Use of vitamin D receptor agonists, ligands, and precursors to treat pancreatic fibrosis
View Patent ↗This application relates to methods of treating and ameliorating fibrosis, such as fibrosis of the pancreas. In particular, the application relates to methods of using a vitamin D receptor agonist (such as vitamin D, vitamin D analogs, vitamin D precursors, and vitamin D receptor agonists precursors) for the treatment of pancreatic fibrosis.
1. A method of treating pancreatic fibrosis in a subject having pancreatic fibrosis, comprising:
administering a therapeutically effective amount of a compound selected from the group consisting of 25-hydroxy-D 3 (25-OH-D 3 ) (calcidiol); vitamin D3 (cholecalciferol); vitamin D2 (ergocalciferol), 1α, 25-dihydroxyvitamin D 3 (calcitriol), calcipotriol, and combinations thereof to a subject having pancreatic fibrosis, thereby treating the fibrosis.
2. The method of claim 1 , wherein administration comprises oral administration of the compound.
3. The method of claim 1 , wherein the compound is administered at a dose of from about 5 international units (IU) to about 50,000 IU.
4. The method of claim 1 , wherein administration comprises contacting pancreatic stellate cells with the compound, thereby treating the fibrosis.
5. The method of claim 1 , wherein the subject is a mammalian subject.
6. The method of claim 1 , wherein the compound is calcipotriol.
7. The method of claim 1 , wherein the compound is 25-hydroxy-D 3 (25-OH-D 3 ) (calcidiol).
8. The method of claim 1 , wherein the compound is vitamin D3 (cholecalciferol).
9. The method of claim 1 , wherein the compound is vitamin D2 (ergocalciferol).
10. The method of claim 1 , wherein the compound is 1α, 25-dihydroxyvitamin D 3 (calcitriol).
11. The method of claim 1 , wherein the subject is a human.
12. A method of treating pancreatic fibrosis in a human subject having pancreatic fibrosis, comprising:
administering a therapeutically effective amount of a calcipotriol to a human subject having pancreatic fibrosis, thereby treating the fibrosis.