IP Library › Granted Patent US 8,101,608

Granted Patent B2

US 8,101,608 · App. 11/718,886 · Granted Jan 24, 2012

Compounds and compositions as protein kinase inhibitors

Assignee: IRM LLC, a Delware Limited Corporation

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Quick Facts

Patent No.: US 8,101,608
App. No.: 11/718,886
Granted: Jan 24, 2012
Kind: B2

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Abstract

The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of the Abl, Bcr-Abl, cSrc, TPR-Met, Tie2, MET, FGFR3, Aurora, Axl, Bmx, BTK, c-kit, CHK2, Flt3, MST2, p70S6K, PDGFR, PKB, PKC, Raf, ROCK-II, Rsk1, SGK, TrkA, TrkB and TrkC kinases.

Claims (273)

1. A compound of Formula I:

in which:

U, V and W are independently selected from CR 5 and N;

Q is selected from N, NNR 5 , NO and CR 5 ;

L 1 is selected from —NR 5 C(O)—, —NR 5 C(O)NR 5 —, —C(O)NR 5 —, —NR 5 — and C 5-10 heteroaryl;

L 2 is selected from —O—, —NR 5 C(O)—, —NR 5 C(O)NR 5 —, —C(O)NR 5 — and —NR 5 —;

n is selected from 0 and 1;

m is selected from 0, 1, 2, 3 and 4;

R 1 is selected from C 6-10 aryl, C 5-10 heteroaryl, C 3-12 cycloalkyl and C 3-8 heterocycloalkyl;

wherein any aryl, heteroaryl, cycloalkyl or heterocycloalkyl of R 1 is optionally substituted by one to three radicals independently selected from halo, amino, nitro, cyano, C 1-6 alkyl, C 1-6 alkoxy, halo-substituted-C 1-6 alkyl, halo-substituted C 1-6 alkoxy, C 6-10 aryl-C 0-4 alkyl, C 5-10 heteroaryl-C 0-4 alkyl, C 3-12 cycloalkyl-C 0-4 alkyl and C 3-8 heterocycloalkyl-C 0-4 alkyl; wherein a methylene of any alkyl group can be optionally replaced by oxygen;

wherein any aryl, heteroaryl, cycloalkyl or heterocycloalkyl substituent of R 1 can be optionally substituted by 1 to 3 radicals independently selected from C 1-6 alkyl, C 1-6 alkoxy, halo-substituted-C 1-6 alkyl, halo-substituted C 1-6 alkoxy and hydroxy-substituted-C 1-6 alkyl;

R 2 is selected from halo, amino, nitro, cyano, C 1-6 alkyl, C 1-6 alkoxy, halo-substituted-C 1-6 alkyl, halo-substituted C 1-6 alkoxy, C 6-10 aryl-C 0-4 alkyl, C 5-10 heteroaryl-C 0-4 alkyl, C 3-12 cycloalkyl-C 0-4 alkyl and C 3-8 heterocycloalkyl-C 0-4 alkyl; wherein any aryl, heteroaryl, cycloalkyl or heterocycloalkyl of R 2 is optionally substituted by one to three radicals independently selected from halo, amino, nitro, cyano, C 1-6 alkyl, C 1-6 alkoxy, halo-substituted-C 1-6 alkyl and halo-substituted C 1-6 alkoxy;

R 3 is selected from hydrogen and C 1-6 alkyl; and

R 4 is selected from hydrogen, —R 6 , —NR 5 R 6 , and —OR 6 ;

R 5 is selected from hydrogen and C 1-6 alkyl; and

R 6 is selected from pyrrolyl, imidazolyl, indolyl, furanyl, thiazolyl, and cyclopentyl, each of which is optionally substituted with 1 to 3 radicals independently selected from C 1-6 alkyl, hydroxy, cyano, —NR 5 S(O) 0-2 R 5 , —S(O) 0-2 NR 5 R 5 , —NR 5 S(O) 0-2 NR 5 R 5 , —C(O)NR 5 XNR 5 R 5 , —XNR 5 XNR 5 R 5 , —C(O)R 7 , —C(O)NR 5 XOR 5 , —C(O)NR 5 R 5 , —C(O)NR 5 R 7 , —C(O)NR 5 XR 7 and —XC(O)OR 5 ; wherein each X is independently selected from a bond and C 1-4 alkylene; wherein any alkylene of X can be optionally substituted with hydroxy; and

R 7 is C 3-10 heterocycloalkyl-C 0-4 alkyl optionally substituted with a radical selected from dimethylamino, pyrimidinyl, pyrazinyl, diethylamino-ethyl, amino and methyl;

or the pharmaceutically acceptable salts, thereof.

2. The compound of claim 1 in which:

W is CH;

L 1 is selected from —NR 5 C(O)—, —C(O)NR 5 —, —NR 5 C(O)NR 5 —, and C 5-10 heteroaryl;

m is selected from 0, 1, 2 and 3;

R 1 is selected from C 6-10 aryl and C 5-10 heteroaryl;

wherein any aryl or heteroaryl is optionally substituted by one to three radicals independently selected from halo, C 1-6 alkyl, halo-substituted-C 1-6 alkyl, C 5-10 heteroaryl-C 0-4 alkyl and C 3-8 heterocycloalkyl-C 0-4 alkyl; wherein a methylene of any alkyl group can be optionally replaced by oxygen;

wherein any heteroaryl or heterocycloalkyl substituent of R 1 can be optionally substituted by 1 to 3 radicals independently selected from C 1-6 alkyl and hydroxy-substituted-C 1-6 alkyl;

R 2 is selected from C 1-6 alkyl, C 1-6 alkoxy, halo-substituted-C 1-6 alkyl and C 3-8 heterocycloalkyl-C 0-4 alkyl optionally substituted by 1 to 3 C 1-6 alkyl radicals; and

R 6 is selected from pyrrolyl, imidazolyl, indolyl, furanyl, thiazolyl, and cyclopentyl.

3. The compound of claim 2 in which:

L 1 is selected from —NHC(O)—, —C(O)NH—, —NHC(O)NH—, and [1,2,4]oxadiazole;

L 2 is selected from —O—, —NHC(O)—, —NHC(O)NH—, —C(O)NH— and —NH—; and

n is 1; and

m is selected from 0 and 1.

4. The compound of claim 3 in which R 1 is selected from phenyl, indolyl and pyrazolyl; wherein any phenyl, indolyl or pyrazolyl is optionally substituted by one to three radicals independently selected from halo, methyl, trifluoromethyl, tert-butyl, morpholino, piperazinyl, piperazinyl-oxy, piperazinyl-methyl, piperidinyl, piperidinyl-oxy and imidazolyl; wherein any heteroaryl or heterocycloalkyl substituent of R 1 can be optionally substituted by 1 to 3 radicals independently selected from methyl, ethyl, hydroxy and hydroxy-ethyl.

