Amphiphilic block copolymers and nano particles comprising the same
An amphiphilic block copolymer. The amphiphilic block copolymer includes one or more hydrophilic polymers, one or more hydrophobic polymer, and one or more zwitterions. The invention also provides a nano particle and carrier comprising the amhpiphilic block copolymer for delivery of water-insoluble drugs, growth factors, genes, or cosmetic substances.
1. A block copolymer comprising: a hydrophobic block, a hydrophilic block bonded to the hydrophobic block, and only one zwitterion, wherein the zwitterion, having one positive charge and one negative charge, is bonded to a terminal end of the hydrophobic block; the hydrophobic block is polycaprolactone (PCL), polyvalerolactone (PVL), poly(lactide-co-glycolide) (PLGA), polylactic acid (PLA), polybutyrolactone (PBL), polyglycolide, or polypropiolactone (PPL); and the hydrophilic block is polyethylene glycol (PEG), hyaluronic acid (HA) or poly-γ-glutamic acid (PGA).
2. The block copolymer as claimed in claim 1 , wherein the hydrophobic block has a molecular weight of about 1000-30000.
3. The block copolymer as claimed in claim 1 , wherein the zwitterion comprises phosphorylcholine (PC), sulfobetaine (NS), or an amino acid.
4. The block copolymer as claimed in claim 1 , wherein the hydrophilic block has a molecular weight of about 550-20000.
5. The block copolymer as claimed in claim 1 , wherein the copolymer is bio-degradable.
6. The block copolymer as claimed in claim 1 , wherein the copolymer is bio-compatible.
7. A nano particle comprising one or more block copolymers as claimed in claim 1 .
8. The nano particle as claimed in claim 7 , wherein the nano particle has a hydrophobic interior and hydrophilic surface.
9. The nano particle as claimed in claim 7 , wherein the nano particle has a diameter of about 20-1000 nm.
10. A nano carrier, comprising:
a nano particle as claimed in claim 7 ; and
an active substance encapsulated inside the particle.
11. The nano carrier as claimed in claim 10 , wherein the active substance comprises water-insoluble drugs, growth factors, genes, or water-insoluble cosmetic substances.
12. The nano carrier as claimed in claim 10 , wherein the active substance comprises camptothecin or derivatives thereof.
13. The nano carrier as claimed in claim 10 , wherein the active substance comprises water-insoluble ingredients for skincare.
14. The nano carrier as claimed in claim 10 , wherein the nano carrier is delivered by oral, transdermal administration, injection, or inhalation.
15. The block copolymer as claimed in claim 1 , wherein the hydrophobic block is polycaprolactone (PCL), the hydrophilic block is polyethylene glycol (PEG), and the zwitterion is phosphorylcholine (PC), sulfobetaine (NS), or benzyl histidine.
16. The block copolymer as claimed in claim 15 , wherein when the zwitterion is PC, the hydrophilic block has a molecular weight of 5000 and the hydrophobic block has a molecular weight of 1100-1900.
17. The block copolymer as claimed in claim 15 , wherein when the zwitterion is NS, the hydrophilic block has a molecular weight of 2000-5000 and the hydrophobic block has a molecular weight of 1000-3700.
18. The block copolymer as claimed in claim 1 , wherein the hydrophobic block is polycaprolactone, the hydrophilic block is polyethylene glycol, and the zwitterion is phosphorylcholine.
19. The block copolymer as claimed in claim 1 , wherein the hydrophobic block is polylactic acid, the hydrophilic block is polyethylene glycol, and the zwitterion is phosphorylcholine.