Using of organic solvents in wet granulation of moxifloxacin
View Patent ↗This invention encompasses to obtain non-convertible solid pharmaceutical formulations of moxifloxacin anhydrous by using of wet granulation with an organic solvent or mixtures of organic solvents.
1. A wet granulation method of anhydrous moxifloxacin or its salts wherein the method utilizes a wetting agent and the wetting agent is selected from group of isopropyl alcohol, acetone, ethanol, dichloromethane or mixtures thereof.
2. The method of claim 1 , wherein the wet granulation method comprises:
(a) adding polyvinylpyrrolidone to isopropyl alcohol and mixing until the polyvinylpyrrolidone is completely dissolved;
(b) transferring and mixing Anhydrous Moxifloxacin Hydrochloride and Microcrystalline Cellulose in a granulator;
(c) adding and mixing a granulation solution from step (a) to powder mixtures from step (b);
(d) taking wet granules from the granulator to an oven and drying and sieving the granules;
(e) transferring and mixing mannitol and Croscarmellose Sodium to the mixture in a container;
(f) sieving and adding Magnesium Stearate to the mixtures in the container to produce a blend; and
(g) producing tablets from the blend by utilizing punches.
3. The method of claim 1 , wherein the anhydrous moxifloxacin salt is hydrochloride.