5. The compound of claim 4 in which R 2 is selected from methyl, methoxy, trifluoromethyl and imidazolyl optionally substituted by methyl.

6. The compound of claim 5 in which

R 6 is pyrrolyl.

7. A compound selected from:

3-(4-Methyl-imidazol-1-yl)-N-{3-[2-oxo-3-(1H-pyrrol-2-ylmethylene)-2,3-dihydro-1H-indol-6-ylamino]-phenyl}-5-trifluoromethyl-benzamide;

N-[2-Oxo-3-(1H-pyrrol-2-ylmethylene)-2,3-dihydro-1H-indol-6-yl]-benzamide;

5-(6-Benzoylamino-2-oxo-1,2-dihydro-indol-3-ylidenemethyl)-2,4-dimethyl-1H-pyrrole-3-carboxylic acid (2-diethylamino-ethyl)-amide;

3-(4-Methyl-imidazol-1-yl)-N-(3-{3-[2-oxo-3-(1H-pyrrol-2-ylmethylene)-2,3-dihydro-1H-indol-6-yl]-ureido}-phenyl)-5-trifluoromethyl-benzamide;

2-Oxo-3-(1H-pyrrol-2-ylmethylene)-2,3-dihydro-1H-indole-6-carboxylic acid (3-benzoylamino-phenyl)-amide;

6-(3-Amino-phenylamino)-3-(1H-pyrrol-2-ylmethylene)-1,3-dihydro-indol-2-one;

4-(4-Methyl-piperazin-1-ylmethyl)-N-{3-[2-oxo-3-(1H-pyrrol-2-ylmethylene)-2,3-dihydro-1H-indol-7-ylamino]-phenyl}-benzamide;

4-(4-Methyl-piperazin-1-ylmethyl)-N-{3-[2-oxo-3-(1H-pyrrol-2-ylmethylene)-2,3-dihydro-1H-indol-5-ylamino]-phenyl}-benzamide;

4-(4-Ethyl-piperazin-1-ylmethyl)-N-{3-[2-oxo-3-(1H-pyrrol-2-ylmethylene)-2,3-dihydro-1H-indol-6-ylamino]-phenyl}-3-trifluoromethyl-benzamide;

3-(4-Methyl-piperazin-1-yl)-N-{3-[2-oxo-3-(1H-pyrrol-2-ylmethylene)-2,3-dihydro-1H-indol-6-yloxy]-phenyl}-5-trifluoromethyl-benzamide;

5-(6-Benzoylamino-2-oxo-1,2-dihydro-indol-3-ylidenemethyl)-2,4-dimethyl-1H-pyrrole-3-carboxylic acid (2-pyrrolidin-1-yl-ethyl)-amide;

5-(6-Benzoylamino-2-oxo-1,2-dihydro-indol-3-ylidenemethyl)-2,4-dimethyl-1H-pyrrole-3-carboxylic acid (2-piperidin-1-yl-ethyl)-amide;

5-(6-Benzoylamino-2-oxo-1,2-dihydro-indol-3-ylidenemethyl)-2,4-dimethyl-1H-pyrrole-3-carboxylic acid (3-pyrrolidin-1-yl-propyl)-amide;

N-[2-Oxo-3-(1H-pyrrol-2-ylmethylene)-2,3-dihydro-1H-indol-6-yl]-3-trifluoromethyl-benzamide;

3-{2,4-Dimethyl-5-[2-oxo-6-(3-trifluoromethyl-benzoylamino)-1,2-dihydro-indol-3-ylidenemethyl]-1H-pyrrol-3-yl}-propionic acid;

2,4-Dimethyl-5-[2-oxo-6-(3-trifluoromethyl-benzoylamino)-1,2-dihydro-indol-3-ylidenemethyl]-1H-pyrrole-3-carboxylic acid;

2,4-Dimethyl-5-[2-oxo-6-(3-trifluoromethyl-benzoylamino)-1,2-dihydro-indol-3-ylidenemethyl]-1H-pyrrole-3-carboxylic acid (2-dimethylamino-ethyl)-amide;

2,4-Dimethyl-5-[2-oxo-6-(3-trifluoromethyl-benzoylamino)-1,2-dihydro-indol-3-ylidenemethyl]-1H-pyrrole-3-carboxylic acid (2-pyrrolidin-1-yl-ethyl)-amide;

2,4-Dimethyl-5-[2-oxo-6-(3-trifluoromethyl-benzoylamino)-1,2-dihydro-indol-3-ylidenemethyl]-1H-pyrrole-3-carboxylic acid (2-diethylamino-ethyl)-amide;

N-[3-(3,5-Dimethyl-1H-pyrrol-2-ylmethylene)-2-oxo-2,3-dihydro-1H-indol-6-yl]-3-(4-methyl-imidazol-1-yl)-5-trifluoromethyl-benzamide;

3-(4-Methyl-imidazol-1-yl)-N-[2-oxo-3-(1H-pyrrol-2-ylmethylene)-2,3-dihydro-1H-indol-6-yl]-5-trifluoromethyl-benzamide;

2,4-Dimethyl-5-{6-[3-(4-methyl-imidazol-1-yl)-5-trifluoromethyl-benzoylamino]-2-oxo-1,2-dihydro-indol-3-ylidenemethyl}-1H-pyrrole-3-carboxylic acid;

3-(2,4-Dimethyl-5-{6-[3-(4-methyl-imidazol-1-yl)-5-trifluoromethyl-benzoylamino]-2-oxo-1,2-dihydro-indol-3-ylidenemethyl}-1H-pyrrol-3-yl)-propionic acid;

4-(4-Methyl-piperazin-1-ylmethyl)-N-[2-oxo-3-(1H-pyrrol-2-ylmethylene)-2,3-dihydro-1H-indol-6-yl]-benzamide;

2,4-Dimethyl-5-{6-[4-(4-methyl-piperazin-1-ylmethyl)-benzoylamino]-2-oxo-1,2-dihydro-indol-3-ylidenemethyl}-1H-pyrrole-3-carboxylic acid (2-diethylamino-ethyl)-amide;

2,4-Dimethyl-5-{6-[3-(4-methyl-imidazol-1-yl)-5-trifluoromethyl-benzoylamino]-2-oxo-1,2-dihydro-indol-3-ylidenemethyl}-1H-pyrrole-3-carboxylic acid (2-diethylamino-ethyl)-amide;

2,4-Dimethyl-5-{6-[3-(4-methyl-imidazol-1-yl)-5-trifluoromethyl-benzoylamino]-2-oxo-1,2-dihydro-indol-3-ylidenemethyl}-1H-pyrrole-3-carboxylic acid (2-dimethylamino-ethyl)-amide;

