T cell inhibitory receptor compositions and uses thereof
The invention relates to compositions which bind T cell inhibitory receptor molecules and modulate T cell activity, and methods of using such compositions. Such compositions include biliary glycoprotein binding agents. Methods for modulating killer T cell activities, including cytotoxicity and proliferation also are provided.
1. A method for the treatment of an autoimmune disease or transplant rejection comprising administering to a subject in need of such treatment an antibody or an antigen-binding fragment thereof, wherein said antibody or antigen-binding fragment thereof binds two or more biliary glycoprotein polypeptides.
2. The method of claim 1 , wherein the antigen-binding fragment is a F(ab) 2 fragment.
3. The method of claim 1 , wherein the antibody is a monoclonal antibody or an antigen-binding fragment thereof.