G-protein coupled receptor agonists

1. A compound of formula (I):

or a pharmaceutically acceptable salt or N-oxide thereof, wherein:

one of E 1 and E 2 is N and the other is N or C-G 2 ;

the dashed line together with the solid line forms an optional double bond;

when the dashed line together with the solid line forms a double bond E 3 is CR 8 or N, and when it is a single bond E 3 is CHR 8 , O or NR 2 ;

T is O, S, or NR 2 ;

B is a bond;

Q is a 5-membered heteroaromatic ring;

A is (CH 2 ) n , where one CH 2 group may be replaced by O or NR 3 ;

n is 0, 1, 2, 3, or 4;

G 1 and G 2 are independently hydrogen, halogen, C 1-4 -alkoxy, NR 4 R 44 , or cyano; or C 1-4 -alkyl optionally substituted by hydroxy, NR 4 R 44 , or oxo;

D represents NR 1 ;

R 1 is C(O)OR 5 or heteroaryl optionally be substituted by one or two groups selected from C 1-4 alkyl, C 1-4 alkoxy, C 1-4 alkyl-OH, halogen, C 1-4 -fluoroalkyl, heterocyclyl, C(O)OC 1-4 alkyl;

R 2 and R 3 are independently hydrogen or C 1-4 alkyl;

R 4 and R 44 are independently hydrogen, C 1-4 alkyl, C 3-7 cycloalkyl, or aryl, which may optionally be substituted with 1 or 2 substituents selected from halo, C 1-4 alkyl, CF 3 , C 1-4 alkoxy, cyano, and S(O) 2 Me; or, taken together, R 4 and R 44 may form a 5- or 6-membered heterocyclic ring;

R 5 is C 1-8 alkyl, C 2-8 alkenyl or C 2-8 alkynyl, any of which may be optionally substituted by one or more halo atoms, NR 6 R 66 , OR 6 , C(O)OR 6 , OC(O)R 6 or cyano, and may contain a CH 2 group that is replaced by O or S; or a C 3-7 cycloalkyl, aryl, heterocyclyl, heteroaryl, C 1-4 alkyleneC 3-7 cycloalkyl, C 1-4 alkylenearyl, C 1-4 alkyeneheterocyclyl or C 1-4 alkyleneheteroaryl, any of which may be substituted with one or more substituents selected from halo, C 1-4 alkyl, C 1-4 fluoroalkyl, OR 7 , CN, NR 7 R 77 , SO 2 Me, NO 2 or C(O)OR 7 ;

R 6 , R 66 , R 7 , and R 77 each independently are hydrogen or C 1-4 alkyl; or, taken together, R 6 and R 66 or R 7 and R 77 may form a 5- or 6-membered heterocyclic ring;

R 8 is hydrogen, hydroxy, C 1-4 alkoxy or benzyloxy;

R 11 hydrogen;

x is 0, 1, 2 or 3; and

y is 1, 2, 3, 4 or 5;

with the proviso that x+y is 2, 3, 4 or 5.

2. The compound according to claim 1 , wherein E 3 is CH.

3. The compound according to claim 2 , wherein T is O.

4. The compound according to claim 1 , wherein Q is a 5-membered heteroaromatic ring containing up to 3 heteroatoms selected from N, O and S.

5. The compound according to claim 4 , wherein Q is an oxadiazolyl ring.

6. The compound according to claim 5 , wherein Q is [1,2,4]oxadiazolyl.

7. The compound according to claim 1 , wherein n is 1.

8. The compound according to claim 1 , wherein G 1 is hydrogen, halogen, C 1-4 alkyl, or cyano.

9. The compound according to claim 8 , wherein G 1 is hydrogen, methyl or cyano.

10. The compound according to claim 1 , wherein G 2 is hydrogen, methyl or cyano.

11. The compound according to claim 1 , wherein R 1 is C(O)OR 5 .

12. The compound according to claim 1 , which is of formula (Ia):

or a pharmaceutically acceptable salt or N-oxide thereof, wherein:

one of E 1 and E 2 is N and the other is N or C-G 2 ;

the dashed line together with the solid line forms an optional double bond;

when the dashed line together with the solid line forms a double bond E 3 is CH or N, and when it is a single bond E 3 is CH 2 or NR 2 ;

T is O, S, or NR 2 ;

Q is 5-membered heteroaromatic ring;