2,4-Dimethyl-5-{6-[3-(4-methyl-imidazol-1-yl)-5-trifluoromethyl-benzoylamino]-2-oxo-1,2-dihydro-indol-3-ylidenemethyl}-1H-pyrrole-3-carboxylic acid (2-pyrrolidin-1-yl-ethyl)-amide;

2,4-Dimethyl-5-{6-[4-(4-methyl-piperazin-1-ylmethyl)-benzoylamino]-2-oxo-1,2-dihydro-indol-3-ylidenemethyl}-1H-pyrrole-3-carboxylic acid (2-dimethylamino-ethyl)-amide;

2,4-Dimethyl-5-{6-[4-(4-methyl-piperazin-1-ylmethyl)-benzoylamino]-2-oxo-1,2-dihydro-indol-3-ylidenemethyl}-1H-pyrrole-3-carboxylic acid (2-pyrrolidin-1-yl-ethyl)-amide;

3-{2,4-Dimethyl-5-[6-(3-{3-[3-(4-methyl-imidazol-1-yl)-5-trifluoromethyl-benzoylamino]-phenyl}-ureido)-2-oxo-1,2-dihydro-indol-3-ylidenemethyl]-1H-pyrrol-3-yl}-propionic acid;

5-{6-[3-(3-Benzoylamino-phenyl)-ureido]-2-oxo-1,2-dihydro-indol-3-ylidenemethyl}-2,4-dimethyl-1H-pyrrole-3-carboxylic acid (2-pyrrolidin-1-yl-ethyl)-amide;

4-(4-Methyl-piperazin-1-ylmethyl)-N-(3-{3-[2-oxo-3-(1H-pyrrol-2-ylmethylene)-2,3-dihydro-1H-indol-6-yl]-ureido}-phenyl)-benzamide;

2,4-Dimethyl-5-[6-(3-{3-[4-(4-methyl-piperazin-1-ylmethyl)-benzoylamino]-phenyl}-ureido)-2-oxo-1,2-dihydro-indol-3-ylidenemethyl]-1H-pyrrole-3-carboxylic acid (2-diethylamino-ethyl)-amide;

2,4-Dimethyl-5-[6-(3-{3-[4-(4-methyl-piperazin-1-ylmethyl)-benzoylamino]-phenyl}-ureido)-2-oxo-1,2-dihydro-indol-3-ylidenemethyl]-1H-pyrrole-3-carboxylic acid (2-dimethylamino-ethyl)-amide;

2,4-Dimethyl-5-[6-(3-{3-[3-(4-methyl-imidazol-1-yl)-5-trifluoromethyl-benzoylamino]-phenyl}-ureido)-2-oxo-1,2-dihydro-indol-3-ylidenemethyl]-1H-pyrrole-3-carboxylic acid (2-diethylamino-ethyl)-amide;

2,4-Dimethyl-5-[6-(3-{3-[3-(4-methyl-imidazol-1-yl)-5-trifluoromethyl-benzoylamino]-phenyl}-ureido)-2-oxo-1,2-dihydro-indol-3-ylidenemethyl]-1H-pyrrole-3-carboxylic acid (2-dimethylamino-ethyl)-amide;

5-{6-[3-(3-Benzoylamino-phenyl)-ureido]-2-oxo-1,2-dihydro-indol-3-ylidenemethyl}-2,4-dimethyl-1H-pyrrole-3-carboxylic acid (2-diethylamino-ethyl)-amide;

2,4-Dimethyl-5-[6-(3-{3-[4-(4-methyl-piperazin-1-ylmethyl)-benzoylamino]-phenyl}-ureido)-2-oxo-1,2-dihydro-indol-3-ylidenemethyl]-1H-pyrrole-3-carboxylic acid (2-pyrrolidin-1-yl-ethyl)-amide;

3-(4-Methyl-imidazol-1-yl)-N-(4-methyl-3-{3-[2-oxo-3-(1H-pyrrol-2-ylmethylene)-2,3-dihydro-1H-indol-6-yl]-ureido}-phenyl)-5-trifluoromethyl-benzamide;

N-(4-Methyl-3-{3-[2-oxo-3-(1H-pyrrol-2-ylmethylene)-2,3-dihydro-1H-indol-6-yl]-ureido}-phenyl)-3-trifluoromethyl-benzamide;

2,4-Dimethyl-5-(6-{3-[2-methyl-5-(3-trifluoromethyl-benzoylamino)-phenyl]-ureido}-2-oxo-1,2-dihydro-indol-3-ylidenemethyl)-1H-pyrrole-3-carboxylic acid (2-pyrrolidin-1-yl-ethyl)-amide;

N-(4-Methyl-3-{3-[2-oxo-3-(1H-pyrrol-2-ylmethylene)-2,3-dihydro-1H-indol-6-yl]-ureido}-phenyl)-benzamide;

5-{6-[3-(5-Benzoylamino-2-methyl-phenyl)-ureido]-2-oxo-1,2-dihydro-indol-3-ylidenemethyl}-2,4-dimethyl-1H-pyrrole-3-carboxylic acid (2-diethylamino-ethyl)-amide;

5-{6-[3-(5-Benzoylamino-2-methyl-phenyl)-ureido]-2-oxo-1,2-dihydro-indol-3-ylidenemethyl}-2,4-dimethyl-1H-pyrrole-3-carboxylic acid (2-dimethylamino-ethyl)-amide;

5-{6-[3-(5-Benzoylamino-2-methyl-phenyl)-ureido]-2-oxo-1,2-dihydro-indol-3-ylidenemethyl}-2,4-dimethyl-1H-pyrrole-3-carboxylic acid (2-pyrrolidin-1-yl-ethyl)-amide;

N-(4-Methyl-3-{3-[2-oxo-3-(1H-pyrrol-2-ylmethylene)-2,3-dihydro-1H-indol-6-yl]-ureido}-phenyl)-4-(4-methyl-piperazin-1-yl-methyl)-benzamide;

2-Oxo-3-(1H-pyrrol-2-ylmethylene)-2,3-dihydro-1H-indole-6-carboxylic acid {3-[4-(4-methyl-piperazin-1-ylmethyl)-benzoylamino]-phenyl}-amide;

3-[4-(2-Diethylamino-ethylcarbamoyl)-3,5-dimethyl-1H-pyrrol-2-ylmethylene]-2-oxo-2,3-dihydro-1H-indole-6-carboxylic acid (3-benzoylamino-phenyl)-amide;

3-[3,5-Dimethyl-4-(2-pyrrolidin-1-yl-ethylcarbamoyl)-1H-pyrrol-2-ylmethylene]-2-oxo-2,3-dihydro-1H-indole-6-carboxylic acid (3-benzoylamino-phenyl)-amide;

2-Oxo-3-(1H-pyrrol-2-ylmethylene)-2,3-dihydro-1H-indole-6-carboxylic acid (5-benzoylamino-2-methyl-phenyl)-amide;

