Nano-sized particles, processes of making, compositions and uses thereof
View Patent ↗The present invention describes methods for preparing high quality nanoparticles, i.e., metal oxide based nanoparticles of uniform size and monodispersity. The nanoparticles advantageously comprise organic alkyl chain capping groups and are stable in air and in nonpolar solvents. The methods of the invention provide a simple and reproducible procedure for forming transition metal oxide nanocrystals, with yields over 80%. The highly crystalline and monodisperse nanocrystals are obtained directly without further size selection; particle size can be easily and fractionally increased by the methods. The resulting nanoparticles can exhibit magnetic and/or optical properties. These properties result from the methods used to prepare them. Also advantageously, the nanoparticles of this invention are well suited for use in a variety of industrial applications, including cosmetic and pharmaceutical formulations and compositions.
1. A method of preparing metal oxide nanoparticles, comprising:
(a) mixing a metal acetate precursor with a non-aqueous organic solvent comprising at least one organic stabilizing ligand to form a reaction mixture;
(b) subjecting the mixture of step (a) to a temperature greater than about 100° C. for a time sufficient to allow formation of metal oxide nanoparticles and decomposition of the metal acetate; and
(c) extracting the metal oxide nanoparticles into a hydrocarbon solvent at a temperature lower than the temperature of step (b) by precipitation with a flocculating agent;
wherein the metal of the metal oxide nanoparticles has an oxidation state that is the same or less than the oxidation state of the metal of the metal acetate precursor,
wherein the metal acetate of step (a) is selected from the group consisting of iron (Fe) acetate, manganese (Mn) acetate, cobalt (Co) acetate, ruthenium (Ru), copper (Cu) acetate, scandium (Sc) acetate, titanium (Ti) acetate, vanadium (V) acetate, chromium (Cr) acetate, chromium (Cr) acetate dimer, molybdenum (Mo) acetate, molybdenum (Mo) acetate dimer, yttrium (Y) acetate, zirconium (Zr) acetate, hafnium (Hf) acetate, and nickel (Ni) acetate.
2. The method according to claim 1 , wherein the organic solvent of step (a) comprises a trialkylamine.
3. The method according to claim 2 wherein the solvent is trioctylamine.
4. The method according to claim 1 , wherein the organic stabilizing ligand is selected from the group consisting of sulfonic acid, sulfinic acid, phosphonic acid, phosphoric acid, a carboxylic acid and a thiol.
5. The method according to claim 1 , wherein the organic stabilizing ligand is oleic acid.
6. The method according to claim 1 , wherein the temperature of step (b) is from about 50° C. to about 400° C.
7. The method according to claim 6 , wherein the temperature of step (b) is from about 250° C. to about 400° C.
8. The method according to claim 1 , wherein the nanoparticles of step (c) are selected from the group consisting of zinc oxide nanoparticles, iron oxide nanoparticles, manganese oxide nanoparticles, cobalt oxide nanoparticles, ruthenium oxide nanoparticles, copper oxide nanoparticles, scandium oxide nanoparticles, titanium oxide nanoparticles, vanadium oxide nanoparticles, chromium oxide nanoparticles, molybdenum oxide nanoparticles, yttrium oxide nanoparticles, zirconium oxide nanoparticles, hafnium oxide nanoparticles, nickel oxide nanoparticles, or a mixture thereof.
9. The method according to claim 8 , wherein the nanoparticles are selected from zinc oxide, manganese oxide, or iron oxide nanoparticles.
10. The method according to claim 1 , wherein, in step (a), the anhydrous metal acetate precursor is mixed with the organic solvent to form the reaction mixture at room temperature.
11. The method according to claim 1 , wherein, in step (b), the mixture is brought to said temperature in a time period of from about 10 minutes to about 30 minutes.
12. The method according to claim 11 , wherein, in step (b), the mixture is brought to said temperature in a time period of from about 10 minutes to about 15 minutes.
13. The method according to claim 1 , wherein the mixture of step (b) is maintained at said temperature for about 45 minutes to about 1 hour to allow the formation of nanoparticles.
14. The method according to claim 1 , wherein in step (c) the hydrocarbon solvent is selected from pentane, hexane, heptane, octane, or dodecane.
15. The method according to claim 1 , wherein in step (c) the flocculating agent comprises a polar organic solvent.
16. The method according to claim 15 , wherein the polar organic solvent is methanol, ethanol, propanol, or butanol.
17. The method according to claim 1 , wherein, in step (c), the nanoparticles are extracted into an alkane solvent by precipitation with an alcohol or ketone.
18. The method according to claim 17 , wherein the nanoparticles are extracted into hexane solvent by precipitation with ethanol, followed by centrifugation and redispersion in hydrocarbon solvent.
19. The method according to claim 1 , wherein the extracted nanoparticles of step (c) are stable, monodisperse, and have uniform size.