A is (CH 2 ) n , where one CH 2 group may be replaced by ONR 3 ;

n is 0, 1, 2, 3, or 4;

G 1 and G 2 are independently hydrogen, halogen, C 1-4 alkyl, C 2-4 -alkynyl, CF 3 , C 1-4 -alkoxy, NR 4 R 44 , or cyano;

R 1 is C(O)OR 5 or a 5- or 6-membered nitrogen-containing heteroaryl group;

R 2 and R 3 are independently hydrogen or C 1-4 alkyl;

R 4 and R 44 are independently hydrogen, C 1-4 alkyl, C 3-7 cycloalkyl, or aryl, which may optionally be substituted with 1 or 2 substituents selected from halo, C 1-4 alkyl, CF 3 , C 1-4 alkoxy, cyano, and S(O) 2 Me; or, taken together, R 4 and R 44 may form a 5- or 6-membered heterocyclic ring;

R 5 and R 55 are independently C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, any of which may optionally be substituted by cyano, CHal p H 3-p , OR 6 or NR 6 R 66 , or C 3-7 cycloalkyl or 4- to 7-membered heterocyclyl either of which may optionally be substituted with C 1-4 alkyl, or aryl or heteroaryl either of which may optionally be substituted with 1 or 2 substituents selected from halo, C 1-4 alkyl, CF 3 , OR 7 , COOR 7 , cyano, S(O) 2 Me, NR 7 R 77 , and nitro;

R 6 , R 66 , R 7 , and R 77 each independently are hydrogen or C 1-4 alkyl; or, taken together, R 6 and R 66 or R 7 and R 77 may independently form a 5- or 6-membered heterocyclic ring;

Hal is fluoro or chloro; and

p is 1, 2, or 3.

13. A compound selected from the group consisting of:

4-[5-(4-Hydroxymethylfuro[3,2-c]pyridin-2-yl)-[1,2,4]oxadiazol-3-ylmethoxy]-piperidine-1-carboxylic acid tert-butyl ester;

4-[5-(4-Methoxymethylfuro[3,2-c]pyridine-2-yl)-[1,2,4]oxadiazole-3-ylmethoxy]piperidine-1-carboxylic acid tert-butyl ester;

4-[5-(4-Dimethylaminomethylfuro[3,2-c]pyridine-2-yl)-[1,2,4]oxadiazole-3-ylmethoxy]piperidine-1-carboxylic acid tert-butyl ester;

4-[5-(4-Pyrrolidin-1-ylmethylfuro[3,2-c]pyridine-2-yl)-[1,2,4]oxadiazole-3-ylmethoxy}-piperidine-1-carboxylic acid tert-butyl ester;

4-[5-(4-Formylfuro[3,2-c]pyridine-2-yl)-[1,2,4]oxadiazole-3-ylmethoxy]piperidine-1-carboxylic acid tert-butyl ester;

4-{[(5-Furo[3,2-c]pyridin-2-yl-[1,2,4]oxadiazol-3-ylmethyl)amino]methyl}-piperidine-1-carboxylic acid tert-butyl ester;

4-[(5-Furo[3,2-c]pyridin-2-yl-[1,2,4]oxadiazol-3-ylmethyl)amino]piperidine-1-carboxylic acid tert-butyl ester;

4-[(3-Furo[3,2-c]pyridin-2-yl-[1,2,4]oxadiazol-5-ylmethyl)amino]piperidine-1-carboxylic acid tert-butyl ester;

4-[Ethyl(5-furo[3,2-c]pyridin-2-yl-[1,2,4]oxadiazol-3-ylmethyl)amino]-piperidine-1-carboxylic acid tert-butyl ester;

4-[(5-Furo[3,2-c]pyridin-2-yl-[1,2,4]oxadiazol-3-ylmethyl)propylamino]-piperidine-1-carboxylic acid tert-butyl ester;

4-[(5-Furo[3,2-c]pyridin-2-yl-[1,2,4]oxadiazol-3-ylmethyl)methylamino]-piperidine-1-carboxylic acid tert-butyl ester;

4-[(3-Furo[3,2-c]pyridin-2-yl-[1,2,4]oxadiazol-5-ylmethyl)methylamino]-piperidine-1-carboxylic acid tert-butyl ester;