2-Oxo-3-(1H-pyrrol-2-ylmethylene)-2,3-dihydro-1H-indole-6-carboxylic acid {2-methyl -5-[4-(4-methyl-piperazin-1-ylmethyl)-benzoylamino]-phenyl}-amide;

3-[4-(2-Diethylamino-ethylcarbamoyl)-3,5-dimethyl-1H-pyrrol-2-ylmethylene]-2-oxo-2,3-dihydro-1H-indole-6-carboxylic acid (5-benzoylamino-2-methyl-phenyl)-amide;

3-[3,5-Dimethyl-4-(2-pyrrolidin-1-yl-ethylcarbamoyl)-1H-pyrrol-2-ylmethylene]-2-oxo-2,3-dihydro-1H-indole-6-carboxylic acid (5-benzoylamino-2-methyl-phenyl)-amide;

N-{3-[2-Oxo-3-(1H-pyrrol-2-ylmethylene)-2,3-dihydro-1H-indol-6-ylamino]-phenyl}-benzamide;

N-{3-[2-Oxo-3-(1H-pyrrol-2-ylmethylene)-2,3-dihydro-1H-indol-6-ylamino]-phenyl}-3-trifluoromethyl-benzamide;

4-(4-Methyl-piperazin-1-ylmethyl)-N-{3-[2-oxo-3-(1H-pyrrol-2-ylmethylene)-2,3-dihydro-1H-indol-6-ylamino]-phenyl}-benzamide;

N-{4-Methyl-3-[2-oxo-3-(1H-pyrrol-2-ylmethylene)-2,3-dihydro-1H-indol-6-ylamino]-phenyl}-benzamide;

N-{4-Methyl-3-[2-oxo-3-(1H-pyrrol-2-ylmethylene)-2,3-dihydro-1H-indol-6-ylamino]-phenyl}-3-trifluoromethyl-benzamide;

N-{4-Methyl-3-[2-oxo-3-(1H-pyrrol-2-ylmethylene)-2,3-dihydro-1H-indol-6-ylamino]-phenyl}-4-(4-methyl-piperazin-1-ylmethyl)-benzamide;

5-[6-(3-Benzoylamino-phenylamino)-2-oxo-1,2-dihydro-indol-3-ylidenemethyl]-2,4-dimethyl-1H-pyrrole-3-carboxylic acid (2-diethylamino-ethyl)-amide;

5-[6-(3-Benzoylamino-phenylamino)-2-oxo-1,2-dihydro-indol-3-ylidenemethyl]-2,4-dimethyl-1H-pyrrole-3-carboxylic acid (2-dimethylamino-ethyl)-amide;

5-[6-(3-Benzoylamino-phenylamino)-2-oxo-1,2-dihydro-indol-3-ylidenemethyl]-2,4-dimethyl-1H-pyrrole-3-carboxylic acid (2-pyrrolidin-1-yl-ethyl)-amide;

5-[6-(3-Benzoylamino-phenylamino)-2-oxo-1,2-dihydro-indol-3-ylidenemethyl]-2,4-dimethyl-1H-pyrrole-3-carboxylic acid (2-piperidin-1-yl-ethyl)-amide;

5-[6-(3-Benzoylamino-phenylamino)-2-oxo-1,2-dihydro-indol-3-ylidenemethyl]-2,4-dimethyl-1H-pyrrole-3-carboxylic acid (3-pyrrolidin-1-yl-propyl)-amide;

2,4-Dimethyl-5-{2-oxo-6-[3-(3-trifluoromethyl-benzoylamino)-phenylamino]-1,2-dihydro-indol-3-ylidenemethyl}-1H-pyrrole-3-carboxylic acid(2-dimethylamino-ethyl)-amide;

2,4-Dimethyl-5-{2-oxo-6-[3-(3-trifluoromethyl-benzoylamino)-phenylamino]-1,2-dihydro-indol-3-ylidenemethyl}-1H-pyrrole-3-carboxylic acid(2-diethylamino-ethyl)-amide;

2,4-Dimethyl-5-{2-oxo-6-[3-(3-trifluoromethyl-benzoylamino)-phenylamino]-1,2-dihydro-indol-3-ylidenemethyl}-1H-pyrrole-3-carboxylic acid(2-pyrrolidin-1-yl-ethyl)-amide;

2,4-Dimethyl-5-{2-oxo-6-[3-(3-trifluoromethyl-benzoylamino)-phenylamino]-1,2-dihydro-indol-3-ylidenemethyl}-1H-pyrrole-3-carboxylic acid(2-piperidin-1-yl-ethyl)-amide;

2,4-Dimethyl-5-{2-oxo-6-[3-(3-trifluoromethyl-benzoylamino)-phenylamino]-1,2-dihydro-indol-3-ylidenemethyl}-1H-pyrrole-3-carboxylic acid(3-pyrrolidin-1-yl-propyl)-amide;

5-[6-(5-Benzoylamino-2-methyl-phenylamino)-2-oxo-1,2-dihydro-indol-3-ylidenemethyl]-2,4-dimethyl-1H-pyrrole-3-carboxylic acid (2-diethylamino-ethyl)-amide;

5-[6-(5-Benzoylamino-2-methyl-phenylamino)-2-oxo-1,2-dihydro-indol-3-ylidenemethyl]-2,4-dimethyl-1H-pyrrole-3-carboxylic acid (2-pyrrolidin-1-yl-ethyl)-amide;

2,4-Dimethyl-5-{6-[2-methyl-5-(3-trifluoromethyl-benzoylamino)-phenylamino]-2-oxo-1,2-dihydro-indol-3-ylidenemethyl}-1H-pyrrole-3-carboxylic acid (2-diethylamino-ethyl)-amide;

N-{3-[2-Oxo-3-(1H-pyrrol-2-ylmethylene)-2,3-dihydro-1H-indol-7-ylamino]-phenyl}-benzamide;

5-[7-(3-Benzoylamino-phenylamino)-2-oxo-1,2-dihydro-indol-3-ylidenemethyl]-2,4-dimethyl-1H-pyrrole-3-carboxylic acid (2-diethylamino-ethyl)-amide;

5-[7-(3-Benzoylamino-phenylamino)-2-oxo-1,2-dihydro-indol-3-ylidenemethyl]-2,4-dimethyl-1H-pyrrole-3-carboxylic acid (2-pyrrolidin-1-yl-ethyl)-amide;

2,4-Dimethyl-5-(7-{3-[4-(4-methyl-piperazin-1-ylmethyl)-benzoylamino]-phenylamino}-2-oxo-1,2-dihydro-indol-3-ylidenemethyl)-1H-pyrrole-3-carboxylic acid (2-diethylamino-ethyl) -amide;

