Polypeptides from non-typeable
Polypeptides comprising non-typeable Haemophilus influenzae (NTHi) amino acid sequences. Over 2500 specific NTHi proteins are disclosed. The invention also provides related polypeptides, nucleic acids, antibodies and methods. These can all be used in medicine for treating or preventing disease and/or infection caused by H. influenzae , such as otitis media.
1. An isolated, immunogenic polypeptide comprising an amino acid sequence with at least 98% sequence identity to the sequence of SEQ ID NO:3310.
2. The polypeptide of claim 1 , wherein said polypeptide comprises the amino acid sequence of SEQ ID NO:3310.
3. A composition comprising: (a) the polypeptide of claim 2 ; and (b) a pharmaceutically acceptable carrier.
4. The composition of claim 3 , further comprising an adjuvant.
5. A composition comprising: (a) the polypeptide of claim 1 ; and (b) a pharmaceutically acceptable carrier.
6. The composition of claim 5 , further comprising an adjuvant.