4-[Ethyl(3-furo[3,2-c]pyridin-2-yl-[1,2,4]oxadiazol-5-ylmethyl)amino]-piperidine-1-carboxylic acid tert-butyl ester;

4-(5-Thieno[2,3-c]pyridin-2-yl-[1,2,4]oxadiazol-3-yl)piperidine-1-carboxylic acid tert-butyl ester;

4-(5-Thieno[3,2-c]pyridin-2-yl-[1,2,4]oxadiazol-3-ylmethoxy)piperidine-1-carboxylic acid tert-butyl ester;

4-(5-Furo[3,2-c]pyridin-2-yl-[1,2,4]oxadiazol-3-yl)piperidine-1-carboxylic acid tert-butyl ester;

4-(5-Furo[3,2-c]pyridin-2-yl-[1,2,4]oxadiazol-3-ylmethoxy)piperidine-1-carboxylic acid tert-butyl ester;

4-(5-Thieno[2,3-c]pyridin-2-yl-[1,2,4]oxadiazol-3-ylmethoxy)piperidine-1-carboxylic acid tert-butyl ester;

4-(5-Thieno[2,3-c]pyridin-2-yl-[1,2,4]oxadiazol-3-ylmethyl)piperidine-1-carboxylic acid tert-butyl ester;

4-(5-Thieno[3,2-c]pyridin-2-yl-[1,2,4]oxadiazol-3-ylmethyl)piperidine-1-carboxylic acid tert-butyl ester;

4-(5-Furo[3,2-c]pyridin-2-yl-[1,2,4]oxadiazol-3-ylmethyl)piperidine-1-carboxylic acid tert-butyl ester;

4-(5-Thieno[3,2-c]pyridin-2-yl-[1,2,4]oxadiazol-3-yl)-piperidine-1-carboxylic acid tert-butyl ester;

4-[5-(1-Methyl-1H-pyrrolo[2,3-c]pyridin-2-yl)-[1,2,4]oxadiazol-3-ylmethyl]piperidine-1-carboxylic acid tert-butyl ester;

4-[5-(1H-Pyrrolo[2,3-c]pyridin-2-yl)-[1,2,4]oxadiazol-3-ylmethoxy]piperidine-1-carboxylic acid tert-butyl ester;

4-[5-(1H-Pyrrolo[2,3-c]pyridin-2-yl)-[1,2,4]oxadiazol-3-ylmethyl]piperidine-1-carboxylic acid tert-butyl ester;

4-(5-Furo[2,3-c]pyridin-2-yl-[1,2,4]oxadiazol-3-ylmethoxy)piperidine-1-carboxylic acid tert-butyl ester;

4-(5-Furo[2,3-c]pyridin-2-yl-[1,2,4]oxadiazol-3-yl)piperidine-1-carboxylic acid tert-butyl ester;

4-[5-(1H-Pyrrolo[2,3-c]pyridin-2-yl)-[1,2,4]oxadiazol-3-yl]-piperidine-1-carboxylic acid tert-butyl ester;

4-[5-(4-Chlorofuro[3,2-c]pyridin-2-yl)-[1,2,4]oxadiazol-3-ylmethyl]piperidine-1-carboxylic acid tert-butyl ester;

4-[5-(4-Chlorofuro[3,2-c]pyridin-2-yl)-[1,2,4]oxadiazol-3-ylmethoxy]piperidine-1-carboxylic acid tert-butyl ester;

4-(3-Furo[3,2-c]pyridin-2-yl-[1,2,4]oxadiazol-5-ylmethyl)piperidine-1-carboxylic acid tert-butyl ester;

4-(3-Furo[3,2-c]pyridin-2-yl-[1,2,4]oxadiazol-5-ylmethoxy)piperidine-1-carboxylic acid tert-butyl ester;

(3S)-3-(3-Furo[3,2-c]pyridin-2-yl-[1,2,4]oxadiazol-5-ylmethoxy)pyrrolidine-1-carboxylic acid tert-butyl ester;

(3R)-(3-Furo[3,2-c]pyridin-2-yl-[1,2,4]oxadiazol-5-ylmethoxy)pyrrolidine-1-carboxylic acid tert-butyl ester;

3-(3-Furo[3,2-c]pyridin-2-yl-[1,2,4]oxadiazol-5-ylmethoxy)azetidine-1-carboxylic acid tert-butyl ester;