2,4-Dimethyl-5-(7-{3-[4-(4-methyl-piperazin-1-ylmethyl)-benzoylamino]-phenylamino}-2-oxo-1,2-dihydro-indol-3-ylidenemethyl)-1H-pyrrole-3-carboxylic acid (2-dimethylamino-ethyl)-amide;

2,4-Dimethyl-5-(7-{3-[4-(4-methyl-piperazin-1-ylmethyl)-benzoylamino]-phenylamino}-2-oxo-1,2-dihydro-indol-3-ylidenemethyl)-1H-pyrrole-3-carboxylic acid (2-pyrrolidin-1-yl-ethyl)-amide;

N-{4-Methyl-3-[2-oxo-3-(1H-pyrrol-2-ylmethylene)-2,3-dihydro-1H-indol-7-ylamino]-phenyl}-benzamide;

N-{4-Methyl-3-[2-oxo-3-(1H-pyrrol-2-ylmethylene)-2,3-dihydro-1H-indol-7-ylamino]-phenyl}-4-(4-methyl-piperazin-1-ylmethyl)-benzamide;

5-[7-(5-Benzoylamino-2-methyl-phenylamino)-2-oxo-1,2-dihydro-indol-3-ylidenemethyl]-2,4-dimethyl-1H-pyrrole-3-carboxylic acid (2-diethylamino-ethyl)-amide;

5-[7-(5-Benzoylamino-2-methyl-phenylamino)-2-oxo-1,2-dihydro-indol-3-ylidenemethyl]-2,4-dimethyl-1H-pyrrole-3-carboxylic acid (2-dimethylamino-ethyl)-amide;

5-[7-(5-Benzoylamino-2-methyl-phenylamino)-2-oxo-1,2-dihydro-indol-3-ylidenemethyl]-2,4-dimethyl-1H-pyrrole-3-carboxylic acid (2-pyrrolidin-1-yl-ethyl)-amide;

5-(3-Amino-phenylamino)-3-(1H-pyrrol-2-ylmethylene)-1,3-dihydro-indol-2-one;

N-{3-[2-Oxo-3-(1H-pyrrol-2-ylmethylene)-2,3-dihydro-1H-indol-5-ylamino]-phenyl}-benzamide;

N-{3-[2-Oxo-3-(1H-pyrrol-2-ylmethylene)-2,3-dihydro-1H-indol-5-ylamino]-phenyl}-3-trifluoromethyl-benzamide;

3-(4-Methyl-imidazol-1-yl)-N-{3-[2-oxo-3-(1H-pyrrol-2-ylmethylene)-2,3-dihydro-1H -indol-5-ylamino]-phenyl}-5-trifluoromethyl-benzamide;

5-[5-(3-Benzoylamino-phenylamino)-2-oxo-1,2-dihydro-indol-3-ylidenemethyl]-2,4-dimethyl-1H-pyrrole-3-carboxylic acid (2-diethylamino-ethyl)-amide;

5-[5-(3-Benzoylamino-phenylamino)-2-oxo-1,2-dihydro-indol-3-ylidenemethyl]-2,4-dimethyl-1H-pyrrole-3-carboxylic acid (2-pyrrolidin-1-yl-ethyl)-amide;

N-{4-Methyl-3-[2-oxo-3-(1H-pyrrol-2-ylmethylene)-2,3-dihydro-1H-indol-5-ylamino]-phenyl}-benzamide;

N-{4-Methyl-3-[2-oxo-3-(1H-pyrrol-2-ylmethylene)-2,3-dihydro-1H-indol-5-ylamino]-phenyl}-4(4-methyl-piperazin-1-ylmethyl)-benzamide;

5-[5-(5-Benzoylamino-2-methyl-phenylamino)-2-oxo-1,2-dihydro-indol-3-ylidenemethyl]-2,4-dimethyl-1H-pyrrole-3-carboxylic acid (2-diethylamino-ethyl)-amide;

5-[5-(5-Benzoylamino-2-methyl-phenylamino)-2-oxo-1,2-dihydro-indol-3-ylidenemethyl]-2,4-dimethyl-1H-pyrrole-3-carboxylic acid (2-pyrrolidin-1-yl-ethyl)-amide;

3-(4-Methyl-imidazol-1-yl)-N-{3-[2-oxo-3-(1H-pyrrol-2-ylmethylene)-2,3-dihydro-1H -indol-6-ylamino]-phenyl}-5-trifluoromethyl-benzamide;

3-(4-Methyl-imidazol-1-yl)-N-{3-[6-oxo-5-(1H-pyrrol-2-ylmethylene)-6,7-dihydro-5H -pyrrolo[2,3-d]pyrimidin-2-ylamino]-phenyl}-5-trifluoromethyl-benzamide;

3-(4-Ethyl-piperazin-1-yl)-N-{3-[3-(3H-imidazol-4-ylmethylene)-2-oxo-2,3-dihydro-1H -indol-6-ylamino]-phenyl}-5-trifluoromethyl-benzamide;

2,4-Dimethyl-5-(6-{3-[3-(4-methyl-imidazol-1-yl)-5-trifluoromethyl-benzoylamino]-phenylamino}-2-oxo-1,2-dihydro-indol-3-ylidenemethyl)-1H-pyrrole-3-carboxylic acid (2-diethylamino-ethyl)-amide;

2,4-Dimethyl-5-(6-{3-[3-(1-methyl-piperidin-4-yloxy)-5-trifluoromethyl-benzoylamino]-phenylamino}-2-oxo-1,2-dihydro-indol-3-ylidenemethyl)-1H-pyrrole-3-carboxylic acid;

3-(1-Methyl-piperidin-4-yloxy)-N-{3-[2-oxo-3-(1H-pyrrol-2-ylmethylene)-2,3-dihydro-1H-indol-6-ylamino]-phenyl}-5-trifluoromethyl-benzamide;

N-{3-[3-(4-Cyano-1H-pyrrol-2-ylmethylene)-2-oxo-2,3-dihydro-1H-indol-6-ylamino]-5-methoxy-phenyl}-3-(1-methyl-piperidin-4-yloxy)-5-trifluoromethyl-benzamide;

N-{3-[3-(5-Methyl-3H-imidazol-4-ylmethylene)-2-oxo-2,3-dihydro-1H-indol-6-ylamino]-phenyl}-3-(1-methyl-piperidin-4-yloxy)-5-trifluoromethyl-benzamide;

3-[4-(2-Hydroxy-ethyl)-piperazin-1-yl]-N-{3-[2-oxo-3-(1H-pyrrol-2-ylmethylene)-2,3-dihydro-1H-indol-6-ylamino]-phenyl}-5-trifluoromethyl-benzamide;

4-Morpholin-4-yl-N-{3-[2-oxo-3-(1H-pyrrol-2-ylmethylene)-2,3-dihydro-1H-indol-6-ylamino]-phenyl}-3-trifluoromethyl-benzamide;

