Compositions and methods for the treatment of respiratory disorders
Methods and compositions are provided for the treatment of acute lung injury and pulmonary fibrosis by administering inhibitors of IGF-1R signaling activity.
1. A method for the treatment of acute lung injury in an individual in need thereof, the method comprising administering an inhibitor of IGF-1R signaling activity to said individual, wherein said inhibitor comprises an antibody or antigen-binding fragment thereof that binds the IGF-1R.
2. The method of claim 1 wherein said antibody or antigen-binding fragment thereof binds to the external domain of IGF-1R and inhibits binding of IGF-I or IGF-II to IGF-1R.
3. The method of claim 1 wherein said antibody or antigen-binding fragment thereof neutralizes IGF-1R signaling activity.
4. The method of claim 1 wherein said antibody or antigen-binding fragment thereof down-modulates IGF-1R.
5. The method of claim 1 wherein said antibody or antigen-binding fragment thereof comprises an antigen-binding domain of the antibody IMC-A12.
6. The method of claim 1 wherein said antibody or antigen-binding fragment thereof binds an epitope that is bound by the antibody IMC-A12.
7. The method of claim 1 wherein said inhibitor of IGF-1R activity is administered systemically.
8. The method of claim 1 wherein said inhibitor of IGF-1R signaling activity is delivered to the lung as an aerosol.