cMET inhibitors

1. A compound having the formula:

or a pharmaceutically acceptable salt thereof, wherein

G is selected from the group consisting of CR 4 and N;

J is selected from the group consisting of CR 5 and N;

K is selected from the group consisting of CR 6 and N;

M is selected from the group consisting of CR 7 and N;

L is absent or a linker providing 1,2,3,4,5 or 6 atom separation between the rings to which L is attached, wherein the atoms of the linker providing the separation are selected from the group consisting of carbon, oxygen, nitrogen, and sulfur;

T is selected from the group consisting of CR 8 and N;

U is selected from the group consisting of CR 9 and N;

V is selected from the group consisting of CR 10 and N;

W is selected from the group consisting of CR 11 and N;

X is selected from the group consisting of CR 12 and N;

Y is selected from the group consisting of CR 13 and N;

Z is selected from the group consisting of CR 14 R 15 and NR 16 ;

R 1 is selected from the group consisting of hydrogen, (C 1-10 )alkoxy, (C 4-12 )aryloxy, hetero(C 1-10 )aryloxy, aminocarbonyl, (C 1-10 )alkylcarbonyl, (C 3-12 )cycloalkyl(C 1-5 )carbonyl, hetero(C 3-12 )cycloalkyl(C 1-10 )carbonyl, aryl(C 1-10 )carbonyl, hetero(C 1-10 )aryl(C 1-5 )carbonyl, (C 9-12 )bicycloaryl(C 1-5 )carbonyl, hetero(C 8-12 )bicycloaryl(C 1-5 )carbonyl, amino, (C 1-10 )alkylamino, (C 1-10 )alkyl, halo(C 1-10 )alkyl, hydroxy(C 1-10 )alkyl, aza(C 1-10 )alkyl, (C 1-10 )oxaalkyl, (C 1-10 )oxoalkyl, (C 3-12 )cycloalkyl(C 1-5 )alkyl, hetero(C 3-12 )cycloalkyl(C 1-10 )alkyl, aryl(C 1-10 )alkyl, hetero(C 1-10 )aryl(C 1-5 )alkyl, (C 9-12 )bicycloaryl(C 1-5 )alkyl, hetero(C 8-12 )bicycloaryl(C 1-5 )alkyl, hetero(C 1-10 )alkyl, (C 3-12 )cycloalkyl, hetero(C 3-12 )cycloalkyl, (C 9-12 )bicycloalkyl, hetero(C 3-12 )bicycloalkyl, (C 4-12 )aryl, hetero(C 4-10 )aryl, (C 9-12 )bicycloaryl and hetero(C 4-12 )bicycloaryl, each substituted or unsubstituted, or R 1 has the formula

R 2 is hydrogen or a substituent convertible in vivo to hydrogen;

R 3 is selected from the group consisting of hydrogen, (C 1-10 )alkoxy, (C 4-12 )aryloxy, hetero(C 1-10 )aryloxy, aminocarbonyl, amino, (C 1-10 )alkylamino, (C 1-10 )alkyl, halo(C 1-10 )alkyl, hydroxy(C 1-10 )alkyl, aza(C 1-10 )alkyl, (C 1-10 )oxaalkyl, (C 1-10 )oxoalkyl, (C 3-12 )cycloalkyl(C 1-5 )alkyl, hetero(C 3-12 )cycloalkyl(C 1-10 )alkyl, aryl(C 1-10 )alkyl, hetero(C 1-10 )aryl(C 1-5 )alkyl, (C 9-12 )bicycloaryl(C 1-5 )alkyl, hetero(C 8-12 )bicycloaryl(C 1-5 )alkyl, hetero(C 1-10 )alkyl, (C 3-12 )cycloalkyl, hetero(C 3-12 )cycloalkyl, (C 9-12 )bicycloalkyl, hetero(C 3-12 )bicycloalkyl, (C 4-12 )aryl, hetero(C 4-10 )aryl, (C 9-12 )bicycloaryl and hetero(C 4-12 )bicycloaryl, each substituted or unsubstituted, or R 3 is absent when the nitrogen to which it is bound forms part of a double bond;

R 4 is selected from the group consisting of hydrogen, halo, nitro, cyano, hydroxy, (C 1-10 )alkoxy, (C 4-12 )aryloxy, hetero(C 1-10 )aryloxy, aminocarbonyl, amino, (C 1-10 )alkylamino, (C 1-10 )alkyl, halo(C 1-10 )alkyl, hydroxy(C 1-10 )alkyl, aza(C 1-10 )alkyl, (C 1-10 )oxaalkyl, (C 1-10 )oxoalkyl, (C 3-12 )cycloalkyl(C 1-5 )alkyl, hetero(C 3-12 )cycloalkyl(C 1-10 )alkyl, aryl(C 1-10 )alkyl, hetero(C 1-10 )aryl(C 1-5 )alkyl, (C 9-12 )bicycloaryl(C 1-5 )alkyl, hetero(C 8-12 )bicycloaryl(C 1-5 )alkyl, hetero(C 1-10 )alkyl, (C 3-12 )cycloalkyl, hetero(C 3-12 )cycloalkyl, (C 9-12 )bicycloalkyl, hetero(C 3-12 )bicycloalkyl, (C 4-12 )aryl, hetero(C 4-10 )aryl, (C 9-12 )bicycloaryl and hetero(C 4-12 )bicycloaryl, each substituted or unsubstituted;

R 5 is selected from the group consisting of hydrogen, halo, nitro, cyano, hydroxy, (C 1-10 )alkoxy, (C 4-12 )aryloxy, hetero(C 1-10 )aryloxy, aminocarbonyl, amino, (C 1-10 )alkylamino, (C 1-10 )alkyl, halo(C 1-10 )alkyl, hydroxy(C 1-10 )alkyl, aza(C 1-10 )alkyl, (C 1-10 )oxaalkyl, (C 1-10 )oxoalkyl, (C 3-12 )cycloalkyl(C 1-5 )alkyl, hetero(C 3-12 )cycloalkyl(C 1-10 )alkyl, aryl(C 1-10 )alkyl, hetero(C 1-10 )aryl(C 1-5 )alkyl, (C 9-12 )bicycloaryl(C 1-5 )alkyl, hetero(C 8-12 )bicycloaryl(C 1-5 )alkyl, hetero(C 1-10 )alkyl, (C 3-12 )cycloalkyl, hetero(C 3-12 )cycloalkyl, (C 9-12 )bicycloalkyl, hetero(C 3-12 )bicycloalkyl, (C 4-12 )aryl, hetero(C 4-10 )aryl, (C 9-12 )bicycloaryl and hetero(C 4-12 )bicycloaryl, each substituted or unsubstituted;