4-(4-Ethyl-piperazin-1-ylmethyl)-N-{3-[3-(3H-imidazol-4-ylmethylene)-2-oxo-2,3-dihydro-1H-indol-6-ylamino]-phenyl}-3-trifluoromethyl-benzamide;

4-(4-Ethyl-piperazin-1-ylmethyl)-N-{3-[3-(5-methyl-3H-imidazol-4-ylmethylene)-2-oxo-2,3-dihydro-1H-indol-6-ylamino]-phenyl}-3-trifluoromethyl-benzamide;

4-(4-Ethyl-piperazin-1-ylmethyl)-N-{3-[3-(3H-imidazol-4-ylmethylene)-2-oxo-2,3-dihydro-1H-indol-6-ylamino]-phenyl}-3-trifluoromethyl-benzamide;

5-(6-{3-[4-(4-Ethyl-piperazin-1-ylmethyl)-3-trifluoromethyl-benzoylamino]-phenylamino}-2-oxo-1,2-dihydro-indol-3-ylidenemethyl)-2,4-dimethyl-1H-pyrrole-3-carboxylic acid;

4-(4-Ethyl-piperazin-1-ylmethyl)-N-{3-[3-(5-methyl-2H-pyrazol-3-ylmethylene)-2-oxo-2,3-dihydro-1H-indol-6-ylamino]-phenyl}-3-trifluoromethyl-benzamide;

4-(4-Ethyl-piperazin-t-ylmethyl)-N-{3-[3-(4-methyl-1H-imidazol-2-ylmethylene)-2-oxo-2,3-dihydro-1H-indol-6-ylamino]-phenyl}-3-trifluoromethyl-benzamide;

3-Chloro-4-(4-ethyl-piperazin-1-ylmethyl)-N-{3-[3-(3H-imidazol-4-ylmethylene)-2-oxo-2,3-dihydro-1H-indol-6-ylamino]-phenyl}-benzamide;

3-Chloro-4-(4-ethyl-piperazin-1-ylmethyl)-N-{3-[3-(5-methyl-3H-imidazol-4-ylmethylene)-2-oxo-2,3-dihydro-1H-indol-6-ylamino]-phenyl}-benzamide;

5-(6-{3-[3-Chloro-4-(4-ethyl-piperazin-1-ylmethyl)-benzoylamino]-phenylamino}-2-oxo-1,2-dihydro-indol-3-ylidenemethyl)-2,4-dimethyl-1H-pyrrole-3-carboxylic acid;

N-{3-[3-(2-Ethyl-5-methyl-3H-imidazol-4-ylmethylene)-2-oxo-2,3-dihydro-1H-indol-6-ylamino]-phenyl}-3-(4-methyl-imidazol-1-yl)-5-trifluoromethyl-benzamide;

N-{3-[3-(1H-Indol-3-ylmethylene)-2-oxo-2,3-dihydro-1H-indol-6-ylamino]-phenyl}-3-(4-methyl-imidazol-1-yl)-5-trifluoromethyl-benzamide;

N-[3-(3-Furan-3-ylmethylene-2-oxo-2,3-dihydro-1H-indol-6-ylamino)-phenyl]-3-(4-methyl-imidazol-1-yl)-5-trifluoromethyl-benzamide;

3-(4-Methyl-imidazol-1-yl)-N-{3-[3-(5-methyl-3H-imidazol-4-ylmethylene)-2-oxo-2,3-dihydro-1H-indol-6-ylamino]-phenyl}-5-trifluoromethyl-benzamide;

3-(4-Methyl-imidazol-1-yl)-N-{3-[3-(4-methyl-1H-imidazol-2-ylmethylene)-2-oxo-2,3-dihydro-1H-indol-6-ylamino]-phenyl}-5-trifluoromethyl-benzamide;

N-{3-[3-(3H-imidazol-4-ylmethylene)-2-oxo-2,3-dihydro-1H-indol-6-ylamino]-phenyl}-3-(4-methyl-imidazol-1-yl)-5-trifluoromethyl-benzamide;

2,4-Dimethyl-5-(6-{3-[3-(4-methyl-imidazol-1-yl)-5-trifluoromethyl-benzoylamino]-phenylamino}-2-oxo-1,2-dihydro-indol-3-ylidenemethyl)-1H-pyrrole-3-carboxylic acid;

N-{3-[3-(4-Cyano-1H-pyrrol-2-ylmethylene)-2-oxo-2,3-dihydro-1H-indol-6-ylamino]-phenyl}-3-(4-methyl-imidazol-1-yl)-5-trifluoromethyl-benzamide;

N-{3-[3-(1H-indol-2-ylmethylene)-2-oxo-2,3-dihydro-1H-indol-6-ylamino]-phenyl}-3-(4-methyl-imidazol-1-yl)-5-trifluoromethyl-benzamide;

N-{3-[3-(2-Ethyl-5-methyl-3H-imidazol-4-ylmethylene)-2-oxo-2,3-dihydro-1H-indol-6-ylamino]-4-methyl-phenyl}-3-(4-methyl-imidazol-1-yl)-5-trifluoromethyl-benzamide;

5-(6-{3-[3-(4-Methyl-imidazol-1-yl)-5-trifluoromethyl-benzoylamino]-phenylamino}-2-oxo-1,2-dihydro-indol-3-ylidenemethyl)-1H-pyrrole-3-carboxylic acid amide;

4-(6-{3-[3-(4-Methyl-imidazol-1-yl)-5-trifluoromethyl-benzoylamino]-phenylamino}-2-oxo-1,2-dihydro-indol-3-ylidenemethyl)-1H-pyrrole-2-carboxylic acid methyl ester;

2,4-Dimethyl-5-(6-{3-[3-(4-methyl-imidazol-1-yl)-5-trifluoromethyl-benzoylamino]-phenylamino}-2-oxo-1,2-dihydro-indol-3-ylidenemethyl)-1H-pyrrole-3-carboxylic acid (2,3-dihydroxy-propyl)-amide;

N-[3-(3-{4-[(2-Diethylamino-ethylamino)-methyl]-1H-pyrrol-2-ylmethylene}-2-oxo-2,3-dihydro-1H-indol-6-ylamino)-phenyl]-3-trifluoromethyl-benzamide;

2,4-Dimethyl-5-(6-{3-[3-(4-methyl-piperazin-1-yl)-5-trifluoromethyl-benzoylamino]-phenylamino}-2-oxo-1,2-dihydro-indol-3-ylidenemethyl)-1H-pyrrole-3-carboxylic acid;

N-{3-[3-(5-Methyl-3H-imidazol-4-ylmethylene)-2-oxo-2,3-dihydro-1H-indol-6-ylamino]-phenyl}-3-(4-methyl-piperazin-1-yl)-5-trifluoromethyl-benzamide;

