Podophyllotoxin derivatives
View Patent ↗4-O esters of podophyllotoxin and 4′-demethylepipodophyllotoxin are provided. The compounds are 4-O esters of an alkanoic acid or substituted alkanoic acid and podophyllotoxin and 4′-demethylepipodophyllotoxin. The compounds are useful for treating cancer.
1. A compound selected from the group consisting of
podophyllotoxin-4-O-ester of 4-fluorophenoxyacetic acid;
podophyllotoxin-4-O-ester of 4-bromophenoxyacetic acid;
podophyllotoxin-4-O-ester of 4-iodophenoxyacetic acid;
podophyllotoxin-4-O-ester of 3-chlorophenoxyacetic acid;
podophyllotoxin-4-O-ester of 4-chloro-2-methylphenoxyacetic acid;
podophyllotoxin-4-O-ester of 4-formylphenoxyacetic acid;
podophyllotoxin-4-O-ester of 4-methoxyphenoxyacetic acid;
podophyllotoxin-4-O-ester of 2,4-dichlorophenoxyacetic acid;
podophyllotoxin-4-O-ester of 7-(carboxymethoxy)-3-chloro-4-methylcoumarin;
podophyllotoxin-4-O-ester of 4-(4-dichloroethylamino)phenylbutyric acid;
podophyllotoxin-4-O-ester of (+)-menthoxyethanoic acid;
podophyllotoxin-4-O-ester of 2-(((2,4,5,7-tetranitro-9H-fluoren-9-ylidene)amino)oxy)propionic acid; and
podophyllotoxin-4-O-ester of N—BOC-erythro-D-β-methylphenylalanine.
2. The compound of claim 1 in combination with a pharmaceutically acceptable excipient to form a pharmaceutical composition.