Polypeptide sequence involved in the modulation of the immunosuppressive effect of viral proteins
The present invention relates to a polypeptide having a sequence of 7 to 20 amino acid residues, which is capable of modulating the immunosuppressive properties of a viral protein or a fragment thereof, against the host in which it is expressed (immunosuppression-modulatory sequence) when it substitutes the homologous sequence of the viral protein or fragment, the polypeptide including the minimum following consensus amino acid sequence: X 1 Y 9 Y 10 Y 11 CY 12 X 2 wherein, X 1 and X 2 are selected to impact on the immunosuppressive properties, and Y 9 to Y 12 represent variable amino acid residues.
1. An isolated protein comprising the amino acid sequence of
SEQ ID NO: 104 or SEQ ID NO: 106.
2. A composition comprising the protein of claim 1 ,
in association with a pharmaceutically acceptable carrier.
3. The isolated protein of claim 1 , consisting of the amino acid sequence of SEQ ID NO: 104 or SEQ ID NO: 106.