Methods and compositions for modulation of blood-neural barrier
Methods and compositions for modulating blood-neural barrier (BNB) for the treatment of CNS conditions such as edema, and for increased drug delivery efficacy across the BNB. The present invention further relates to improved tPA treatment of ischemic cerebrovascular and related diseases in combination with antagonism of the PDGF signaling pathway. The inventive method and composition is particularly suitable for conjunctive therapy of ischemic stroke using tPA and an anti-PDGF-C antagonist or an anti-PDGFR-α antagonist.
1. A method for treating edema caused by increased permeability of the blood-neural barrier in a higher vertebrate animal suffering from said edema, comprising administering to said animal an effective amount of a platelet derived growth factor receptor-α (PDGFR-α) antagonist, wherein said PDGFR-α antagonist is an anti-PDGFR-α antibody.
2. The method according to claim 1 , wherein the animal is a mammal.
3. The method according to claim 2 , wherein the animal is a human.
4. The method according to claim 3 , wherein the human suffers from edema ascites, cerebral edema, hydrocephalus, glaucoma, a retinopathy, or a maculopathy.
5. The method according to claim 4 , wherein the retinopathy is diabetic retinopathy, or the maculopathy is wet age-related macular degeneration (AMD).