IP Library › Granted Patent US 8,404,448
Granted Patent B2
US 8,404,448 · App. 13/355,234 · Granted Mar 26, 2013

DNA aptamer specifically binding to human cardiac troponin I

Inventors: Changill Ban (Pohang-si, KR); Kyung-Mi Song (Pohang-si, KR); Weejeong Jeon (Daejeon, KR)
Assignee: Postech Academy-Industry Foundation
View Patent ↗
Loading inventors, assignments & file history…
Monitor This Case
Get email alerts when status or documents change.
Order Certified Copies
Most orders are placed with the USPTO same day — all within 24 business hours.
Order via The Patent Place →
Pre-filled with this patent's details
Quick Facts
Patent No.
US 8,404,448
App. No.
13/355,234
Granted
Mar 26, 2013
Kind
B2
Abstract

Disclosed are a DNA aptamer specifically binding to human cardiac troponin I, and a composition and a diagnostic kit for the diagnosis of acute cardiovascular diseases, comprising the same. Being superior in specificity and stability to antibodies which are conventionally used to diagnose acute cardiovascular diseases, the DNA aptamers specifically binding to human cardiac troponin I can be developed into biosensors which determine human cardiac troponin I levels with high sensitivity and accuracy, greatly contributing to the diagnosis in an early stage of acute cardiovascular diseases. It is expected to lots of help for increase of diagnostic accuracy.

Claims (3)

1. A DNA aptamer specifically binding to human cardiac troponin I, wherein the DNA aptamer has a base sequence selected from the group consisting of SEQ ID NOS: 1 to 6.

2. A composition for diagnosis of an acute cardiovascular disease, comprising the DNA aptamer of claim 1 .

3. A diagnostic kit for an acute cardiovascular disease, comprising the DNA aptamer of claim 1 .

Assignments (4)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Nov 5, 2018
From: MD HEALTHCARE INC.
To: MD APTUS INC.
Reel/Frame 047415/0271 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded May 18, 2017
From: BAN, CHANGILL
To: MD HEALTHCARE INC.
Reel/Frame 042431/0445 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jul 27, 2016
From: POSTECH ACADEMY-INDUSTRY FOUNDATION
To: BAN, CHANGILL
Reel/Frame 039275/0207 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jan 20, 2012
From: BAN, CHANGILL; SONG, KYUNG-MI; JEON, WEEJEONG
To: POSTECH ACADEMY-INDUSTRY FOUNDATION
Reel/Frame 027571/0261 →
Priority Claims (2)
KR 10-2011-0054795 · Jun 7, 2011 · national
KR 10-2011-0145434 · Dec 29, 2011 · national
Continuity (1)
Related Publication 20120316326A1 · Dec 13, 2012