R 6 is selected from the group consisting of hydrogen, halo, nitro, cyano, hydroxy, (C 1-10 )alkoxy, (C 4-12 )aryloxy, hetero(C 1-10 )aryloxy, aminocarbonyl, amino, (C 1-10 )alkylamino, (C 1-10 )alkyl, halo(C 1-10 )alkyl, hydroxy(C 1-10 )alkyl, aza(C 1-10 )alkyl, (C 1-10 )oxaalkyl, (C 1-10 )oxoalkyl, (C 3-12 )cycloalkyl(C 1-5 )alkyl, hetero(C 3-12 )cycloalkyl(C 1-10 )alkyl, aryl(C 1-10 )alkyl, hetero(C 1-10 )aryl(C 1-5 )alkyl, (C 9-12 )bicycloaryl(C 1-5 )alkyl, hetero(C 8-12 )bicycloaryl(C 1-5 )alkyl, hetero(C 1-10 )alkyl, (C 3-12 )cycloalkyl, hetero(C 3-12 )cycloalkyl, (C 9-12 )bicycloalkyl, hetero(C 3-12 )bicycloalkyl, (C 4-12 )aryl, hetero(C 4-10 )aryl, (C 9-12 )bicycloaryl and hetero(C 4-12 )bicyoloaryl, each substituted or unsubstituted;

R 7 is selected from the group consisting of hydrogen, halo, nitro, cyano, hydroxy, (C 1-10 )alkoxy, (C 4-12 )aryloxy, hetero(C 1-10 )aryloxy, aminocarbonyl, amino, (C 1-10 )alkylamino, (C 1-10 )alkyl, halo(C 1-10 )alkyl, hydroxy(C 1-10 )alkyl, aza(C 1-10 )alkyl, (C 1-10 )oxaalkyl, (C 1-10 )oxoalkyl, (C 3-12 )cycloalkyl(C 1-5 )alkyl, hetero(C 3-12 )cycloalkyl(C 1-10 )alkyl, aryl(C 1-10 )alkyl, hetero(C 1-10 )aryl(C 1-5 )alkyl, (C 9-12 )bicycloaryl(C 1-5 )alkyl, hetero(C 8-12 )bicycloaryl(C 1-5 )alkyl, hetero(C 1-10 )alkyl, (C 3-12 )cycloalkyl, hetero(C 3-12 )cycloalkyl, (C 9-12 )bicycloalkyl, hetero(C 3-12 )bicycloalkyl, (C 4-12 )aryl, hetero(C 4-10 )aryl, (C 9-12 )bicycloaryl and hetero(C 4-12 )bicyoloaryl, each substituted or unsubstituted;

R 8 is selected from the group consisting of hydrogen, halo, nitro, cyano, hydroxy, (C 1-10 )alkoxy, (C 4-12 )aryloxy, hetero(C 1-10 )aryloxy, aminocarbonyl, amino, (C 1-10 )alkylamino, (C 1-10 )alkyl, halo(C 1-10 )alkyl, hydroxy(C 1-10 )alkyl, aza(C 1-10 )alkyl, (C 1-10 )oxaalkyl, (C 1-10 )oxoalkyl, (C 3-12 )cycloalkyl(C 1-5 )alkyl, hetero(C 3-12 )cycloalkyl(C 1-10 )alkyl, aryl(C 1-10 )alkyl, hetero(C 1-10 )aryl(C 1-5 )alkyl, (C 9-12 )bicyoloaryl(C 1-5 )alkyl, hetero(C 8-12 )bicycloaryl(C 1-5 )alkyl, hetero(C 1-10 )alkyl, (C 3-12 )cycloalkyl, hetero(C 3-12 )cycloalkyl, (C 9-12 )bicycloalkyl, hetero(C 3-12 )bicycloalkyl, (C 4-12 )aryl, hetero(C 4-10 )aryl, (C 9-12 )bicycloaryl and hetero(C 4-12 )bicycloaryl, each substituted or unsubstituted;

R 9 is selected from the group consisting of hydrogen, halo, nitro, cyano, hydroxy, (C 1-10 )alkoxy, (C 4-12 )aryloxy, hetero(C 1-10 )aryloxy, aminocarbonyl, amino, (C 1-10 )alkylamino, amido, (C 1-10 )alkyl, halo(C 1-10 )alkyl, hydroxy(C 1-10 )alkyl, amino(C 1-10 )alkyl, amido(C 1-10 )alkylamino(C 1-10 )alkyl, sulfonyl(C 1-10 )alkyl, sulfinyl(C 1-10 )alkyl, aza(C 1-10 )alkyl, (C 1-10 )oxaalkyl, (C 1-10 )oxoalkyl, (C 3-12 )cycloalkyl(C 1-5 )alkyl, hetero(C 3-12 )cycloalkyl(C 1-10 )alkyl, aryl(C 1-10 )alkyl, hetero(C 1-10 )aryl(C 1-5 )alkyl, (C 9-12 )bicycloaryl(C 1-5 )alkyl, hetero(C 8-12 )bicycloaryl(C 1-5 )alkyl, hetero(C 1-10 )alkyl, (C 3-12 )cycloalkyl, hetero(C 3-12 )cycloalkyl, (C 9-12 )bicycloalkyl, hetero(C 3-12 )bicycloalkyl, (C 4-12 )aryl, hetero(C 4-10 )aryl, (C 9-12 )bicycloaryl and hetero(C 4-12 )bicycloaryl, each substituted or unsubstituted;