3-[2-(3-Furo[3,2-c]pyridin-2-yl-[1,2,4]oxadiazol-5-yl)-ethoxy]azetidine-1-carboxylic acid tert-butyl ester;

4-(5-Furo[3,2-c]pyridin-2-yl-[1,2,4]oxadiazol-3-ylmethyl)piperidine-1-carboxylic acid propyl ester;

4-(5-Furo[3,2-c]pyridin-2-yl-[1,2,4]oxadiazol-3-ylmethyl)piperidine-1-carboxylic acid isopropyl ester;

4-(5-Furo[3,2-c]pyridin-2-yl-[1,2,4]oxadiazol-3-ylmethyl)piperidine-1-carboxylic acid ethyl ester;

4-(5-Furo[3,2-c]pyridin-2-yl-[1,2,4]oxadiazol-3-ylmethyl)piperidine-1-carboxylic acid isobutyl ester;

4-(5-Furo[3,2-c]pyridin-2-yl-[1,2,4]oxadiazol-3-ylmethyl)piperidine-1-carboxylic acid cyclopropylmethyl ester;

4-(5-Furo[3,2-c]pyridin-2-yl-[1,2,4]oxadiazol-3-ylmethyl)piperidine-1-carboxylic acid 2-methoxycarbonyl-2-methylpropyl ester;

4-(5-Furo[3,2-c]pyridin-2-yl-[1,2,4]oxadiazol-3-ylmethyl)piperidine-1-carboxylic acid (S)-sec-butyl ester;

4-(5-Furo[3,2-c]pyridin-2-yl-[1,2,4]oxadiazol-3-ylmethyl)piperidine-1-carboxylic acid cyclobutyl ester;

4-(5-Furo[3,2-c]pyridin-2-yl-[1,2,4]oxadiazol-3-ylmethyl)piperidine-1-carboxylic acid 1-methoxycarbonyl-1-methylethyl ester;

4-(5-Furo[3,2-c]pyridin-2-yl-[1,2,4]oxadiazol-3-ylmethyl)piperidine-1-carboxylic acid 1-methyl-cyclobutyl ester;

4-(5-Furo[3,2-c]pyridin-2-yl-[1,2,4]oxadiazol-3-ylmethyl)piperidine-1-carboxylic acid (R)-tetrahydrofuran-2-ylmethyl ester;

4-(5-Furo[3,2-c]pyridin-2-yl-[1,2,4]oxadiazol-3-ylmethyl)piperidine-1-carboxylic acid 2-ethoxy-ethyl ester;

4-(5-Furo[3,2-c]pyridin-2-yl-[1,2,4]oxadiazol-3-ylmethyl)piperidine-1-carboxylic acid 1-methyl-cyclopropyl ester;

2-[3-(1-Pyrimidin-2-ylpiperidin-4-ylmethyl)-[1,2,4]oxadiazol-5-yl]furo[3,2-c]pyridine;

4-(5-Furo[3,2-c]pyridin-2-yl-[1,2,4]oxadiazol-3-ylmethyl)piperidine-1-carboxylic acid 1-carboxy-1-methylethyl ester;

4-(5-Furo[3,2-c]pyridin-2-yl-[1,2,4]oxadiazol-3-ylmethyl)piperidine-1-carboxylic acid 2-carboxy-2-methylpropyl ester;

4-[5-(5-Oxyfuro[3,2-c]pyridin-2-yl)-[1,2,4]oxadiazol-3-ylmethyl]piperidine-1-carboxylic acid tert-butyl ester;

4-[5-(4-Cyanofuro[3,2-c]pyridin-2-yl)-[1,2,4]oxadiazol-3-ylmethyl]piperidine-1-carboxylic acid tert-butyl ester;

4-[5-(7-Cyanofuro[2,3-c]pyridin-2-yl)-[1,2,4]oxadiazol-3-ylmethoxy]piperidine-1-carboxylic acid tert-butyl ester;

4-[5-(4-Cyanofuro[3,2-c]pyridin-2-yl)-[1,2,4]oxadiazol-3-ylmethoxy]piperidine-1-carboxylic acid tert-butyl ester;

4-[5-(4-Cyanothieno[3,2-c]pyridin-2-yl)-[1,2,4]oxadiazol-3-ylmethoxy]piperidine-1-carboxylic acid tert-butyl ester;

