Compositions for alleviating inflammation and oxidative stress in a mammal
An antioxidant-promoting composition that increases antioxidant defense potential in a subject is disclosed comprising Bacopa monniera extract; milk thistle extract, ashwagandha powder, green tea extract, Gotu kola powder, Ginko biloba leaf extract; Aloe vera powder; turmeric extract; and N-acetyl cysteine. The antioxidant-promoting composition of the invention safely induces cellular antioxidant potential to achieve an overall net decrease in oxidative stress without the undesirable side-effects associated with the individual components of the antioxidant-promoting composition. Also disclosed is a method for reducing the undesirable side-effects of free radicals in a subject by administering to a subject in need of such antioxidants an effective amount of antioxidant-promoting composition of the invention.
1. A composition comprising:
Bacopa monniera extract having at least 20 percent bacosides, wherein the Bacopa monniera extract is in an amount selected from the group consisting of at least about 150 mg and about 22 weight percent;
Silybum marianum (milk thistle) extract having 70 percent to about 80 percent silymarin, wherein the milk thistle extract is in an amount selected from the group consisting of at least about 225 mg and about 33 weight percent;
Withania somnifera (ashwagandha) powder in an amount selected from the group consisting of at least about 150 mg and about 22 weight percent;
Camellia sinensis (green tea) extract in an amount selected from the group consisting of at least about 75 mg and about 11 weight percent, wherein said green tea extract is comprised of at least 40 percent epigallocatechin gallate and about 98% polyphenols; and
Curcuma longa (turmeric) extract, wherein said turmeric extract is comprised of at least about 95 percent curcumin and wherein the turmeric extract is in an amount selected from the group consisting of at least about 75 mg and about 11 weight percent;
wherein the composition increases the enzyme activity level of at least one antioxidant enzyme selected from the group consisting of: superoxide dismutase and catalase and decreases the plasma concentration level of thiobarbituric acid reactive chemical species, when administered in an effective amount to a mammalian subject in need thereof.
2. The composition according to claim 1 comprising about 22 percent Bacopa monniera extract, about 33 percent milk thistle extract, about 22 percent ashwagandha powder, about 11 percent green tea, and about 11 percent turmeric extract.
3. The composition according to claim 2 wherein the composition is formulated as an oral dosage form.
4. The composition according to claim 3 , wherein the oral dosage form is selected from the group consisting of: a tablet; capsule; and caplet.
5. The composition according to claim 1 , further comprising one or more excipients selected from the group consisting of calcium carbonate; croscarmellose sodium; dicalcium phosphate; magnesium stearate; microcrystalline cellulose; modified cellulose; silica; and stearic acid.
6. A composition comprising: about 22 weight percent Bacopa monniera extract comprised of about 45 percent bacosides; about 33 weight percent Silybum marianum (milk thistle) extract, wherein said milk thistle extract is comprised of between about 70 percent and about 80 percent silymarin; about 22 weight percent Withania somnifera (ashwagandha) powder; Camellia sinensis (green tea extract), wherein said green tea extract is comprised of 98 percent polyphenols; said polyphenols comprised of 45 percent (−)-epigallocatechin gallate; Curcuma longa (turmeric) extract; wherein said turmeric extract is comprised of about 95 percent curcumin; wherein the composition increases the enzyme activity level of at least one antioxidant enzyme selected from the group consisting of: superoxide dismutase and catalase and decreases the plasma concentration level of thiobarbituric acid reactive chemical species, when administered in an effective amount to a mammalian subject in need thereof.
7. The composition according to claim 6 , further comprising one or more excipients selected from the group consisting of calcium carbonate; croscarmellose sodium; dicalcium phosphate; magnesium stearate; microcrystalline cellulose; modified cellulose; silica; and stearic acid.
8. A composition comprising:
about 22 weight percent Bacopa monniera extract having 20 percent bacosides or greater;
about 33 weight percent Silybum marianum (milk thistle) extract having between about 70 percent and about 80 percent silymarin;
about 22 weight percent Withania somnifera (ashwagandha) powder;
about 11 weight percent Camellia sinensis (green tea) extract, wherein said green tea extract is comprised of about 45 percent epigallocatechin gallate and about 98% polyphenols; and
about 11 weight percent Curcuma longa (turmeric) extract, wherein said turmeric extract is comprised of about 95 percent curcumin;
wherein the composition increases the enzyme activity level of at least one antioxidant enzyme selected from the group consisting of: superoxide dismutase and catalase and decreases the plasma concentration level of thiobarbituric acid reactive chemical species, when administered in an effective amount to a mammalian subject in need thereof.
9. The composition according to claim 8 , wherein the composition is formulated as an oral dosage form.
10. The composition according to claim 9 , wherein the oral dosage form is selected from the group consisting of: a tablet; capsule; and caplet.
11. The composition according to claim 8 , further comprising one or more excipients selected from the group consisting of calcium carbonate; croscarmellose sodium; dicalcium phosphate; magnesium stearate; microcrystalline cellulose; modified cellulose; silica; and stearic acid.
12. The composition according to claim 8 , wherein the turmeric extract is standardized to contain about 95 weight percent curcumin.