R 10 is selected from the group consisting of hydrogen, halo, nitro, cyano, hydroxy, (C 1-10 )alkoxy, (C 4-12 )aryloxy, hetero(C 1-10 )aryloxy, aminocarbonyl, amino, (C 1-10 )alkylamino, amido, (C 1-10 )alkyl, halo(C 1-10 )alkyl, hydroxy(C 1-10 )alkyl, amino(C 1-10 )alkyl, amido(C 1-10 )alkylamino(C 1-10 )alkyl, sulfonyl(C 1-10 )alkyl, sulfinyl(C 1-10 )alkyl, aza(C 1-10 )alkyl, (C 1-10 )oxaalkyl, (C 1-10 )oxoalkyl, (C 3-12 )cycloalkyl(C 1-5 )alkyl, hetero(C 3-12 )cycloalkyl(C 1-10 )alkyl, aryl(C 1-10 )alkyl, hetero(C 1-10 )aryl(C 1-5 )alkyl, (C 9-12 )bicycloaryl(C 1-5 )alkyl, hetero(C 8-12 )bicycloaryl(C 1-5 )alkyl, hetero(C 1-10 )alkyl, (C 3-12 )cycloalkyl, hetero(C 3-12 )cycloalkyl, (C 9-12 )bicycloalkyl, hetero(C 3-12 )bicycloalkyl, (C 4-12 )aryl, hetero(C 4-10 )aryl, (C 9-12 )bicycloaryl and hetero(C 4-12 )bicycloaryl, each substituted or unsubstituted;

R 11 is selected from the group consisting of hydrogen, halo, nitro, cyano, hydroxy, (C 1-10 )alkoxy, (C 4-12 )aryloxy, hetero(C 1-10 )aryloxy, aminocarbonyl, amino, (C 1-10 )alkylamino, (C 1-10 )alkyl, halo(C 1-10 )alkyl, hydroxy(C 1-10 )alkyl, aza(C 1-10 )alkyl, (C 1-10 )oxaalkyl, (C 1-10 )oxoalkyl, (C 3-12 )cycloalkyl(C 1-5 )alkyl, hetero(C 3-12 )cycloalkyl(C 1-10 )alkyl, aryl(C 1-10 )alkyl, hetero(C 1-10 )aryl(C 1-5 )alkyl, (C 9-12 )bicycloaryl(C 1-5 )alkyl, hetero(C 8-12 )bicycloaryl(C 1-5 )alkyl, hetero(C 1-10 )alkyl, (C 3-12 )cycloalkyl, hetero(C 3-12 )cycloalkyl, (C 9-12 )bicycloalkyl, hetero(C 3-12 )bicycloalkyl, (C 4-12 )aryl, hetero(C 4-10 )aryl, (C 9-12 )bicycloaryl and hetero(C 4-12 )bicyoloaryl, each substituted or unsubstituted;

R 12 is selected from the group consisting of hydrogen, halo, nitro, cyano, hydroxy, (C 1-10 )alkoxy, (C 4-12 )aryloxy, hetero(C 1-10 )aryloxy, aminocarbonyl, amino, (C 1-10 )alkylamino, (C 1-10 )alkyl, halo(C 1-10 )alkyl, hydroxy(C 1-10 )alkyl, aza(C 1-10 )alkyl, (C 1-10 )oxaalkyl, (C 1-10 )oxoalkyl, (C 3-12 )cycloalkyl(C 1-5 )alkyl, hetero(C 3-12 )cycloalkyl(C 1-10 )alkyl, aryl(C 1-10 )alkyl, hetero(C 1-10 )aryl(C 1-5 )alkyl, (C 9-12 )bicycloaryl(C 1-5 )alkyl, hetero(C 8-12 )bicycloaryl(C 1-5 )alkyl, hetero(C 1-10 )alkyl, (C 3-12 )cycloalkyl, hetero(C 3-12 )cycloalkyl, (C 9-12 )bicycloalkyl, hetero(C 3-12 )bicycloalkyl, (C 4-12 )aryl, hetero(C 4-10 )aryl, (C 9-12 )bicycloaryl and hetero(C 4-12 )bicyoloaryl, each substituted or unsubstituted, or R 12 is absent when the carbon to which it is bound forms part of a double bond;

R 13 is selected from the group consisting of hydrogen, halo, nitro, cyano, hydroxy, (C 1-10 )alkoxy, (C 4-12 )aryloxy, hetero(C 1-10 )aryloxy, aminocarbonyl, amino, (C 1-10 )alkylamino, (C 1-10 )alkyl, halo(C 1-10 )alkyl, hydroxy(C 1-10 )alkyl, aza(C 1-10 )alkyl, (C 1-10 )oxaalkyl, (C 1-10 )oxoalkyl, (C 3-12 )cycloalkyl(C 1-5 )alkyl, hetero(C 3-12 )cycloalkyl(C 1-10 )alkyl, aryl(C 1-10 )alkyl, hetero(C 1-10 )aryl(C 1-5 )alkyl, (C 9-12 )bicycloaryl(C 1-5 )alkyl, hetero(C 8-12 )bicycloaryl(C 1-5 )alkyl, hetero(C 1-10 )alkyl, (C 3-12 )cycloalkyl, hetero(C 3-12 )cycloalkyl, (C 9-12 )bicycloalkyl, hetero(C 3-12 )bicycloalkyl, (C 4-12 )aryl, hetero(C 4-10 )aryl, (C 9-12 )bicycloaryl and hetero(C 4-12 )bicyoloaryl, each substituted or unsubstituted, or R 13 is absent when the carbon to which it is bound forms part of a double bond;

