Apolipoprotein A-I mimics
Provided are peptides, compositions thereof, and methods for treating or preventing dyslipidemia, a cardiovascular disease, endothelial dysfunction, a macrovascular disorder, or a microvascular disorder.
1. A peptide having the sequence of SEQ ID NO: 16, or a pharmaceutically acceptable salt thereof.
2. A composition comprising the peptide or pharmaceutically acceptable salt of the peptide of claim 1 , and a pharmaceutically acceptable carrier or vehicle.
3. A peptide/lipid complex, wherein the peptide is the peptide or pharmaceutically acceptable salt of the peptide of claim 1 .
4. The peptide/lipid complex of claim 3 , wherein the lipid comprises a phospholipid.
5. The peptide/lipid complex of claim 4 , wherein the phospholipid is one or more of sphingomyelin, dipalmitoylphosphatidylcholine (DPPC) and dipalmitoylphosphatidylglycerol (DPPG).
6. The peptide/lipid complex of claim 4 , wherein the lipid is a mixture of sphingomyelin and dipalmitoylphosphatidylcholine (DPPC) or dipalmitoylphosphatidylglycerol (DPPG).
7. The peptide/lipid complex of claim 4 , wherein the lipid is a mixture of sphingomyelin, dipalmitoylphosphatidylcholine (DPPC) and dipalmitoylphosphatidylglycerol (DPPG).
8. The peptide/lipid complex of claim 6 , wherein the ratio of total peptide to lipid is about 1:about 0.5 to about 1:about 5.
9. The peptide/lipid complex of claim 7 , wherein the ratio of total peptide to lipid is about 1:about 0.5 to about 1:about 5.
10. The peptide/lipid complex of claim 7 , wherein the peptide:sphingomyelin:DPPC:DPPG weight ratio is 1:1.2125:1.2125:0.075.
11. A composition comprising the peptide/lipid complex of claim 3 , and a pharmaceutically acceptable carrier or vehicle.
12. A composition comprising the peptide/lipid complex of claim 4 , and a pharmaceutically acceptable carrier or vehicle.
13. A composition comprising the peptide/lipid complex of claim 5 , and a pharmaceutically acceptable carrier or vehicle.
14. A composition comprising the peptide/lipid complex of claim 6 , and a pharmaceutically acceptable carrier or vehicle.
15. A composition comprising the peptide/lipid complex of claim 7 , and a pharmaceutically acceptable carrier or vehicle.
16. A composition comprising the peptide/lipid complex of claim 8 , and a pharmaceutically acceptable carrier or vehicle.
17. A composition comprising the peptide/lipid complex of claim 9 , and a pharmaceutically acceptable carrier or vehicle.
18. A composition comprising the peptide/lipid complex of claim 10 , and a pharmaceutically acceptable carrier or vehicle.