20. The method according to claim 1 , wherein the extracted nanoparticles of step (c) have an organic outside coating.
21. The method according to claim 1 , wherein the nanoparticles have a size from about 3 nm to about 20 nm.
22. The method according to claim 1 , wherein, following step (b), the organic solvent is subjected to a second temperature of at least about 100° C. for a time sufficient to obtain nanocrystals having a specific diameter of from about 10 nm to about 40 nm.
23. The method according to claim 1 , further comprising the step of subjecting the extracted metal oxide nanoparticles obtained in step (c) to oxidation to obtain further oxidized metal oxide nanoparticles.
24. Monodisperse and stable nanoparticles produced by the method according to claim 1 .
25. The method of claim 24 , further comprising adding the monodisperse and stable nanoparticles to other ingredients to form a composition, wherein the composition is for use in the preparation of a formulation to prevent, reduce, retard, ameliorate, or eliminate photodamage and/or photoaging in a human or animal due to exposure to sunlight.
26. The method of claim 24 , further comprising adding the monodisperse and stable nanoparticles to other ingredients to form a composition, wherein the composition is for use in the preparation of a pharmaceutical formulation, drug formulation, or medicament, and further comprising a physiologically acceptable carrier, vehicle, or excipient.
27. The method of claim 24 , further comprising adding the monodisperse and stable nanoparticles to other ingredients to form a composition, wherein the composition is for use in the preparation of a cosmetic formulation.
28. The method of claim 24 , further comprising adding the monodisperse and stable nanoparticles to other ingredients to form a composition, wherein the composition is a cosmetic formulation, wherein the cosmetic formulation is selected from makeups, topical skin care products, soaps, powders, lotions, creams, ointments, sunblocks, sunscreens, conditioners, shampoos, fragrances, deodorants, deodorizers, hair colors, or hair dyes.
29. A method of preparing iron oxide nanoparticles, comprising:
(a) mixing an iron acetate precursor with an organic solvent comprising at least one organic stabilizing ligand to form a reaction mixture;
(b) subjecting the mixture of step (a) to a temperature of from about 200° C. to about 260° C. for a time sufficient to allow formation of iron oxide nanoparticles and decomposition of the iron acetate; and
(c) extracting the iron oxide nanoparticles of step (b) into a hydrocarbon solvent at a temperature lower than the temperature of step (b) by precipitation with a flocculating agent;
wherein the iron of the iron oxide nanoparticles has an oxidation state that is the same or less than the oxidation state of the iron of the iron acetate precursor.
30. A method of preparing manganese oxide nanoparticles, comprising:
(a) mixing a manganese acetate precursor with an organic solvent comprising at least one organic stabilizing ligand to form a reaction mixture;
(b) subjecting the mixture of step (a) to a temperature of from about 300° C. to about 350° C. for a time sufficient to allow formation of monodisperse manganese oxide nanoparticles and decomposition of the manganese acetate; and
(c) extracting the manganese oxide nanoparticles of step (b) into a hydrocarbon solvent at a temperature lower than the temperature of step (b) by precipitation with a flocculating agent;
wherein the manganese of the manganese oxide nanoparticles has an oxidation state that is the same or less than the oxidation state of the manganese of the manganese acetate precursor.
31. A method of preparing monodisperse, stable metal oxide nanoparticles, comprising:
(a) mixing a metal acetate precursor with a non-aqueous organic solvent comprising at least one organic stabilizing ligand to form a reaction mixture;
(b) subjecting the mixture of step (a) to a temperature of from about 150° C. to about 400° C. for a time sufficient to allow formation of metal oxide nanoparticles and decomposition of the metal acetate; and
(c) extracting the metal oxide nanoparticles into a hydrocarbon solvent at a temperature of about 100° C. or lower by precipitation with a polar organic solvent;
wherein the metal of the metal oxide nanoparticles has an oxidation state that is the same or less than the oxidation state of the metal of the metal acetate precursor,
wherein the metal acetate of step (a) is selected from the group consisting of iron (Fe) acetate, manganese (Mn) acetate, cobalt (Co) acetate, ruthenium (Ru), copper (Cu) acetate, scandium (Sc) acetate, titanium (Ti) acetate, vanadium (V) acetate, chromium (Cr) acetate, chromium (Cr) acetate dimer, molybdenum (Mo) acetate, molybdenum (Mo) acetate dimer, yttrium (Y) acetate, zirconium (Zr) acetate, hafnium (Hf) acetate, and nickel (Ni) acetate.