R 14 and R 15 are each independently selected from the group consisting of hydrogen, halo, nitro, cyano, hydroxy, (C 1-10 )alkoxy, (C 4-12 )aryloxy, hetero(C 1-10 )aryloxy, aminocarbonyl, amino, (C 1-10 )alkylamino, (C 1-10 )alkyl, halo(C 1-10 )alkyl, hydroxy(C 1-10 )alkyl, aza(C 1-10 )alkyl, (C 1-10 )oxaalkyl, (C 1-10 )oxoalkyl, (C 3-12 )cycloalkyl(C 1-5 )alkyl, hetero(C 3-12 )cycloalkyl(C 1-10 )alkyl, aryl(C 1-10 )alkyl, hetero(C 1-10 )aryl(C 1-5 )alkyl, (C 9-12 )bicycloaryl(C 1-5 )alkyl, hetero(C 8-12 )bicycloaryl(C 1-5 )alkyl, hetero(C 1-10 )alkyl, (C 3-12 )cycloalkyl, hetero(C 3-12 )cycloalkyl, (C 9 - 12 )bicycloalkyl, hetero(C 3-12 )bicycloalkyl, (C 4-12 )aryl, hetero(C 4-10 )aryl, (C 9-12 )bicycloaryl and hetero(C 4-12 )bicycloaryl, each substituted or unsubstituted, or R 15 is absent when the carbon to which it is bound forms part of a double bond;

R 16 is selected from the group consisting of hydrogen, halo, nitro, cyano, hydroxy, (C 1-10 )alkoxy, (C 4-12 )aryloxy, hetero(C 1-10 )aryloxy, aminocarbonyl, amino, (C 1-10 )alkylamino, (C 1-10 )alkyl, halo(C 1-10 )alkyl, hydroxy(C 1-10 )alkyl, aza(C 1-10 )alkyl, (C 1-10 )oxaalkyl, (C 1-10 )oxoalkyl, (C 3-12 )cycloalkyl(C 1-5 )alkyl, hetero(C 3-12 )cycloalkyl(C 1-10 )alkyl, aryl(C 1-10 )alkyl, hetero(C 1-10 )aryl(C 1-5 )alkyl, (C 9-12 )bicycloaryl(C 1-5 )alkyl, hetero(C 8-12 )bicycloaryl(C 1-5 )alkyl, hetero(C 1-10 )alkyl, (C 3-12 )cycloalkyl, hetero(C 3-12 )cycloalkyl, (C 9-12 )bicycloalkyl, hetero(C 3-12 )bicycloalkyl, (C 4-12 )aryl, hetero(C 4-10 )aryl, (C 9-12 )bicycloaryl and hetero(C 4-12 )bicycloaryl, each substituted or unsubstituted, or R 16 is absent when the nitrogen to which it is bound forms part of a double bond; and

R 19 selected from the group consisting of hydrogen, hydroxy, (C 1-10 )alkoxy, (C 4-12 )aryloxy, hetero(C 1-10 )aryloxy, aminocarbonyl, amino, (C 1-10 )alkylamino, (C 1-10 )alkyl, halo(C 1-10 )alkyl, hydroxy(C 1-10 )alkyl, aza(C 1-10 )alkyl, (C 1-10 )oxaalkyl, (C 1-10 )oxoalkyl, (C 3-12 )cycloalkyl(C 1-5 )alkyl, hetero(C 3-12 )cycloalkyl(C 1-10 )alkyl, aryl(C 1-10 )alkyl, hetero(C 1-10 )aryl(C 1-5 )alkyl, (C 9-12 )bicycloaryl(C 1-5 )alkyl, hetero(C 8-12 )bicycloaryl(C 1-5 )alkyl, hetero(C 1-10 )alkyl, (C 3-12 )cycloalkyl, hetero(C 3-12 )cycloalkyl, (C 9-12 )bicycloalkyl, hetero(C 3-12 )bicycloalkyl, (C 4-12 )aryl, hetero(C 4-10 )aryl, (C 9-12 )bicycloaryl and hetero(C 4-12 )bicycloaryl, each substituted or unsubstituted.

2. The compound according to claim 1 having the formula:

3. The compound according to claim 1 having the formula:

4. The compound according to claim 1 having the formula:

wherein R 17 and R 18 are each independently elected from the group consisting of hydrogen, halo, nitro, cyano, hydroxy, (C 1-10 )alkoxy, (C 4-12 )aryloxy, hetero(C 1-10 )aryloxy, aminocarbonyl, amino, (C 1-10 )alkylamino, (C 1-10 )alkyl, halo(C 1-10 )alkyl, hydroxy(C 1-10 )alkyl, aza(C 1-10 )alkyl, (C 1-10 )oxaalkyl, (C 1-10 )oxoalkyl, (C 3-12 )cycloalkyl(C 1-5 )alkyl, hetero(C 3-12 )cycloalkyl(C 1-10 )alkyl, aryl(C 1-10 )alkyl, hetero(C 1-10 )aryl(C 1-5 )alkyl, (C 9-12 )bicycloaryl(C 1-5 )alkyl, hetero(C 8-12 )bicycloaryl(C 1-5 )alkyl, hetero(C 1-10 )alkyl, (C 3-12 )cycloalkyl, hetero(C 3-12 )cycloalkyl, (C 9-12 )bicycloalkyl, hetero(C 3-12 )bicycloalkyl, (C 4-12 )aryl, hetero(C 4-10 )aryl, (C 9-12 )bicycloaryl and hetero(C 4-12 )bicycloaryl, each substituted or unsubstituted.

5. The compound according to claim 4 , wherein R 17 is selected from the group consisting of hydrogen, halo and a substituted or unsubstituted (C 1-3 )alkyl.

6. The compound according to claim 4 , wherein R 18 is hydrogen.

7. The compound according to claim 1 having the formula:

8. The compound according to claim 1 having the formula:

9. The compound according to claim 1 having the formula:

wherein R 19 selected from the group consisting of hydrogen, hydroxy, (C 1-10 )alkoxy, (C 4-12 )aryloxy, hetero(C 1-10 )aryloxy, aminocarbonyl, amino, (C 1-10 )alkylamino, (C 1-10 )alkyl, halo(C 1-10 )alkyl, hydroxy(C 1-10 )alkyl, aza(C 1-10 )alkyl, (C 1-10 )oxaalkyl, (C 1-10 )oxoalkyl, (C 3-12 )cycloalkyl(C 1-5 )alkyl, hetero(C 3-12 )cycloalkyl(C 1-10 )alkyl, aryl(C 1-10 )alkyl, hetero(C 1-10 )aryl(C 1-5 )alkyl, (C 9-12 )bicycloaryl(C 1-5 )alkyl, hetero(C 8-12 )bicycloaryl(C 1-5 )alkyl, hetero(C 1-10 )alkyl, (C 3-12 )cycloalkyl, hetero(C 3-12 )cycloalkyl, (C 9-12 )bicycloalkyl, hetero(C 3-12 )bicycloalkyl, (C 4-12 )aryl, hetero(C 4-10 )aryl, (C 9-12 )bicycloaryl and hetero(C 4-12 )bicycloaryl, each substituted or unsubstituted.