4-[5-(4-Cyanofuro[3,2-c]pyridin-2-yl)-[1,2,4]oxadiazol-3-ylmethyl]piperidine-1-carboxylic acid propyl ester;

4-[5-(4-Cyanofuro[3,2-c]pyridin-2-yl)-[1,2,4]oxadiazol-3-ylmethyl]piperidine-1-carboxylic acid isopropyl ester;

4-[5-(4-Cyanofuro[3,2-c]pyridin-2-yl)-[1,2,4]oxadiazol-3-ylmethyl]piperidine-1-carboxylic acid isobutyl ester;

4-[5-(4-Cyanofuro[3,2-c]pyridin-2-yl)-[1,2,4]oxadiazol-3-ylmethyl]piperidine-1-carboxylic acid ethyl ester;

4-[5-(4-Cyanofuro[3,2-c]pyridin-2-yl)-[1,2,4]oxadiazol-3-ylmethyl]piperidine-1-carboxylic acid cyclobutyl ester;

4-[5-(4-Cyanofuro[3,2-c]pyridin-2-yl)-[1,2,4]oxadiazol-3-ylmethyl]piperidine-1-carboxylic acid tetrahydropyran-4-yl ester;

4-[5-(4-Cyanofuro[3,2-c]pyridin-2-yl)-[1,2,4]oxadiazol-3-ylmethyl]piperidine-1-carboxylic acid (R)-sec-butyl ester;

4-[5-(4-Cyanofuro[3,2-c]pyridin-2-yl)-[1,2,4]oxadiazol-3-ylmethyl]piperidine-1-carboxylic acid tetrahydrofuran-2-ylmethyl ester;

4-[5-(4-Cyanofuro[3,2-c]pyridin-2-yl)-[1,2,4]oxadiazol-3-ylmethyl]piperidine-1-carboxylic acid (R)-tetrahydrofuran-2-ylmethyl ester;

4-[5-(4-Cyanofuro[3,2-c]pyridin-2-yl)-[1,2,4]oxadiazol-3-ylmethyl]piperidine-1-carboxylic acid (R)-tetrahydrofuran-3-yl ester;

4-[5-(4-Cyanofuro[3,2-c]pyridin-2-yl)-[1,2,4]oxadiazol-3-ylmethyl]piperidine-1-carboxylic acid tetrahydrothiopyran-4-yl ester;

4-[5-(4-Cyanofuro[3,2-c]pyridin-2-yl)-[1,2,4]oxadiazol-3-ylmethyl]piperidine-1-carboxylic acid 1-methoxycarbonyl-1-methylethyl ester;

4-[5-(4-Cyanofuro[3,2-c]pyridin-2-yl)-[1,2,4]oxadiazol-3-ylmethyl]piperidine-1-carboxylic acid methoxycarbonyl methyl ester;

4-[5-(4-Cyanofuro[3,2-c]pyridin-2-yl)-[1,2,4]oxadiazol-3-ylmethyl]piperidine-1-carboxylic acid cyclopropylmethyl ester;

4-[5-(4-Cyanofuro[3,2-c]pyridin-2-yl)-[1,2,4]oxadiazol-3-ylmethyl]piperidine-1-carboxylic acid 3-ethoxy-propyl ester;

4-[5-(4-Cyanofuro[3,2-c]pyridin-2-yl)-[1,2,4]oxadiazol-3-ylmethyl]piperidine-1-carboxylic acid (S)-sec-butyl ester;

4-[5-(4-Cyanofuro[3,2-c]pyridin-2-yl)-[1,2,4]oxadiazol-3-ylmethyl]piperidine-1-carboxylic acid 3-methyl-oxetan-3-ylmethyl ester;

4-[5-(4-Cyanofuro[3,2-c]pyridin-2-yl)-[1,2,4]oxadiazol-3-ylmethyl]piperidine-1-carboxylic acid 2-ethoxy-ethyl ester;

4-[5-(4-Cyanofuro[3,2-c]pyridin-2-yl)-[1,2,4]oxadiazol-3-ylmethyl]piperidine-1-carboxylic acid 2-methoxy-1-methylethyl ester;

4-[5-(4-Cyanofuro[3,2-c]pyridin-2-yl)-[1,2,4]oxadiazol-3-ylmethyl]piperidine-1-carboxylic acid tetrahydrofuran-3-ylmethyl ester;

