PEG-lipid conjugates for liposomes and drug delivery
View Patent ↗New diacylglycerol-polyethylene glycol (DAG-PEG) conjugates are described. A variety of linkers between the PEG chain and glycerol backbone of the DAG-PEGs may be selected to optimize liposomal formulations of pharmaceuticals and cosmetics.
1. A compound represented by the formula
where R1 is either —OH or —OCH3;
where R2 and R3 are alkyl groups having between 6 and 22 carbons; and
where X is amino.
2. The compound of claim 1 where R2 and R3 are selected from the group consisting of oleate, myristate, linoleate and palmitate.
3. The compound of claim 1 where the PEG chain consists of between about 6 and 45 subunits.
4. The compound of claim 3 where the PEG chain consists of between about 8 and 23 subunits.
5. The compound of claim 3 where the PEG chain consists of between about 12 and 23 subunits.