10. The compound according to claim 1 having the formula:

wherein R 20 selected from the group consisting of hydrogen, halo, nitro, cyano, hydroxy, (C 1-10 )alkoxy, (C 4-12 )aryloxy, hetero(C 1-10 )aryloxy, aminocarbonyl, amino, (C 1-10 )alkylamino, (C 1-10 )alkyl, halo(C 1-10 )alkyl, hydroxy(C 1-10 )alkyl, aza(C 1-10 )alkyl, (C 1-10 )oxaalkyl, (C 1-10 )oxoalkyl, (C 3-12 )cycloalkyl(C 1-5 )alkyl, hetero(C 3-12 )cycloalkyl(C 1-10 )alkyl, aryl(C 1-10 )alkyl, hetero(C 1-10 )aryl(C 1-5 )alkyl, (C 9-12 )bicycloaryl(C 1-5 )alkyl, hetero(C 8-12 )bicycloaryl(C 1-5 )alkyl, hetero(C 1-10 )alkyl, (C 3-12 )cycloalkyl, hetero(C 3-12 )cycloalkyl, (C 9-12 )bicycloalkyl, hetero(C 3-12 )bicycloalkyl, (C 4-12 )aryl, hetero(C 4-10 )aryl, (C 9-12 )bicycloaryl and hetero(C 4-12 )bicycloaryl, each substituted or unsubstituted.

11. The compound according to claim 10 , wherein R 20 is selected from the group consisting of hydrogen, halo, a substituted or unsubstituted (C 1-5 )alkyl, a substituted or unsubstituted aryl, a substituted or unsubstituted (C 3-12 )cycloalkyl, a substituted or unsubstituted hetero(C 4-10 )aryl, a substituted or unsubstituted hydroxy(C 1-6 )alkyl and a substituted or unsubstituted hetero(C 3-6 )cycloalkyl(C 1-4 )alkyl.

12. The compound according to claim 10 , wherein R 20 is hydrogen.

13. The compound according to claim 10 , wherein R 20 is methyl.

14. The compound according to claim 1 having the formula:

15. The compound according to claim 1 having the formula:

16. The compound according to claim 1 having the formula:

17. The compound according to claim 1 having the formula:

18. The compound according to claim 1 having the formula:

19. The compound according to claim 1 having the formula:

20. The compound according to claim 1 , wherein R 1 has the formula

wherein R 19 selected from the group consisting of hydrogen, hydroxy, (C 1-10 )alkoxy, (C 4-12 )aryloxy, hetero(C 1-10 )aryloxy, aminocarbonyl, amino, (C 1-10 )alkylamino, (C 1-10 )alkyl, halo(C 1-10 )alkyl, hydroxy(C 1-10 )alkyl, aza(C 1-10 )alkyl, (C 1-10 )oxaalkyl, (C 1-10 )oxoalkyl, (C 3-12 )cycloalkyl(C 1-5 )alkyl, hetero(C 3-12 )cycloalkyl(C 1-10 )alkyl, aryl(C 1-10 )alkyl, hetero(C 1-10 )aryl, (C 1-5 )alkyl, (C 9-12 )bicycloaryl(C 1-5 )alkyl, hetero(C 8-12 )bicycloaryl(C 1-5 )alkyl, hetero(C 1-10 )alkyl, (C 3-12 )cycloalkyl, hetero(C 3-12 )cycloalkyl, (C 9-12 )bicycloalkyl, hetero(C 3-12 )bicycloalkyl, (C 4-12 )aryl, hetero(C 4-10 )aryl, (C 9-12 )bicycloaryl and hetero(C 4-12 )bicycloaryl, each substituted or unsubstituted.

21. The compound according to claim 1 , wherein R 2 is hydrogen.

22. The compound according to claim 1 , wherein R 3 is absent.

23. The compound according to claim 1 , wherein R 4 is selected from the group consisting of hydrogen, halo and a substituted or unsubstituted (C 1-3 )alkyl.

24. The compound according to claim 1 , wherein R 5 is selected from the group consisting of hydrogen, halo and a substituted or unsubstituted (C 1-3 )alkyl.

25. The compound according to claim 1 , wherein R 6 is selected from the group consisting of hydrogen, halo and a substituted or unsubstituted (C 1-3 )alkyl.

26. The compound according to claim 1 , wherein R 7 is selected from the group consisting of hydrogen, halo and a substituted or unsubstituted (C 1-3 )alkyl.

27. The compound according to claim 1 , wherein R 8 is selected from the group consisting of hydrogen, halo and a substituted or unsubstituted (C 1-3 )alkyl.

28. The compound according to claim 1 , wherein R 9 is selected from the group consisting of hydrogen, halo and a substituted or unsubstituted (C 1-3 )alkyl.

