Antitumor agents
The invention provides compounds of formula I: wherein Y is F or Br; or a pharmaceutically acceptable salt thereof. The compounds are effective antitumor agents. The invention also provides pharmaceutical compositions comprising a compound of formula I or a salt thereof, intermediates useful for preparing a compound of formula I, therapeutic methods comprising administering a compound of formula I or a salt thereof to a mammal in need thereof, and methods of inhibiting cancer cells.
1. A therapeutic method to treat cancer in a mammal, comprising administering to a mammal in need of such therapy an effective amount of a compound of formula I:
wherein Y is Br;
or a pharmaceutically acceptable salt thereof;
wherein the cancer comprises breast cancer.
2. The method of claim 1 wherein the carbon bearing the methyl group in formula I is in the (R) configuration.
3. The method of claim 1 wherein the carbon bearing the methyl group in formula I is in the (S) configuration.
4. The method of claim 1 wherein the compound of formula I is 2-(4-(7-bromo-8-methoxyquinolin-2-yloxy)phenoxy)propanoic acid.
5. The method of claim 1 wherein the compound of formula I is administered as a composition comprising the compound of formula I in combination with a pharmaceutically acceptable diluent or carrier.
6. The method of claim 5 wherein the composition is formulated for oral, parenteral, intravenous, intramuscular, subcutaneous, or topical administration.
7. A method to inhibit the growth of cancer cells comprising contacting the cells with an effective amount of a compound of formula I:
wherein Y is Br;
or a pharmaceutically acceptable salt thereof;
wherein the cancer cells comprise breast cancer cells.