the compounds, pharmaceutical compositions containing the compounds and methods of treating bacterial infections utilizing the compounds and pharmaceutical compositions compound of Formula (I): or a salt, solvate ti hydrate thereof, wherein A is (a) each indicates a point of attachment.
1. A compound having the formula
or a salt, thereof,
wherein R 1 is selected from the group consisting of H, N 3 , NH 2 , NHSO 2 CH 3 , NHCOH, NHCH 3 , F, and OCH 3 ;
R 2 is selected from the group consisting of H, and NH 2 ;
R 3 is selected from the group consisting of H, and CH 2 OCH 3 , and;
Ar is represented by
2. The compound of claim 1 wherein R 1 is H, and R 3 is CH 2 OCH 3 .
3. The compound of claim 1 wherein R 1 is selected from the group consisting of N 3 , NH 2 , NHSO 2 CH 3 , NHCOH, NHCH 3 , F and OCH 3 ; R 2 is H and R 3 is H.
4. The compound of claim 3 wherein R 1 is NH 2 .
5. The compound of claim 1 wherein R 2 is NH 2 and R 3 is H.
6. A method of treating a bacterial infection in a mammal in need thereof comprising administering an effective amount of a compound of claim 1 to the mammal.
7. The compound of claim 1 in which R 1 , R 2 and R 3 are each represented by H.