29. The compound according to claim 1 , wherein R 10 has the formula

wherein R 20 selected from the group consisting of hydrogen, halo, nitro, cyano, hydroxy, (C 1-10 )alkoxy, (C 4-12 )aryloxy, hetero(C 1-10 0)aryloxy, aminocarbonyl, amino, (C 1-10 )alkylamino, (C 1-10 )alkyl, halo (C 1-10 )alkyl, hydroxy(C 1-10 )alkyl, aza(C 1-10 )alkyl, (C 1-10 )oxaalkyl, (C 1-10 )oxoalkyl, (C 3-12 )cycloalkyl(C 1-5 )alkyl, hetero(C 3-12 )cycloalkyl(C 1-10 )alkyl, aryl(C 1-10 )alkyl, hetero(C 1-10 )aryl(C 1-5 )alkyl, (C 9-12 )bicycloaryl(C 1-5 )alkyl, hetero (C 8-12 )bicycloaryl(C 1-5 )alkyl, hetero(C 1-10 )alkyl, (C 3-12 )cyc loalkyl, hetero(C 3-12 )cycloalkyl, (C 9-12 )bicycloalkyl, hetero(C 3-12 )bicycloalkyl, (C 4-12 )aryl, hetero(C 4-10 )aryl, (C 9-12 )bicycloaryl and hetero(C 4-12 )bicycloaryl, each substituted or unsubstituted.

30. The compound according to claim 1 , wherein R 11 is selected from the group consisting of hydrogen, halo and a substituted or unsubstituted (C 1-3 )alkyl.

31. The compound according to claim 1 , wherein R 12 is absent.

32. The compound according to claim 1 , wherein R 13 is absent.

33. The compound according to claim 1 , wherein R 14 is selected from the group consisting of hydrogen, halo and a substituted or unsubstituted (C 1-3 )alkyl.

34. The compound according to claim 1 , wherein R 15 is absent.

35. The compound according to claim 1 , wherein R 16 is absent.

36. The compound according to claim 1 , wherein R 19 is a substituted or unsubstituted (C 1-5 )alkyl.

37. The compound according to claim 1 , wherein R 19 is a substituted or unsubstituted (C 3-6 )cycloalkyl.

38. The compound according to claim 1 , wherein R 19 is a substituted or unsubstituted cyclopropyl.

39. The compound according to claim 1 , wherein the compound is in the form of a pharmaceutically acceptable salt.

40. A pharmaceutical composition comprising a compound according to claim 1 ; and

a pharmaceutically acceptable excipient.

41. A kit comprising:

a compound of claim 1 ; and

instructions which comprise one or more forms of information selected from the group consisting of indicating a disease state for which the compound is to be administered, storage information for the compound, dosing information and instructions regarding how to administer the compound.

42. An article of manufacture comprising:

a compound of claim 1 ; and

packaging materials.

43. The compound of any one of claim 18 or 19 wherein

R 2 is hydrogen;

R 5 is hydrogen;

R 6 is hydrogen;

R 7 is hydrogen;

L is selected from the group consisting of —CH 2 —, —CH(CH 3 )—, —C(CH 3 ) 2 —, —CF 2 —, and —S—;

R 8 is hydrogen;

R 9 is hydrogen;

R 10 is a substituted or unsubstituted hetero(C 1-10 )aryl; and

R 11 is hydrogen.

44. The compound according to claim 43 , wherein L is —CF 2 —.

45. The compound according to claim 44 , wherein R 10 has the formula

wherein R 20b ) is selected from the group consisting of hydrogen, (C 1-5 )alkyl, (C 4-12 )aryl, (C 3-12 )cycloalkyl, hetero(C 4-10 )aryl, hydroxy(C 1-6 )alkyl, and hetero(C 3-6 )cycloalkyl(C 1-4 )alkyl; each substituted or unsubstituted.

46. The compound according to claim 45 , wherein R 19 is a cyclopropyl unsubstituted or substituted.

47. The compound according to claim 46 , wherein R 20b is hydrogen.

48. The compound according to claim 46 , wherein R 20b is methyl.

49. A compound of claim 1 selected from the group consisting of

N-(6-([1,2,4]triazolo[4,3-a]pyridin-3-ylthio)imidazo[1,2-b]pyridazin-2-yl)cyclo -propanecarboxamide;

N-(6-(6-bromo-[1,2,4]triazolo[4,3-a]pyridin-3-ylthio)imidazo[1,2-b]pyridazin-2-yl)cyclopropanecarboxamide;

N-(6-(6-(1-methyl-1H-pyrazol-4-yl)-[1,2,4]triazolo [4,3 -a]pyridin-3 -ylthio)-imidazo [1,2-b ]pyridazin-2-yl)cyclopropanecarboxamide;

N-(6-(6-cyano-[1,2,4]triazolo[4,3-a]pyridin-3-ylthio)imidazo[1,2-b]pyridazin-2-yl)cyclopropanecarboxamide;

Cyclopropanecarboxylic acid [6-(6-bromo-benzotriazol-1-ylmethyl)-imidazo[1,2-b]pyridazin-2-yl]-amide;

N-(6-((6-methyl-1H-benzo[d][1,2,3]triazol-1-yl)methyl)imidazo[1,2-b]pyridazin-2-yl)cyclopropanecarboxamide;

Cyclopropanecarboxylic acid {6-[6-(1-methyl-1H-pyrazol-4-yl)-benzotriazol-1-ylmethyl]-imidazo[1 ,2-b]pyridazin-2-yl}-amide;

N-(6-((6-(3-fluorophenyl)-1H-benzo[d][1,2,3]triazol-1-yl)methyl)imidazo[1,2-b]pyridazin-2-yl)cyclopropanecarboxamide;

N-(6-((6-phenyl-1H-benzo[d][1,2,3]triazol-1-yl)methyl)imidazo[1,2-b]pyridazin-2-yl)cyclopropanecarboxamide;

N-(6-((6-(pyridin-3-yl)-1H-benzo[d][1,2,3]triazol-1-yl)methyl)imidazo[1,2-b]pyridazin-2-yl)cyclopropanecarboxamide;

N-(6-((6-(5-methoxypyridin-3-yl)-1H-benzo[d][1,2,3]triazol-1-yl)methyl)imidazo[1,2-b]pyridazin-2-yl)cyclopropanecarboxamide;

N-(6-((6-(3,5-dimethyl-1H-pyrazol-4-yl)-1H-benzo[d][1,2,3]triazol-1-yl)methyl)imidazo[1,2-b]pyridazin-2-yl)cyclopropanecarboxamide;

N-(6-((6-(5-(methylsulfonyl)pyridin-3-yl)-1H-benzo[d][1,2,3]triazol-1-yl)methyl)imidazo[1,2-b]pyridazin-2-yl)cyclopropanecarboxamide;

