IP Library Granted Patent US 8,195,021
Granted Patent B2
US 8,195,021 · App. 12/513,387 · Granted Jun 5, 2012

Biopolymer optical waveguide and method of manufacturing the same

Assignee: Tufts University/Trustees of Tufts College
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Quick Facts
Patent No.
US 8,195,021
App. No.
12/513,387
Granted
Jun 5, 2012
Kind
B2
Abstract

A method of manufacturing a biopolymer optical waveguide includes providing a biopolymer, unwinding the biopolymer progressively to extract individual biopolymer fibers, and putting the unwound fibers under tension. The tensioned fibers are then cast in a different polymer to form a biopolymer optical waveguide that guides light due to the difference in indices of refraction between the biopolymer and the different polymer. The optical fibers may be used in biomedical applications and can be inserted in the body as transmissive media. Printing techniques may be used to manufacture the biopolymer optical waveguides.

Claims (37)

1. A method of manufacturing a biopolymer optical waveguide comprising:

providing a first biopolymer, wherein the biopolymer comprises a protein having a beta-sheet secondary structure; and

casting said first biopolymer in a second polymer to form a biopolymer optical waveguide, the second polymer forming a polymer overcoat cladding proximate to the first biopolymer, wherein said first biopolymer and said second polymer have different indices of refraction.

2. The method of manufacturing the biopolymer optical waveguide of claim 1 , wherein said providing of said first biopolymer includes unwinding said first biopolymer to extract individual biopolymer fibers.

3. The method of manufacturing the biopolymer optical waveguide of claim 2 , further comprising tensioning said first biopolymer.

4. The method of manufacturing the biopolymer optical waveguide of claim 1 , wherein said first biopolymer is silk.

5. The method of manufacturing the biopolymer optical waveguide of claim 4 , wherein said second polymer is polydimethylsiloxane (PDMS).

6. The method of manufacturing the biopolymer optical waveguide of claim 1 , wherein said first biopolymer has a higher index of refraction than said second polymer.

7. The method of manufacturing the biopolymer optical waveguide of claim 1 , further comprising:

treating the first biopolymer to remove surface roughness.

8. The method of manufacturing the biopolymer optical waveguide of claim 7 , wherein said treating the first biopolymer to remove surface roughness is performed using laser ablation.

9. The method of manufacturing the biopolymer optical waveguide of claim 1 , wherein said first biopolymer and said polymer overcoat form a concentric biopolymer waveguide along a longitudinal axis.

10. The method of manufacturing the biopolymer optical waveguide of claim 1 , wherein said first biopolymer and said polymer overcoat form a rectangular slab waveguide along a planar axis.

11. The method of manufacturing the biopolymer optical waveguide of claim 1 , wherein said first biopolymer comprises chitosan, collagen, gelatin, agarose, chitin, polyhydroxyalkanoates, pullan, starch (amylose amylopectin), cellulose, hyaluronic acid, or a combination thereof.

12. A method of manufacturing a biopolymer optical waveguide comprising:

providing a substrate;

printing a first biopolymer on said substrate, wherein the biopolymer comprises a protein having a beta-sheet secondary structure;

depositing a second material on said first biopolymer to form said biopolymer optical waveguide, said second material having a lower index of refraction than said first biopolymer.

13. The method of manufacturing a biopolymer optical waveguide of claim 12 , wherein said printing said first biopolymer on said substrate includes forming a layer of said first biopolymer, wherein said first biopolymer is a protein, and wherein said printing said first biopolymer is performed using an inkjet printer.

14. The method of manufacturing a biopolymer optical waveguide of claim 12 , further comprising:

overlay printing said first biopolymer to increase thickness of said biopolymer waveguide.

15. The method of manufacturing the biopolymer optical waveguide of claim 12 , wherein said first biopolymer is silk.

16. The method of manufacturing the biopolymer optical waveguide of claim 15 , wherein said second polymer is polydimethylsiloxane (PDMS).

17. The method of manufacturing the biopolymer optical waveguide of claim 12 , further comprising:

treating the first biopolymer to remove surface roughness.

18. The method of manufacturing the biopolymer optical waveguide of claim 17 , wherein said treating the first biopolymer to remove surface roughness is performed using laser ablation.

19. The method of manufacturing the biopolymer optical waveguide of claim 12 , wherein said first biopolymer comprises chitosan, collagen, gelatin, agarose, chitin, polyhydroxyalkanoates, pullan, starch (amylose amylopectin), cellulose, hyaluronic acid, or a combination thereof.

20. The method of manufacturing the biopolymer optical waveguide of claim 12 , wherein said substrate is a template for an optical device.

21. The method of manufacturing the biopolymer optical waveguide of claim 20 , wherein said substrate is a template for at least one of a lens, a microlens array, an optical grating, a pattern generator, and a beam reshaper.

22. A biopolymer optical waveguide comprising:

a first biopolymer, wherein the biopolymer comprises a protein having a beta-sheet secondary structure; and

a second material covering said first biopolymer to form said biopolymer optical waveguide, said second material having a lower index of refraction than said first biopolymer.

23. The biopolymer optical waveguide of claim 22 , wherein said biopolymer optical waveguide is an in vivo diagnostic light delivery device.

24. The biopolymer optical waveguide of claim 23 , wherein said in vivo diagnostic light delivery device is a light enabled nervous system replacement for damaged neurons.

25. The biopolymer optical waveguide of claim 22 , wherein said biopolymer optical waveguide is a transmissive media for optical radiation that relays information from sensors.

26. The biopolymer optical waveguide of claim 25 , wherein said transmissive media relays information from locations within a body.

27. The biopolymer optical waveguide of any one of claims 22 - 26 , wherein the protein is silk fibroin.

Assignments (3)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Aug 16, 2011
From: OMENETTO, FIORENZO
To: TUFTS UNIVERSITY/TRUSTEES OF TUFTS COLLEGE
Reel/Frame 026757/0659 →
CONFIRMATORY LICENSE Recorded Nov 17, 2009
From: TUFTS UNIVERSITY BOSTON
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 023528/0098 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded May 20, 2009
From: KAPLAN, DAVID; OMENETTO, FIORENZO; LAWRENCE, BRIAN; CRONIN-GOLOMB, MARK; GEORGAKOUDI, IRENE
To: TRUSTEES OF TUFTS COLLEGE
Reel/Frame 022712/0016 →
Continuity (2)
Provisional Application 60856297 · Nov 3, 2006
Related Publication 20100063404A1 · Mar 11, 2010