32. A method of preparing monodisperse, stable metal oxide nanoparticles, comprising:
(a) mixing a metal acetate precursor with a trialkylamine solvent comprising at least one organic stabilizing ligand comprising a long chain alkyl with one or more carboxylic acid functional groups to form a reaction mixture;
(b) subjecting the mixture of step (a) to a temperature of from about 150° C. to about 400° C. for a time sufficient to allow formation of metal oxide nanoparticles and decomposition of the metal acetate; and
(c) extracting the metal oxide nanoparticles into a hydrocarbon solvent at a temperature of about 100° C. or lower by precipitation with a polar organic solvent;
wherein the metal of the metal oxide nanoparticles has an oxidation state that is the same or less than the oxidation state of the metal of the metal acetate precursor,
wherein the metal acetate of step (a) is selected from the group consisting of iron (Fe) acetate, manganese (Mn) acetate, cobalt (Co) acetate, ruthenium (Ru), copper (Cu) acetate, scandium (Sc) acetate, titanium (Ti) acetate, vanadium (V) acetate, chromium (Cr) acetate, chromium (Cr) acetate dimer, molybdenum (Mo) acetate, molybdenum (Mo) acetate dimer, yttrium (Y) acetate, zirconium (Zr) acetate, hafnium (Hf) acetate, and nickel (Ni) acetate.
33. A method of preparing monodisperse, stable metal oxide nanoparticles, comprising:
(a) mixing a metal acetate precursor with a trialkylamine solvent comprising at least one organic stabilizing ligand comprising a long chain alkyl with one or more carboxylic acid functional groups to form a reaction mixture;
(b) subjecting the mixture of step (a) to a temperature of from about 250° C. to about 400° C. for a time sufficient to allow formation of metal oxide nanoparticles and decomposition of the metal acetate; and
(c) extracting the metal oxide nanoparticles into a hydrocarbon solvent at a temperature of about 100° C. or lower by precipitation with a polar organic solvent;
wherein the metal of the metal oxide nanoparticles has an oxidation state that is the same or less than the oxidation state of the metal of the metal acetate precursor,
wherein the metal acetate of step (a) is selected from the group consisting of iron (Fe) acetate, manganese (Mn) acetate, cobalt (Co) acetate, ruthenium (Ru), copper (Cu) acetate, scandium (Sc) acetate, titanium (Ti) acetate, vanadium (V) acetate, chromium (Cr) acetate, chromium (Cr) acetate dimer, molybdenum (Mo) acetate, molybdenum (Mo) acetate dimer, yttrium (Y) acetate, zirconium (Zr) acetate, hafnium (Hf) acetate, and nickel (Ni) acetate.
34. The method according to any one of claim 31 , 32 or 33 , wherein the trialkylamine is trioctylamine.
35. The method according to any one of claim 31 , 32 or 33 , wherein the organic stabilizing ligand is oleic acid.
36. The method according to any one of claim 31 , 32 or 33 , wherein, in step (a), the anhydrous metal acetate precursor is mixed with the organic solvent to form the reaction mixture at room temperature.
37. The method according to any one of claim 31 , 32 or 33 , wherein, in step (b), the mixture is brought to said temperature in a time period of from about 10 minutes to about 30 minutes.
38. The method according to any one of claim 31 , 32 or 33 , wherein the mixture of step (b) is maintained at said temperature for a time period of from about 45 minutes to about 1 hour to allow the formation of metal oxide nanoparticles.
39. The method according to any one of claim 31 , 32 or 33 , wherein in step (c) the hydrocarbon solvent is selected from pentane, hexane, heptane, octane, or dodecane.
40. The method according to any one of claim 31 , 32 or 33 , wherein the polar organic solvent is methanol, ethanol, propanol, or butanol.
41. The method according to any one of claim 31 , 32 or 33 , wherein the extracted metal oxide nanoparticles of step (c) have an organic outside coating.
42. The method according to any one of claim 31 , 32 or 33 , wherein the nanoparticles have a size of from about 2 nm to about 20 nm.
43. Monodisperse and stable nanoparticles produced by the method according to any one of claim 31 , 32 or 33 .
44. A composition comprising the nanoparticles according to claim 1 for use in the preparation of a formulation to prevent, reduce, retard, ameliorate, or eliminate photodamage and/or photoaging in a human or animal due to exposure to sunlight.
45. The method of claim 1 , further comprising adding the nanoparticles according to step (c) to a pharmaceutical formation, drug formulation or medicament to form a composition, wherein the composition is for use in the preparation of a pharmaceutical formulation, drug formulation, or medicament, comprising the nanoparticles and further comprising a physiologically acceptable carrier, vehicle, or excipient.
46. The method of claim 1 , further comprising adding the nanoparticles according to step (c) to a cosmetic formulation to form a cosmetic formulation comprising the nanoparticles.
47. The method of claim 1 , further comprising adding the nanoparticles according to step (c) to a makeup, topical skin care product, soap, powder, lotion, cream, ointment, conditioner, shampoo, fragrance, deodorant, deodorizer, hair color, or hair dye to form, a makeup, topical skin care product, soap, powder, lotion, cream, ointment, conditioner, shampoo, fragrance, deodorant, deodorizer, hair color, or hair dye, respectively, comprising the nanoparticles.
48. The method of any one of claim 1 , 29 , 30 , 31 , 32 or 33 , wherein the metal acetate precursor is anhydrous.