(S)-N-(6-((6-(1-(2,3-dihydroxypropyl)-1H-pyrazol-4-yl)-1H-benzo[d][1,2,3]triazol-1-yl)methyl)imidazo[1,2-b]pyridazin-2-yl)cyclopropanecarboxamide;

(R)-N-(6-((6-(1-(2,3-dihydroxypropyl)-1H-pyrazol-4-yl)-1H-benzo[d][1,2,3]triazol-1-yl)methyl)imidazo[1,2-b]pyridazin-2-yl)cyclopropanecarboxamide;

N-(6-((6-(1-(2-hydroxyethyl)-1H-pyrazol-4-yl)-1H-benzo[d][1,2,3]triazol-1-yl)methyl)imidazo[1,2-b]pyridazin-2-yl)cyclopropanecarboxamide;

N-(6-(6-isopropyl-[1,2,4]triazolo[4,3-a]pyridin-3-ylthio)imidazo[1,2-b]pyridazin-2-yl)cyclopropanecarboxamide

N-(6-(6-(1-(2-methoxyethyl)-1H-pyrazol-4-yl)-[1,2,4]triazolo[4,3-a]pyridin-3-ylthio)imidazo[1,2-b]pyridazin-2-yl)cyclopropanecarboxamide;

N-(6-(6-(1-(2-hydroxyethyl)-1H-pyrazol-4-yl)[1,2,4]triazolo[4,3-a]pyridin-3-ylthio)imidazo[1,2-b]pyridazin-2-yl)cyclopropanecarboxamide;

N-(6-(6-(4-(piperazin- 1 -yl)phenyl)-[1,2,4]triazolo[4,3-a]pyridin-3-ylthio)imidazo[1,2-b]pyridazin-2-yl)cyclopropanecarboxamide;

N-(6-(6-(2H-tetrazol-5-yl)-[1,2,4]triazolo[4,3-a]pyridin-3-ylthio)imidazo[1,2-b]pyridazin-2-yl)cyclopropanecarboxamide;

N-(6-(6-(5-(methoxymethyl)-1,2,4-oxadiazol-3-yl)-[1,2,4]triazolo[4,3-a]pyridin-3-ylthio)imidazo[1,2-b]pyridazin-2-yl)cyclopropanecarboxamide;

N-(6-(6-(2-hydroxypropan-2-yl)-[1,2,4]triazolo[4,3-a]pyridin-3-ylthio)imidazo[1,2-b]pyridazin-2-yl)cyclopropanecarboxamide;

N-(6-(6-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyridin-3-ylthio)imidazo[1,2-b]pyridazin-2-yl)cyclopropanecarboxamide;

N-(6-(6-methyl-[1,2,4]triazolo[4,3-a]pyridin-3-ylthio)imidazo[1,2-b]pyridazin-2-yl)cyclopropanecarboxamide;

N-(6-(6-(3 -fluorophenyl)-[1,2,4]triazolo[4,3 -a]pyridin-3 -ylthio)imidazo [1,2-b]pyridazin-2-yl)cyclopropanecarboxamide;

N-(6-(difluoro(6-(isoxazol-4-yl)-[1,2,4]triazolo[4,3 -a]pyridin-3-yl)methyl)imidazo [1,2-b]pyridazin-2-yl)cyclopropanecarboxamide;

N-(6-(difluoro(6-(1-(2-hydroxyethyl)-1H-pyrazol-4-yl)-[1,2,4]triazolo[4,3 -a]pyridin-3-yl)methyl)imidazo[1,2-b]pyridazin-2-yl)cyclopropanecarboxamide;

N-(6-(1-(6-bromo-[1,2,4]triazolo[4,3-a]pyridin-3-yl)ethyl)imidazo[1,2-b]pyridazin-2-yl)cyclopropanecarboxamide;

N-(6-(1-(6-(1-methyl-1H-pyrazol-4-yl)-[1,2,4]triazolo[4,3-a]pyridin-3-yl)ethyl)imidazo[1,2-b]pyridazin-2-yl)cyclopropanecarboxamide;

(S)-N-(6-(1-(6-(1-methyl-1H-pyrazol-4-yl)-[1,2,4]triazolo[4,3-a]pyridin-3-yl)ethyl)imidazo[1,2-b]pyridazin-2-yl)cyclopropanecarboxamide;

(R)-N-(6-(1-(6-(1-methyl-1H-pyrazol-4-yl)-[1,2,4]triazolo[4,3-a]pyridin-3-yl)ethyl)imidazo[1,2-b]pyridazin-2-yl)cyclopropanecarboxamide;

N-(6-(1-([1,2,4]triazolo[4,3-a]pyridin-3-yl)ethyl)imidazo[1,2-b]pyridazin-2-yl)cyclopropanecarboxamide;

N-(6-(1-(6-methyl-[1,2,4]triazolo[4,3-a]pyridin-3-yl)ethyl)imidazo[1,2-b]pyridazin-2-yl)cyclopropanecarboxamide;

N-(6-(1-(6-(4-fluorophenyl)-[1,2,4]triazolo[4,3-a]pyridin-3-yl)ethyl)imidazo[1,2-b]pyridazin-2-yl)cyclopropanecarboxamide;

N-(6-(1-(6-(4-methylthiophen-2-yl)-[1,2,4]triazolo[4,3-a]pyridin-3-yl)ethyl)imidazo[1,2-b]pyridazin-2-yl)cyclopropanecarboxamide;

N-(6-(1-(6-(1H-pyrazol-4-yl)-[1,2,4]triazolo[4,3 -a]pyridin-3-yl)ethyl)imidazo[1,2-b]pyridazin-2-yl)cyclopropanecarboxamide;

N-(6-(1-(6-(3-fluorophenyl)-[1,2,4]triazolo[4,3-a]pyridin-3-yl)ethyl)imidazo[1,2-b]pyridazin-2-yl)cyclopropanecarboxamide;

