IP Library › Granted Patent US 8,388,981
Granted Patent B2
US 8,388,981 · App. 13/440,106 · Granted Mar 5, 2013

Patent

Inventors: John G. Hoey (Framingham, MA); Hannah Venit (Cheltenham, PA); Martin E. Adelson (East Windsor, NJ); Eli Mordechai (Robbinsville, NJ); Fernando Valois-Cruz (Bordentown, NJ)
Assignee: Medical Diagnostic Laboratories, LLC
View Patent ↗
Loading inventors, assignments & file history…
Monitor This Case
Get email alerts when status or documents change.
Order Certified Copies
Most orders are placed with the USPTO same day — all within 24 business hours.
Order via The Patent Place →
Pre-filled with this patent's details
Quick Facts
Patent No.
US 8,388,981
App. No.
13/440,106
Granted
Mar 5, 2013
Kind
B2
Abstract

Disclosed are the cloning and expression of novel antigens in Babesia microti . The recombinant polypeptides are highly immunogenic. The polypeptides of the present invention provide the basis of a diagnostic assay that is sensitive, rapid and accurate using patient's sera. Also disclosed is an IgG and IgM ELISA using two novel recombinant antigens in the diagnosis of Babesia infection.

Claims (8)

1. An isolated polypeptide having an amino acid sequence selected from the group consisting of SEQ ID NO: 2 and SEQ ID NO: 4.

2. The isolated polypeptide of claim 1 , wherein said amino acid sequence is SEQ ID NO: 2.

3. The isolated polypeptide of claim 1 , wherein said amino acid sequence is SEQ ID NO: 4.

4. A composition comprising the isolated polypeptide of claim 1 and a support.

5. The composition of claim 4 , wherein said support is selected from the group consisting of polyethylene, polypropylene and glass.

6. The composition of claim 4 , wherein said support is a microtiter well.

7. A kit comprising the isolated polypeptide of claim 1 and a packaging material.

8. The kit of claim 7 , wherein said packaging material comprises an instruction for detecting the presence of an antibody against Babesia microti.

Assignments (4)
SECURITY INTEREST Recorded Jul 13, 2022
From: MEDICAL DIAGNOSTIC LABORATORIES, L.L.C.
To: TD BANK, N.A.
Reel/Frame 060638/0353 →
RELEASE OF SECURITY INTEREST Recorded Jun 12, 2018
From: WELLS FARGO BANK, NATIONAL ASSOCIATION
To: MEDICAL DIAGNOSTIC LABORATORIES L. L. C.
Reel/Frame 046354/0817 →
SECURITY INTEREST Recorded Apr 27, 2018
From: MEDICAL DIAGNOSTIC LABORATORIES, L.L.C.
To: TD BANK, N.A.
Reel/Frame 046031/0381 →
SECURITY INTEREST Recorded Mar 1, 2016
From: MEDICAL DIAGNOTIC LABORATORIES, L.L.C.
To: WELLS FARGO BANK, NATIONAL ASSOCIATION
Reel/Frame 037963/0744 →
Continuity (2)
Division 12386097 · Apr 14, 2009
Related Publication 20120202227A1 · Aug 9, 2012