Organic compounds

1. A compound of Formula (I):

wherein

X is ═C(R 8 )—;

Y is ═N—;

R 1 and R 2 are each independently selected from R 10 , —OR 10 , —C(O)R 10 , —C(O)OR 10 and —S(O) 1 R 10 ;

R 3 and R 4 are each independently hydrogen or R 13 ; or R 3 and R 4 taken together with the carbon atom to which they are attached form carbocyclyl or heterocyclyl, either of which is optionally substituted with 1, 2, 3, 4 or 5 R 13 ;

R 5 is aryl or heteroaryl, either of which is optionally substituted with 1, 2, 3, 4 or 5 R 13 ;

R 6 is selected from halogen, trifluoromethyl, cyano, nitro, R 10 , —OR 10 , —C(O)R 10 , —C(O)OR 10 , —OC(O)R 10 , —S(O) 1 R 11 , —N(R 11 )(R 12 ) and —C(O)N(R 11 )(R 12 );

R 7 , R 8 and R 9 are each independently selected from hydrogen, halogen and moieties comprising from 1 to 30 plural valent atoms selected from C, N, O and S; for example R 7 , R 8 and R 9 are each independently selected from halogen, trifluoromethyl, cyano, nitro, R 10 , —OR 10 , —C(O)R 10 , —C(O)OR 10 , —OC(O)R 10 , —S(O) l R 11 , —N(R 11 )(R 12 ) and —C(O)N(R 11 )(R 12 );

R 10 is hydrogen, hydrocarbyl optionally substituted with 1, 2, 3, 4 or 5 R 13 ; or —(CH 2 ) k -heterocyclyl optionally substituted with 1, 2, 3, 4 or 5 R 13 ;

R 11 and R 12 are each independently selected from R 10 , —OR 10 , —C(O)R 10 , —C(O)OR 10 , —(CH 2 ) k —R 10 , —C(O)—(CH 2 ) k —R 10 and —S(O) l R 10 ; or R 11 and R 12 taken together with a nitrogen atom to which they are attached form heterocyclyl optionally substituted with 1, 2, 3, 4 or 5 R 13 ;

each R 13 is independently selected from halogen, trifluoromethyl, cyano, nitro, oxo,═NR 14 , —OR 14 , —C(O)R 14 , —C(O)OR 14 , —OC(O)R 14 , —S(O) l R 14 , —N(R 14 )R 15 , —C(O)N(R 14 )R 15 and R 16 ;

R 14 and R 15 are each independently hydrogen or R 16 ;

R 16 is selected from a spiro group, hydrocarbyl, —(CH 2 ) k -hydrocarbyl, —(CH 2 ) k -heterocyclyl and —(CH 2 ) k —C(O)heterocyclyl, either of which is optionally substituted with 1, 2, 3, 4 or 5 substituents independently selected from halogen, cyano, oxo, amino, hydroxy, —C(O)—C 1-6 alkyl, C 1-6 alkyl and 1-6 alkoxy;

j is 0, 1 or 2;

k is 0, 1, 2, 3, 4, 5 or 6; and

l is 0, 1, or 2;

or a pharmaceutically acceptable salt thereof.

2. The compound according to claim 1 , wherein;

R 11 and R 12 are each independents selected from R 10 , —OR 10 , —C(O)R 10 , —C(O)OR 10 and —S(O) l R 10 ; or R 11 and R 12 taken together with a nitrogen atom to which they are attached form heterocyclyl optionally substituted with 1, 2, 3, 4 or 5 R 13 ; and

R 16 is selected from hydrocarbyl and —(CH 2 ) k -heterocyclyl, either of which is optionally substituted with 1, 2, 3, 4 or 5 substituents independents selected from halogen, cyano, amino, hydroxy, C 1-6 alkyl and C 1-6 alkoxy;

or a pharmaceutically acceptable salt thereof.

3. The compound according to claim 1 , which is of the Formula (II):

or a pharmaceutically acceptable salt thereof.

4. The compound according to claim 3 , wherein R 8 is hydrogen.

5. The compound according to claim 1 , wherein R 1 and R 2 are each independently selected from hydrogen, C 1-6 alkyl optionally substituted with 1, 2, 3, 4 or 5 R 13 , and —(CH 2 ) k -carbocyclyl optionally substituted with 1, 2, 3, 4 or 5 R 13 .

6. The compound according to claim 5 , wherein R 1 and R 2 are each hydrogen.

7. The compound according to claim 1 , wherein R 3 and R 4 are each independently selected from hydrogen, C 1-6 alkyl optionally substituted with 1, 2, 3, 4 or 5 R 13 , and —(CH 2 ) k -carbocyclyl optionally substituted with 1, 2, 3, 4 or 5 R 13 .

8. The compound according to claim 7 , wherein R 3 and R 4 are each hydrogen.

9. The compound according to claim 1 , wherein R 1 , R 2 , R 3 and R 4 are each hydrogen.

10. The compound according to claim 1 , wherein R 5 is aryl optionally substituted with 1, 2, 3, 4 or 5 R 13 .

11. The compound according to claim 10 , wherein R 5 is phenyl optionally substituted with 1, 2, 3, 4 or 5 R 13 .

12. The compound according to claim 11 , wherein R 5 is phenyl optionally substituted with 1, 2 or 3 substituents independents selected from halogen, cyano, amino, hydroxy, C 1-6 alkyl and C 1-6 alkoxy.

13. The compound according to claim 12 , wherein R 5 is phenyl comprising substituents at the 2- and 4- positions, wherein the substituents are independently selected from halogen, methyl and methoxy.

14. The compound according to claim 13 , wherein R 5 is 2,4-dichlorophenyl.

15. The compound according to claim 1 , selected from:

or, in each case, a pharmaceutically acceptable salt free form thereof.

16. A pharmaceutical formulation, comprising:

a compound of claim 1 , and

a pharmaceutically acceptable excipient or carrier.

17. A formulation according to claim 16 , which further comprises a therapeutic agent selected from antidiabetic agents, hypolipidemic agents, anti-obesity or appetite-regulating agents, anti-hypertensive agents, HDL-increasing agents, cholesterol absorption modulators, Apo-A1 analogues and mimetics, thrombin inhibitors, aldosterone inhibitors, inhibitors of platelet aggregation, estrogen, testosterone, selective estrogen receptor modulators, selective androgen receptor modulators, chemotherapeutic agents, and 5-HT 3 or 5-HT 4 receptor modulators; or pharmaceutically acceptable salts thereof.