3-(4-Methyl-piperazin-1-yl)-N-{3-[2-oxo-3-(1H-pyrrol-2-ylmethylene)-2,3-dihydro-1H -indol-6-ylamino]-phenyl}-5-trifluoromethyl-benzamide;

3-(4-Methyl-piperazin-1-yl)-N-(3-{2-oxo-3-[(4-sulfamoyl-phenyl)hydrazono]-2,3-dihydro-1H-indol-6-ylamino}-phenyl)-5-trifluoromethyl-benzamide;

N-{3-[3-(4-Cyano-1H-pyrrol-2-ylmethylene)-2-oxo-2,3-dihydro-1H-indol-6-ylamino]-phenyl}-3-(4-methyl-piperidin-1-yl)-5-trifluoromethyl-benzamide;

N-{3-Methoxy-5-[2-oxo-3-(1H-pyrrol-2-ylmethylene)-2,3-dihydro-1H-indol-6-ylamino]-phenyl}-3-(4-methyl-piperazin-1-yl)-5-trifluoromethyl-benzamide;

5-(6-{3-[3-(4-Methyl-piperazin-1-yl)-5-trifluoromethyl-benzoylamino]-phenylamino}-2-oxo-1,2-dihydro-indol-3-ylidenemethyl)-1H-pyrrole-3-carboxylic acid amide;

N-{3-[3-(4-Cyano-1H-pyrrol-2-ylmethylene)-2-oxo-2,3-dihydro-1H-indol-6-ylamino]-5-methoxy-phenyl}-3-(4-methyl-piperazin-1-yl)-5-trifluoromethyl-benzamide;

N-{4-Methyl-3-[2-oxo-3-(1H-pyrrol-2-ylmethylene)-2,3-dihydro-1H-indol-6-ylamino]-phenyl}-3-(4-Methyl-piperazin-1-yl)-5-trifluoromethyl-benzamide;

N-{3-[3-(4-Cyano-1H-pyrrol-2-ylmethylene)-2-oxo-2,3-dihydro-1H-indol-6-ylamino]-phenyl}-3-(4-hydroxy-piperidin-1-yl)-5-trifluoromethyl-benzamide;

3-(4-Hydroxy-piperidin-1-yl)-N-{3-[2-oxo-3-(1H-pyrrol-2-ylmethylene)-2,3-dihydro-1H -indol-6-ylamino]-phenyl}-5-trifluoromethyl-benzamide;

5-(6-{3-[4-(4-Methyl-piperazin-1-yl)-3-trifluoromethyl-benzoylamino]-phenylamino}-2-oxo-1,2-dihydro-indol-3-ylidenemethyl)-1H-pyrrole-3-carboxylic acid amide;

3-Methyl-N-{3-[3-(5-methyl-3H-imidazol-4-ylmethylene)-2-oxo-2,3-dihydro-1H-indol-6-ylamino]-phenyl}-benzamide;

N-{3-[3-(5-Methyl-3H-imidazol-4-ylmethylene)-2-oxo-2,3-dihydro-1H-indol-6-ylamino]-phenyl}-3-trifluoromethyl-benzamide;

N-{3-[3-(4-Cyano-1H-pyrrol-2-ylmethylene)-2-oxo-2,3-dihydro-1H-indol-6-ylamino]-4-methyl-phenyl}-3-(4-methyl-piperazin-1-yl)-5-trifluoromethyl-benzamide;

5-{6-[3-(3-Methyl-benzoylamino)-phenylamino]-2-oxo-1,2-dihydro-indol-3-ylidenemethyl}-1H-pyrrole-3-carboxylic acid amide;

2,4-Dimethyl-5-(6-{3-[3-(4-methyl-piperazin-1-yl)-5-trifluoromethyl-benzoylamino]-phenylamino}-2-oxo-1,2-dihydro-indol-3-ylidenemethyl)-1H-pyrrole-3-carboxylic acid (3-dimethylamino-propyl)-amide;

2,4-Dimethyl-5-{2-oxo-6-[3-(3-trifluoromethyl-benzoylamino)-phenoxy]-1,2-dihydro -indol-3-ylidenemethyl}-1H-pyrrole-3-carboxylic acid (2-dimethylamino-ethyl)-methyl-amide;

N-(3-{3-[3,5-Dimethyl-4-(4-methyl-piperazine-1-carbonyl)-1H-pyrrol-2-ylmethylene]-2-oxo-2,3-dihydro-1H-indol-6-yloxy}-phenyl)-3-trifluoromethyl-benzamide;

2,4-Dimethyl-5-{2-oxo-6-[3-(3-trifluoromethyl-benzoylamino)-phenoxy]-1,2-dihydro -indol-3-ylidenemethyl}-1H-pyrrole-3-carboxylic acid (3-dimethylamino-propyl)-amide;

2,4-Dimethyl-5-{2-oxo-6-[3-(3-trifluoromethyl-benzoylamino)-phenoxy]-1,2-dihydro -indol-3-ylidenemethyl}-1H-pyrrole-3-carboxylic acid (3-pyrrolidin-1-yl-propyl)-amide;

2,4-Dimethyl-5-{2-oxo-6-[3-(3-trifluoromethyl-benzoylamino)-phenoxy]-1,2-dihydro -indol-3-ylidenemethyl}1H-pyrrole-3-carboxylic acid methyl-(3-methylamino-propyl)-amide;

2,4-Dimethyl-5-{2-oxo-6-[3-(3-trifluoromethyl-benzoylamino)-phenoxy]-1,2-dihydro -indol-3-ylidenemethyl}-1H-pyrrole-3-carboxylic acid (2-morpholin-4-yl-ethyl)-amide;

N-(3-{3-[4-(3-Dimethylamino-pyrrolidine-1-carbonyl)-3,5-dimethyl-1H-pyrrol-2-ylmethylene]-2-oxo-2,3-dihydro-1H-indol-6-yloxy}-phenyl)-3-trifluoromethyl-benzamide;

N-[3-(3-{4-[4-(2-Diethylamino-ethyl)-piperazine-1-carbonyl]-3,5-dimethyl-1H-pyrrol-2-ylmethylene}-2-oxo-2,3-dihydro-1H-indol-6-yloxy)-phenyl]-3-trifluoromethyl-benzamide;

5-{2-Oxo-6-[3-(3-trifluoromethyl-benzoylamino)-phenoxy]-1,2-dihydro-indol-3-ylidenemethyl}-1H-pyrrole-3-carboxylic acid methyl-(3-methylamino-propyl)-amide;

2,4-Dimethyl-5-{2-oxo-6-[3-(3-trifluoromethyl-benzoylamino)-phenoxy]-1,2-dihydro -indol-3-ylidenemethyl}-1H-pyrrole-3-carboxylic acid ethoxy-amide;