4-[5-(4-Cyanofuro[3,2-c]pyridin-2-yl)-[1,2,4]oxadiazol-3-ylmethyl]piperidine-1-carboxylic acid (S)-tetrahydrofuran-3-yl ester;

4-[5-(4-Cyanofuro[3,2-c]pyridin-2-yl)-[1,2,4]oxadiazol-3-ylmethyl]piperidine-1-carboxylic acid tetrahydropyran-2-ylmethyl ester;

4-[5-(4-Cyanofuro[3,2-c]pyridin-2-yl)-[1,2,4]oxadiazol-3-ylmethyl]piperidine-1-carboxylic acid 1-methyl-cyclopropyl ester;

4-[5-(4-Cyanofuro[3,2-c]pyridin-2-yl)-[1,2,4]oxadiazol-3-ylmethyl]piperidine-1-carboxylic acid 1-methyl-cyclobutyl ester;

4-[5-(4-Cyanofuro[3,2-c]pyridin-2-yl)-[1,2,4]oxadiazol-3-ylmethyl]piperidine-1-carboxylic acid 1-cyclopropylethyl ester;

4-[5-(4-Cyanofuro[3,2-c]pyridin-2-yl)-[1,2,4]oxadiazol-3-ylmethyl]piperidine-1-carboxylic acid 1-methyl-cyclopropylmethyl ester;

4-[5-(4-Cyanofuro[3,2-c]pyridin-2-yl)-[1,2,4]oxadiazol-3-ylmethyl]piperidine-1-carboxylic acid 2-methyl-cyclopropylmethyl ester;

4-[5-(4-Cyanofuro[3,2-c]pyridin-2-yl)-[1,2,4]oxadiazol-3-ylmethyl]piperidine-1-carboxylic acid 3-methoxypropyl ester;

4-[5-(4-Cyanofuro[3,2-c]pyridin-2-yl)-[1,2,4]oxadiazol-3-ylmethyl]piperidine-1-carboxylic acid 3-acetoxypropyl ester;

4-[5-(4-Cyanofuro[3,2-c]pyridin-2-yl)-[1,2,4]oxadiazol-3-ylmethyl]piperidine-1-carboxylic acid oxetan-3-yl ester;

4-[5-(4-Cyanofuro[3,2-c]pyridin-2-yl)-[1,2,4]oxadiazol-3-ylmethyl]piperidine-1-carboxylic acid 1-oxo-hexahydro-1λ 4 -thiopyran-4-yl ester;

4-[5-(4-Cyanofuro[3,2-c]pyridin-2-yl)-[1,2,4]oxadiazol-3-ylmethyl]piperidine-1-carboxylic acid 1,1-dioxo-hexahydro-1λ 6 -thiopyran-4-yl ester;

4-[5-(3-Benzyloxyfuro[3,2-c]pyridin-2-yl)-[1,2,4]oxadiazol-3-ylmethyl]-piperidine-1-carboxylic acid tert-butyl ester;

4-[5-(3-Hydroxyfuro[3,2-c]pyridin-2-yl)-[1,2,4]oxadiazol-3-ylmethyl]-piperidine-1-carboxylic acid tert-butyl ester;

4-[5-(4-Methylfuro[3,2-c]pyridin-2-yl)-[1,2,4]oxadiazol-3-ylmethyl]piperidine-1-carboxylic acid tert-butyl ester;

4-[5-(7-Iodofuro[3,2-c]pyridin-2-yl)-[1,2,4]oxadiazol-3-ylmethyl]piperidine-1-carboxylic acid tert-butyl ester;

4-Chloro-2-[3-(1-pyrimidin-2-ylpiperidin-4-yloxymethyl)-[1,2,4]oxadiazol-5-yl]furo[3,2-c]pyridine;

2-(3-((1-(3-Methoxypyridin-2-yl)piperidin-4-yl)methyl)-[1,2,4]-oxadiazol-5-yl)furo[3,2-c]pyridine;

Ethyl 6-(4-((5-(furo[3,2-c]pyridin-2-yl)-[1,2,4]-oxadiazol-3-yl)methyl)piperidin-1-yl)nicotinate;

2-{3-[1-(4,6-Dimethylpyrimidin-2-yl)piperidin-4-ylmethyl]-[1,2,4]oxadiazol-5-yl}-furo[3,2-c]pyridine;

