Human immunodeficiency virus integrase—Transportin—SR protein—protein interactions

Assignee: Laboratoire Biodim

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Quick Facts

Patent No.: US 8,197,821
App. No.: 12/072,390
Granted: Jun 12, 2012
Kind: B2

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Abstract

The present invention relates to protein-protein interactions involved in AIDS. More specifically, the present invention relates to complexes of polypeptides or polynucleotides encoding the polypeptides, fragments of the polypeptides, antibodies to the complexes, Selected Interacting Domains (SID®) which are identified due to the protein-protein interactions, methods for screening drugs for agents which modulate the interaction of proteins and pharmaceutical compositions that are capable of modulating the protein-protein interactions.

Claims (2)

1. An isolated and purified human immunodeficiency virus (HIV) integrase/Transportin-SR complex, wherein the HIV integrase has a selected interacting domain having a sequence comprising SEQ ID NO:128, and the Transportin-SR has a selected interacting domain having a sequence comprising SEQ ID NO:40.

2. An isolated and purified HIV integrase/Transportin-SR complex, wherein the HIV integrase has a selected interacting domain having a sequence consisting of SEQ ID NO:128, and the Transportin-SR has a selected interacting domain having a sequence consisting of SEQ ID NO:40.

Assignments (5)

CORRECTIVE ASSIGNMENT TO CORRECT THE THE IDENTITY OF ONE OF THE CO-OWNERS, INSERM-TRANSFERT SA PREVIOUSLY RECORDED ON REEL 029547 FRAME 0675. ASSIGNOR(S) HEREBY CONFIRMS THE CORRECT CO-OWNER SHOULD BE INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM). Recorded Feb 4, 2014

From: CELLVIR

To: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (20 PERCENT INTEREST); UNIVERSITE PARIS DESCARTES (10 PERCENT INTEREST); INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (20 PERCENT INTEREST)

Reel/Frame 032157/0178 →

ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Dec 31, 2012

From: CELLVIR

To: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (20 PERCENT INTEREST); PARIS DESCARTES UNIVERSITY (10 PERCENT INTEREST); INSERM-TRANSFERT S.A. (20 PERCENT INTEREST)

Reel/Frame 029547/0675 →

MERGER Recorded Jan 21, 2011

From: CELLVIR

To: LABORATOIRE BIODIM

Reel/Frame 025697/0840 →

ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Mar 11, 2010

From: LEGRAIN, PIERRE; RAIN, JEAN-CHRISTOPHE; BENAROUS, RICHARD; EMILIANI, STEPHANE; BERLIOZ-TORRENT, CLARISSA; BLOT, GUILLAUME

To: HYBRIGENICS S.A.

Reel/Frame 024063/0898 →

ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Mar 11, 2010

From: HYBRIGENICS S.A.

To: CELLVIR