IP Library Granted Patent US 8,313,712
Granted Patent B2
US 8,313,712 · App. 12/660,797 · Granted Nov 20, 2012

Microfluidic valve with pressure gain

Assignee: The Board of Trustees of the Leland Stanford Junior University
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Quick Facts
Patent No.
US 8,313,712
App. No.
12/660,797
Granted
Nov 20, 2012
Kind
B2
Abstract

The current invention provide a microfluidic valve having a housing that includes a microfluid control port disposed adjacent to a microfluid exhaust port, where a movable rigid material having a first diameter is disposed in the housing between the microfluid control port and the microfluid exhaust port. The housing further includes a microfluid pressure port having a first microfluid pressure. The microfluid pressure port is connected to the microfluid exhaust port by a microfluid valve orifice having a second diameter, where the first diameter is larger than the second diameter, and when a second microfluid pressure is applied to the control port the moveable rigid material closes the microfluid valve orifice, where the first microfluid pressure is greater than the second microfluid pressure.

Claims (22)

1. A microfluidic valve, comprising:

a. an elastic polymer housing, wherein said elastic polymer housing comprises:

i. a microfluid control port disposed adjacent to a microfluid exhaust port, wherein a movable rigid material having a first diameter is disposed in said elastic polymer housing between said microfluid control port and said microfluid exhaust port;

ii. a microfluid pressure port having a first microfluid pressure, wherein said microfluid pressure port is connected to said microfluid exhaust port by a microfluid valve orifice having a second diameter, wherein said first diameter is larger than said second diameter, wherein when a second microfluid pressure is applied to said control port said moveable rigid material operates said microfluid valve orifice.

2. The microfluidic valve of claim 1 , wherein said elastic polymer housing comprises Polydimethylsiloxane (PDMS).

3. The microfluidic valve of claim 2 , wherein said microfluid pressure port is disposed in said first layer.

4. The microfluidic valve of claim 2 , wherein said microfluid valve orifice is disposed in said first layer or said second layer.

5. The microfluidic valve of claim 2 , wherein said microfluid exhaust port is disposed in said second layer.

6. The microfluidic valve of claim 2 , wherein said movable rigid material is disposed in said second layer or said third layer.

7. The microfluidic valve of claim 2 , wherein said microfluid control port is disposed in said forth layer.

8. The microfluidic valve of claim 1 , wherein said elastic polymer housing comprises a first layer disposed on a second layer, wherein said second layer is disposed on a third layer and said third layer is disposed on a fourth layer.

9. The microfluidic valve of claim 1 , wherein said control port and said rigid element are disposed to provide a pressure gain of greater than one relative to said microfluid first pressure in said microfluid pressure port.

10. The microfluidic valve of claim 1 , wherein said microfluidic valve is disposed in a logic structure selected from the group consisting of a simple buffer, a two-input AND gate, a two-input OR gate, a simple inverter, a static latch having a dual rail load enable, and a two-input to four-output binary decoder.

11. The microfluidic valve of claim 1 , wherein an area of said microfluid exhaust port is at least equal to an area of said microfluid valve orifice.

12. The microfluidic valve of claim 1 , wherein an area of said movable rigid material is at least equal to an area of said microfluid valve orifice.

13. The microfluidic valve of claim 1 , wherein an area of said microfluid control port is at least equal to an area of said microfluid exhaust port.

14. The microfluidic valve of claim 1 , wherein a thickness of said microfluid pressure port is at least equal to 0.5 times a thickness of said microfluid exhaust port.

15. The microfluidic valve of claim 1 , wherein a length of said microfluid valve orifice is at least equal to 0.5 times a thickness of said microfluid exhaust port.

16. The microfluidic valve of claim 1 , wherein a thickness of said microfluid exhaust port is at least equal to 0.05 times a minor dimension of an area of said microfluid exhaust port.

17. The microfluidic valve of claim 1 , wherein a thickness of said movable rigid material is at least equal to 0.05 times a minor dimension of an area of said movable rigid material.

18. The microfluidic valve of claim 1 , wherein a thickness of said elastic polymer housing enveloping said movable rigid material is greater than a thickness of said movable rigid material.

19. The microfluidic valve of claim 1 , wherein a thickness of said microfluid control port is at least equal to 0.5 times a thickness of said microfluid exhaust port.

Assignments (2)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 21, 2010
From: MELIN, JESSICA E.; STARK, DONALD C.; WEAVER, JAMES A.
To: LELAND STANFORD JUNIOR UNIVERSITY, THE BOARD OF TRUSTEES OF THE
Reel/Frame 024592/0407 →
CONFIRMATORY LICENSE Recorded May 5, 2010
From: STANFORD UNIVERSITY
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 024334/0947 →
Continuity (2)
Provisional Application 61209802 · Mar 10, 2009
Related Publication 20100233037A1 · Sep 16, 2010