4-(5-Furo[3,2-c]pyridin-2-yl-[1,2,4]oxadiazol-3-ylmethyl)-3,4,5,6-tetrahydro-2H-[1,2′]bipyridinyl-3′-carboxylic acid ethyl ester;

2-[4-(5-Furo[3,2-c]pyridin-2-yl-[1,2,4]oxadiazol-3-ylmethyl)piperidin-1-yl]-quinoline;

1-[4-(5-Furo[3,2-c]pyridin-2-yl-[1,2,4]oxadiazol-3-ylmethyl)piperidin-1-yl]-isoquinoline;

2-[3-(1-Pyrazin-2-yl-piperidin-4-ylmethyl)-[1,2,4]oxadiazol-5-yl]-furo[3,2-c]pyridine;

2-{3-[1-(4-Methoxypyrimidin-2-yl)-piperidin-4-ylmethyl]-[1,2,4]oxadiazol-5-yl}-furo[3,2-c]pyridine;

[4-(5-Furo[3,2-c]pyridin-2-yl-[1,2,4]oxadiazol-3-ylmethyl)-3,4,5,6-tetrahydro-2H-[1,2′]bipyridinyl-5′-yl]-methanol;

2-{3-[1-(5-Ethylpyrimidin-2-yl)-piperidin-4-ylmethyl]-[1,2,4]oxadiazol-5-yl}-furo[3,2-c]pyridine;

2′-Chloro-4-(5-furo[3,2-c]pyridin-2-yl-[1,2,4]oxadiazol-3-ylmethyl)-3,4,5,6-tetrahydro-2H-[1,4′]bipyridinyl;

4′-Chloro-4-(5-furo[3,2-c]pyridin-2-yl-[1,2,4]oxadiazol-3-ylmethyl)-3,4,5,6-tetrahydro-2H-[1,2′]bipyridinyl;

2-[4-(5-Furo[3,2-c]pyridin-2-yl-[1,2,4]oxadiazol-3-ylmethyl)piperidin-1-yl]-quinoxaline;

4-(5-Furo[3,2-c]pyridin-2-yl-[1,2,4]oxadiazol-3-ylmethyl)-6′-methyl-3,4,5,6-tetrahydro-2H-[1,2′]bipyridinyl;

2-{3-[1-(6-Methylpyridazin-3-yl)piperidin-4-ylmethyl]-[1,2,4]oxadiazol-5-yl}-furo[3,2-c]pyridine;

[4-(5-Furo[3,2-c]pyridin-2-yl-[1,2,4]oxadiazol-3-ylmethyl)-3,4,5,6-tetrahydro-2H-[1,2′]bipyridinyl-4′-yl]-methanol;

4-(5-Furo[3,2-c]pyridin-2-yl-[1,2,4]oxadiazol-3-ylmethyl)-5′-methyl-3,4,5,6-tetrahydro-2H-[1,2′]bipyridinyl;

4-(5-Furo[3,2-c]pyridin-2-yl-[1,2,4]oxadiazol-3-ylmethyl)-4′-methyl-3,4,5,6-tetrahydro-2H-[1,2′]bipyridinyl;

2-{3-[1-(5-Propylpyrimidin-2-yl)-piperidin-4-ylmethyl]-[1,2,4]oxadiazol-5-yl}-furo[3,2-c]pyridine;

2-{3-[1-(1H-Benzoimidazol-2-yl)-piperidin-4-ylmethyl]-[1,2,4]oxadiazol-5-yl}-furo[3,2-c]pyridine;

4-(5-Furo[3,2-c]pyridin-2-yl-[1,2,4]oxadiazol-3-ylmethyl)-3,4,5,6-tetrahydro-2H-[1,2′]bipyridinyl;

2-{3-[1-(Furo[3,2-c]pyridin-4-yl)piperidin-4-ylmethyl]-[1,2,4]oxadiazol-5-yl}-furo[3,2-c]pyridine;

2-{3-[1-(2-Chloropyrimidin-4-yl)piperidin-4-ylmethyl]-[1,2,4]oxadiazol-5-yl}-furo[3,2-c]pyridine;

or a pharmaceutically acceptable salt or N-oxide thereof.

14. A pharmaceutical composition comprising a compound according claim 1 , or a pharmaceutically acceptable salt or N-oxide thereof, and a pharmaceutically acceptable carrier.