Method for delivering an active agent using a hydrogel composition
New hydrogel, including a hydrogel containing cationic BSA is included in a vaccine to stimulate the immune system to increase the potency of the vaccine.
1. A method for delivering a biologically active agent to a desired location in a human or animal, wherein said method comprises administering, to the human or animal, a biodegradable hydrogel comprising a copolymer having a hydrophobic component that is a biodegradable polyhydric alcohol ester containing at least one unsaturated terminal moiety and a hydrophilic component that is poly(ethylene glycol) diacrylate having the formula:
where n is from 8 to 400, wherein the polyhydric alcohol ester originates from a polyhydric alcohol containing from 3 to 6 hydroxy groups, wherein the unsaturated terminal moiety of the hydrophobic component of the hydrogel forming system is a 2-carboxy ethenyl group and wherein said biologically active agent is entrapped in said hydrogel.
2. The method, according to claim 1 , wherein said hydrogel has entrapped therein an antigen and a cationic potentiator.
3. The method, according to claim 2 , wherein said cationic potentiator has a pI of at least 9.5.
4. The method, according to claim 2 , wherein said cationic potentiator is bovine serum albumin (BSA).