N-(6-(difluoro(6-(4-fluorophenyl)-[1,2,4]triazolo[4,3-a]pyridin-3-yl)methyl)imidazo[1,2-b]pyridazin-2-yl)cyclopropanecarboxamide;

N-(6-(difluoro(6-(pyridin-3-yl)-[1,2,4]triazolo[4,3-a]pyridin-3-yl)methyl)imidazo[1,2-b]pyridazin-2-yl)cyclopropanecarboxamide;

N-(6-(difluoro(6-(pyridin-4-yl)-[1,2,4]triazolo[4,3-a]pyridin-3-yl)methyl)imidazo[1,2-b]pyridazin-2-yl)cyclopropanecarboxamide;

N-(6-(difluoro(6-(4-isopropylphenyl)-[1,2,4]triazolo[4,3-a]pyridin-3-yl)methyl)imidazo[1,2-b]pyridazin-2-yl)cyclopropanecarboxamide;

N-(6-((6-(3,5-difluorophenyl)-[1,2,4]triazolo[4,3-a]pyridin-3-yl)difluoromethyl)imidazo[1,2-b]pyridazin-2-yl)cyclopropanecarboxamide;

N-(6-(difluoro(6-(4-methylthiophen-2-yl)-[1,2,4]triazolo[4,3-a]pyridin-3-yl)methyl)imidazo[1,2-b]pyridazin-2-yl)cyclopropanecarboxamide;

N-(6-(difluoro(6-(6-methoxypyridin-3-yl)-[1,2,4]triazolo[4,3-a]pyridin-3-yl)methyl)imidazo[1,2-b]pyridazin-2-yl)cyclopropanecarboxamide;

N-(6-(difluoro(6-(pyrimidin-5-yl)-[1,2,4]triazolo[4,3-a]pyridin-3-yl)methyl)imidazo[1,2-b]pyridazin-2-yl)cyclopropanecarboxamide;

N-(6-((6-(1H-pyrazol-4-yl)-[1,2,4]triazolo[4,3-a]pyridin-3-yl)difluoromethyl)imidazo[1,2-b]pyridazin-2-yl)cyclopropanecarboxamide;

N-(6-(difluoro(6-(4-methylpyridin-3-yl)-[1,2,4]triazolo[4,3-a]pyridin-3-yl)methyl)imidazo[1,2-b]pyridazin-2-yl)cyclopropanecarboxamide;

N-(6-(difluoro(6-(3-fluoro-5-methylphenyl)-[1,2,4]triazolo [4,3-a]pyridin-3-yl)methyl)imidazo[1,2-b]pyridazin-2-yl)cyclopropanecarboxamide;

N-(6-(6-(5-methyl-1H-1,2,4-triazol-3-yl)-[1,2,4]triazolo[4,3-a]pyridin-3-ylthio)imidazo[1,2-b]pyridazin-2-yl)cyclopropanecarboxamide;

N-(6-(6-(6-methoxypyridin-2-yl)-[1,2,4]triazolo[4,3-a]pyridin-3-ylthio)imidazo[1,2-b]pyridazin-2-yl)cyclopropanecarboxamide;

N-(6-(6-(6-methoxypyridin-3-yl)-[1,2,4]triazolo[4,3-a]pyridin-3-ylthio)imidazo[1,2-b]pyridazin-2-yl)cyclopropanecarboxamide;

N-(6-(6-(6-morpholinopyridin-3-yl)-[1,2,4]triazolo[4,3-a]pyridin-3-ylthio)imidazo[1,2-b]pyridazin-2-yl)cyclopropanecarboxamide;

N-(6-(6-(1-methyl-6-oxo-1,6-dihydropyridin-3-yl)-[1,2,4]triazolo[4,3-a]pyridin-3-ylthio)imidazo[1,2-b]pyridazin-2-yl)cyclopropanecarboxamide;

N-(6-(6-(1-ethyl-6-oxo-1,6-dihydropyridin-3-yl)-[1,2,4]triazolo[4,3-a]pyridin-3-ylthio)imidazo[1,2-b]pyridazin-2-yl)cyclopropanecarboxamide;

N-(6-(6-(2-(3-hydroxypropylamino)pyrimidin-5-yl)-[1,2,4]triazolo[4,3-a]pyridin-3-ylthio)imidazo[1,2-b]pyridazin-2-yl)cyclopropanecarboxamide;

N-(6-(6-(2-morpholinothiazol-4-yl)-[1,2,4]triazolo[4,3-a]pyridin-3-ylthio)imidazo[1,2-b]pyridazin-2-yl)cyclopropanecarboxamide; and

N-(6-(6-(3-(3-hydroxypropyl)phenyl)-[1,2,4]triazolo[4,3-a]pyridin-3-ylthio)imidazo[1,2-b]pyridazin-2-yl)cyclopropanecarboxamide;

or a pharmaceutically acceptable salt of the above-mentioned compounds.

50. A compound of claim 1 wherein the compound is N-(6-(6-chloro-[1,2,4]triazolo[4,3-a]pyridin-3-ylthio)imidazo[1,2-b]pyridazin-2-yl)cyclopropanecarboxamide or a pharmaceutically acceptable salt thereof.

51. A compound of claim 1 wherein the compound is N-(6-(difluoro(6-(1-methyl-1H -pyrazol-4-yl)-[1,2,4]triazolo[4,3-a]pyridin-3-yl)methyl)imidazo[1,2-b]pyridazin-2-yl)cyclopropanecarboxamide or a pharmaceutically acceptable salt thereof.

52. A compound of claim 1 wherein the compound is N-(6-(difluoro(6-(3-fluorophenyl)-[1,2,4]triazolo[4,3-a]pyridin-3-yl)methyl)imidazo[1,2-b]pyridazin-2-yl)cyclopropanecarboxamide or a pharmaceutically acceptable salt thereof.

53. A compound of claim 1 wherein the compound is N-(6-(6-(5-cyano-6-hydroxypyridin-3-yl)-[1,2,4]triazolo[4,3-a]pyridin-3-ylthio)imidazo[1,2-b]pyridazin-2-yl)cyclopropanecarboxamide or a pharmaceutically acceptable salt thereof.