4-hydroxythiobenzamide derivatives of drugs
Derivatives of drugs are provided, said derivatives comprising the H2S-releasing moiety 4-hydroxythiobenzamide that is either covalently linked to the drug or forms a salt with the drug. The compounds of the present invention exhibit enhanced activity or reduced side effects or both.
1. A compound or its salt having the formula:
A-Y—X (Formula I)
wherein A is a statin selected from the group consisting of atorvastatin, cilastatin, dermostatin, fluvastatin, lovastatin, mevastatin, pravastatin sodium and simvastatin, Y is
, and X is
.
2. The compound according to claim 1 , wherein the compound is succinic acid 2-{2-[8-(2,2-dimethyl-butyryloxy)-2,6-dimethyl-1,2,6,7,8,8a-hexahydro-naphthalen-1-yl]ethyl}-6-oxo-tetrahydro-pyran-4-yl ester 4-thiocarbamoyl-phenyl ester.