2,4-Dimethyl-5-{2-Oxo-6-[3-(3-trifluoromethyl-benzoylamino)-phenoxy]-1,2-dihydro -indol-3-ylidenemethyl}-1H-pyrrole-3-carboxylic acid (4-methyl-piperazin 1-yl)-amide;

5-{2-Oxo-6-[3-trifluoromethyl-benzoylamino)-phenoxy]-1,2-dihydro-indol-3-ylidenemethyl}-1H-pyrrole-3-carboxylic acid;

5-{2-Oxo-6-[3-(3-trifluoromethyl-benzoylamino)-phenoxy]-1,2-dihydro-indol-3-ylidenemethyl}-1H-pyrrole-3-carboxylic acid (3-dimethylamino-propyl)-amide;

N-(3-{3-[4-(4-Methyl-piperazine-1-carbonyl)-1H-pyrrol-2-ylmethylene]-2-oxo-2,3-dihydro-1H-indol-6-yloxy}-phenyl)-3-trifluoromethyl-benzamide;

5-{2-Oxo-6-[3-(3-trifluoromethyl-benzoylamino)-phenoxy]-1,2-dihydro-indol-3-ylidenemethyl}-1H-pyrrole-3-carboxylic acid (2-dimethylamino-ethyl)-methyl-amide;

N-[3-(3-{4-[4-(2-Diethylamino-ethyl)-piperazine-1-carbonyl]-1H-pyrrol-2-ylmethylene}-2-oxo-2,3-dihydro-1H-indol-6-yloxy)-phenyl]-3-trifluoromethyl-benzamide;

2,4-Dimethyl-5-{6-[3-(3-methyl-benzoylamino)-phenoxy]-2-oxo-1,2-dihydro-indol-3-ylidenemethyl}-1H-pyrrole-3-carboxylic acid;

N-(3-{3-[3,5-Dimethyl-4-(4-methyl-piperazine-1-carbonyl)-1H-pyrrol-2-ylmethylene]-2-oxo-2,3-dihydro-1H-indol-6-yloxy}-phenyl)-3-methyl-benzamide;

2,4-Dimethyl-5-{6-[3-(3-methyl-benzoylamino)-phenoxy]-2-oxo-1,2-dihydro-indol-3-ylidenemethyl}-1H-pyrrole-3-carboxylic acid (2-morpholin-4-yl-ethyl)-amide;

5-{6-[3-(3-Methyl-benzoylamino)-phenoxy]-2-oxo-1,2-dihydro-indol-3-ylidenemethyl}-1H-pyrrole-3-carboxylic acid (3-pyrrolidin-1-yl-propyl)-amide;

5-{6-[3-(3-Methyl-benzoylamino)-phenoxy]-2-oxo-1,2-dihydro-indol-3-ylidenemethyl}-1H-pyrrole-3-carboxylic acid;

5-{6-[3-(3-Methyl-benzoylamino)-phenoxy]-2-oxo-1,2-dihydro-indol-3-ylidenemethyl}-1H-pyrrole-3-carboxylic acid (3-dimethylamino-propyl)-amide;

5-{6-[3-(3-Methyl-benzoylamino)-phenoxy]-2-oxo-1,2-dihydro-indol-3-ylidenemethyl}-1H-pyrrole-3-carboxylic acid (2-morpholin-4-yl-ethyl)-amide;

5-{6-[3-(3-Methyl-benzoylamino)-phenoxy]-2-oxo-1,2-dihydro-indol-3-ylidenemethyl}-1H-pyrrole-3-carboxylic acid (2-dimethylamino-ethyl)-methyl-amide;

3-Methyl-N-(3-{3-[4-(4-methyl-piperazine-1-carbonyl)-1H-pyrrol-2-ylmethylene]-2-oxo-2,3-dihydro-1H-indol-6-yloxy}-phenyl)-benzamide;

5-{6-[3-(3-Methyl-benzoylamino)-phenoxy]-2-oxo-1,2-dihydro-indol-3-ylidenemethyl}-1H-pyrrole-3-carboxylic acid (4-methyl-piperazin-1-yl)-amide;

N-[3-(3-{4-[4-(2-Diethylamino-ethyl)-piperazine-1-carbonyl]-1H-pyrrol-2-ylmethylene}-2-oxo-2,3-dihydro-1H-indol-6-yloxy)-phenyl]-3-methyl-benzamide;

N-(3-{3-[3,5-Dimethyl-4-(4-pyrimidin-2-yl-piperazine-1-carbonyl)-1H-pyrrol-2-ylmethylene]-2-oxo-2,3-dihydro-1H-indol-6-yloxy}-phenyl)-3-trifluoromethyl-benzamide;

N-(3-{3-[3,5-Dimethyl-4-(2,3,5,6-tetrahydro-[1,2′]bipyrazinyl-4-carbonyl)-1H-pyrrol-2-ylmethylene]-2-oxo-2,3-dihydro-1H-indol-6-yloxy}-phenyl)-3-trifluoromethyl-benzamide;

2,4-Dimethyl-5-{6-[3-(3-methyl-benzoylamino)-phenoxy]-2-oxo-1,2-dihydro-indol-3-ylidenemethyl}-1H-pyrrole-3-carboxylic acid (2-dimethylamino-ethyl)-methyl-amide;

N-[4-(4-Methyl-piperazin-1-ylmethyl)-3-trifluoromethyl-phenyl]-3-[2-oxo-3-(1H-pyrrol-2-ylmethylene)-2,3-dihydro-1H-pyrrolo[2,3-b]pyridin-6-ylamino]benzamide;

4-Trifluoromethyl-1H-indole-6-carboxylic acid {3-methoxy-5-[2-oxo-3-(1H-pyrrol-2-ylmethylene)-2,3-dihydro-1H-indol-6-ylamino]-phenyl}-amide;

N-[3-(3-Benzyloxyimino-2-oxo-2,3-dihydro-1H-indol-6-ylamino)-phenyl]-3-(4-methyl -piperazin-1-yl)-5-trifluoromethyl-benzamide;

3-[2-Oxo-3-(1H-pyrrol-2-ylmethylene)-2,3-dihydro-1H-pyrrolo[2,3-b]pyridin-6-yloxy]-N-(3-trifluoromethyl-phenyl)-benzamide;

5-(6-Benzoylamino-2-oxo-1,2-dihydro-indol-3-ylidenemethyl)-2,4-dimethyl-1H-pyrrole-3-carboxylic acid (2-dimethylamino-ethyl)-amide; and

3-(1H-Pyrrol-2-ylmethylene)-6-{3-[3-(3-trifluoromethyl-phenyl)-[1,2,4]oxadiazol-5-yl]-phenylamino}-1,3-dihydro-indol-2-one;

or the pharmaceutical acceptable salts thereof.

8. A pharmaceutical composition comprising a therapeutically effective amount of a compound of claim 1 in combination with a pharmaceutically acceptable excipient.

9. A compound selected from the group consisting of: